ID   NKX11_DANRE             Reviewed;         373 AA.
AC   Q75W95;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=NK1 transcription factor-related protein 1 {ECO:0000250|UniProtKB:Q15270};
DE   AltName: Full=Homeodomain protein Sax2 {ECO:0000303|PubMed:15183316};
DE   AltName: Full=NK1 transcription factor related 2-like,b;
GN   Name=nkx1.2lb {ECO:0000312|ZFIN:ZDB-GENE-040615-2};
GN   Synonyms=nkx1.1, sax2 {ECO:0000303|PubMed:15183316};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=15183316; DOI=10.1016/j.modgep.2003.12.001;
RA   Bae Y.K., Shimizu T., Muraoka O., Yabe T., Hirata T., Nojima H., Hirano T.,
RA   Hibi M.;
RT   "Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish.";
RL   Gene Expr. Patterns 4:481-486(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in the energy homeostasis regulation.
CC       {ECO:0000250|UniProtKB:G3UXB3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: First detected at the anterior position of the
CC       embryo at the first somite stage. From the late segmentation and
CC       pharyngula periods, expressed in a region ventral to the forebrain, and
CC       in the midbrain, hindbrain, and spinal cord. Expressed in the
CC       prospective extraocular muscles, mesencephalic neurons residing along
CC       the tract of the posterior commissure and interneurons in the spinal
CC       cord. {ECO:0000269|PubMed:15183316}.
CC   -!- SIMILARITY: Belongs to the NK-1 homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC129149; AAI29150.1; -; mRNA.
DR   EMBL; AB121758; BAD15087.1; -; mRNA.
DR   RefSeq; NP_998713.1; NM_213548.1.
DR   AlphaFoldDB; Q75W95; -.
DR   SMR; Q75W95; -.
DR   GeneID; 407077; -.
DR   KEGG; dre:407077; -.
DR   CTD; 407077; -.
DR   ZFIN; ZDB-GENE-040615-2; nkx1.2lb.
DR   InParanoid; Q75W95; -.
DR   OrthoDB; 1371237at2759; -.
DR   PhylomeDB; Q75W95; -.
DR   TreeFam; TF316128; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..373
FT                   /note="NK1 transcription factor-related protein 1"
FT                   /id="PRO_0000452745"
FT   DNA_BIND        227..286
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          49..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  40259 MW;  32FAF7743DED243F CRC64;
     MNREKVQVGD SVAPAGAGVI VVAPQDGMDD KRLAAGELPV FNCVGGRDAL PAESRETSPR
     HEPVPAGAPP TVHRTTSFSV LDILDPNKFT SKRQTPNRTG CEFAFGAENR SDDSNHTIEH
     KSYQEDYDCK KTSGILKDGF VFRSDECESD FTRGNQSDSE LQEDLCSEES SALTGNNDAE
     FGQHEDDDSI SKSPDGQQTQ QSSSNGQNHQ VKPKRKRSGS DSKSGKPRRA RTAFTYEQLV
     ALENKFKSTR YLSVCERLNL ALSLSLTETQ VKIWFQNRRT KWKKQNPGAD TSAPTSGGGG
     GNGPSNGLGG LSPLSPSPPM SGHLSMHTSY PGHTPGGLVC TTQLPFLPGH AVLSPFMLGS
     QTYGAPTFYA PHL