NKX11_HUMAN
ID NKX11_HUMAN Reviewed; 448 AA.
AC Q15270;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=NK1 transcription factor-related protein 1 {ECO:0000305};
DE AltName: Full=Homeobox protein 153;
DE Short=HPX-153 {ECO:0000303|PubMed:7518789};
DE AltName: Full=Homeobox protein SAX-2;
DE AltName: Full=NKX-1.1;
GN Name=NKX1-1 {ECO:0000312|HGNC:HGNC:24975};
GN Synonyms=HPX153 {ECO:0000303|PubMed:7518789}, SAX2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 304-342, AND TISSUE SPECIFICITY.
RC TISSUE=Bone marrow;
RX PubMed=7518789; DOI=10.1016/0378-1119(94)90380-8;
RA Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M.,
RA D'Andrea R.;
RT "Identification of homeobox genes expressed in human haemopoietic
RT progenitor cells.";
RL Gene 144:213-219(1994).
CC -!- FUNCTION: May be required for the coordinated crosstalk of factors
CC involved in the maintenance of energy homeostasis, possibly by
CC regulating the transcription of specific factors involved in energy
CC balance. {ECO:0000250|UniProtKB:G3UXB3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in hemopoietic progenitor cells.
CC {ECO:0000269|PubMed:7518789}.
CC -!- SIMILARITY: Belongs to the NK-1 homeobox family. {ECO:0000305}.
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DR EMBL; AC118281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X76978; CAA54282.1; -; mRNA.
DR PIR; I38143; I38143.
DR AlphaFoldDB; Q15270; -.
DR IntAct; Q15270; 1.
DR STRING; 9606.ENSP00000407978; -.
DR PhosphoSitePlus; Q15270; -.
DR BioMuta; NKX1-1; -.
DR DMDM; 189029591; -.
DR MassIVE; Q15270; -.
DR PaxDb; Q15270; -.
DR PeptideAtlas; Q15270; -.
DR PRIDE; Q15270; -.
DR ProteomicsDB; 60507; -.
DR Antibodypedia; 22251; 85 antibodies from 12 providers.
DR Ensembl; ENST00000422806.2; ENSP00000407978.2; ENSG00000235608.2.
DR MANE-Select; ENST00000422806.2; ENSP00000407978.2; NM_001290079.1; NP_001277008.1.
DR UCSC; uc062ulo.1; human.
DR GeneCards; NKX1-1; -.
DR HGNC; HGNC:24975; NKX1-1.
DR HPA; ENSG00000235608; Not detected.
DR MIM; 617869; gene.
DR neXtProt; NX_Q15270; -.
DR PharmGKB; PA145148380; -.
DR VEuPathDB; HostDB:ENSG00000235608; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000162861; -.
DR HOGENOM; CLU_063378_1_0_1; -.
DR InParanoid; Q15270; -.
DR PhylomeDB; Q15270; -.
DR TreeFam; TF316128; -.
DR PathwayCommons; Q15270; -.
DR SignaLink; Q15270; -.
DR Pharos; Q15270; Tdark.
DR PRO; PR:Q15270; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q15270; protein.
DR Bgee; ENSG00000235608; Expressed in left testis and 2 other tissues.
DR Genevisible; Q15270; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR GO; GO:0050877; P:nervous system process; IEA:Ensembl.
DR GO; GO:0043467; P:regulation of generation of precursor metabolites and energy; IEA:Ensembl.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..448
FT /note="NK1 transcription factor-related protein 1"
FT /id="PRO_0000333009"
FT DNA_BIND 296..355
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..205
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 331
FT /note="L -> V (in Ref. 2; CAA54282)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 448 AA; 44012 MW; 1DA2864CAF0746AC CRC64;
MSASGPEAPG DIPALPPPPQ PGSGPAPPAP AAAAQEAMDG RAELPAFPRA GAPPLAASDT
VPAAPEGAGA ARPAAPLRPT SFSVLDILDP NKFNSRRRRC VLLGPVAPAA CAPCASAPCA
PAPAASGRPP RAEELERRAL AGAGGVGAAG AEPPNAGDPF KAGEAETNDT NGYSSGGGGH
SPSADSGDEV PDDEDDDEDE APETEAARGA EEARGGGGGL GARGSGCQGA AETDASPGAT
VDEAAAPGPR ENSPVAQGPP GGAAAPGGAG TTPQGTATAA KPKRKRTGSD SKSGKPRRAR
TAFTYEQLVA LENKFKATRY LSVCERLNLA LSLSLTETQV KIWFQNRRTK WKKQNPGADT
SAPTGGGGGP GPGAGPGTGL PGGLSPLSPS PPMGAPLGMH GPAGYPAHGP GGLVCAAQLP
FLSSPAVLSP FVLGSQTYGA PAFYAPHL
