NKPD1_MOUSE
ID NKPD1_MOUSE Reviewed; 599 AA.
AC Q0VF94; Q9D7C6;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=NTPase KAP family P-loop domain-containing protein 1;
GN Name=Nkpd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VF94-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VF94-2; Sequence=VSP_026599;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26238.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK009357; BAB26238.1; ALT_INIT; mRNA.
DR EMBL; BC118925; AAI18926.1; -; mRNA.
DR RefSeq; NP_081392.1; NM_027116.1.
DR AlphaFoldDB; Q0VF94; -.
DR STRING; 10090.ENSMUSP00000077943; -.
DR PhosphoSitePlus; Q0VF94; -.
DR PaxDb; Q0VF94; -.
DR PRIDE; Q0VF94; -.
DR ProteomicsDB; 293568; -. [Q0VF94-1]
DR ProteomicsDB; 293569; -. [Q0VF94-2]
DR GeneID; 69547; -.
DR KEGG; mmu:69547; -.
DR CTD; 284353; -.
DR MGI; MGI:1916797; Nkpd1.
DR eggNOG; KOG0502; Eukaryota.
DR InParanoid; Q0VF94; -.
DR PhylomeDB; Q0VF94; -.
DR BioGRID-ORCS; 69547; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q0VF94; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q0VF94; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR011646; KAP_P-loop.
DR Pfam; PF07693; KAP_NTPase; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..599
FT /note="NTPase KAP family P-loop domain-containing protein
FT 1"
FT /id="PRO_0000294151"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..416
FT /note="KAP NTPase"
FT REGION 543..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..284
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026599"
SQ SEQUENCE 599 AA; 66831 MW; 54368EFC2571EBFB CRC64;
MQQEAAQRES EELQRVQWQP RRVRGWGVPK LLWFLVFLQP VITELHLRRR NVRFLFIRFS
AWQYAGTDKL WAGLVTTLCE GIRHHYGALP FSVYSVLGNK PCGPRDGLCQ REWHCRRRVC
LALLALLAAL CLGVGLLYLS LGGHAPGHGE RGVLKALGGA ATTLSGSGLL MAVYSVGKHL
FVSQRKKIER LVSREKFGSQ LGFMCEVKKE VELLTDFLCF LEIYQRRRLR VVLEVTGLDT
CYPERVVGVL NAINTLLSDS HAPFIFILVV DPSILAACLE SAGNMKGTAD NGYLFLNRTV
TLPFSVPIMG RRTKLQFLHD AVRSRDDLLF RELTIKLQPQ SPGNLGAGEG TQLLAVETQG
DAERTQGRVD AEAARRIQEA LCCLHDEGDC LYEYVPDNVV SMRRIVNTVP ITVRLLQQQQ
QQQPDRVGPT PRHAVAWVVL ANQWPCRLSW VLQCLEDRQQ AGGAPEGRSR LWDVFCDNSR
ELHTMTKALQ NVLDLDGDPE LFERFLGTDF PFTVAEAQSL LRCTVNLDHS IRRRMGLIRA
VSALKPPSPP KSPSQDGPQA SPRAIIAAGT SHAGQGSGHS KEAHQTRDRT HGGKPRPMA
