ID   NKX22_MESAU             Reviewed;         273 AA.
AC   P43697;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Homeobox protein Nkx-2.2;
DE   AltName: Full=Homeobox protein NK-2 homolog B;
GN   Name=NKX2-2; Synonyms=NKX-2.2, NKX2B;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreatic islet;
RX   PubMed=7991607; DOI=10.1073/pnas.91.25.12203;
RA   Rudnick A., Ling T.Y., Odagiri H., Rutter W.J., German M.S.;
RT   "Pancreatic beta cells express a diverse set of homeobox genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:12203-12207(1994).
CC   -!- FUNCTION: Transcriptional activator involved in the development of
CC       insulin-producting beta cells in the endocrine pancreas (By
CC       similarity). May also be involved in specifying diencephalic neuromeric
CC       boundaries, and in controlling the expression of genes that play a role
CC       in axonal guidance. Binds to elements within the NEUROD1 promoter (By
CC       similarity). {ECO:0000250|UniProtKB:P42586}.
CC   -!- SUBUNIT: Interacts with OLIG2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P42586,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DOMAIN: The homeodomain is essential for interaction with OLIG2.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X81408; CAA57165.1; -; mRNA.
DR   PIR; I48187; I48187.
DR   RefSeq; NP_001297481.1; NM_001310552.1.
DR   AlphaFoldDB; P43697; -.
DR   SMR; P43697; -.
DR   STRING; 10036.XP_005072621.1; -.
DR   GeneID; 101837061; -.
DR   CTD; 4821; -.
DR   eggNOG; KOG0842; Eukaryota.
DR   OrthoDB; 1072653at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..273
FT                   /note="Homeobox protein Nkx-2.2"
FT                   /id="PRO_0000048930"
FT   DNA_BIND        128..187
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..35
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   273 AA;  30065 MW;  3269F6F699E922A2 CRC64;
     MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEESEGPE PAKRAGPLGQ GALDAVHSLP
     LKSPFYDSSD NPYTRWLAST EGLQYSLHGL AASAPPQDSS SKSPEPSADE SPDNDKETPG
     GGGDAGKKRK RRVLFSKAQT YELERRFRQQ RYLSAPEREH LASLIRLTPT QVKIWFQNHR
     YKMKRARAEK GMEVTPLPSP RCVAVPVLVR DGKPCHALKA QDLAAATFQA GIPFSAYSAQ
     SLQHMQYNAQ YSSASTPQYP TAHPLVQAQQ WTW