NKX24_MOUSE
ID NKX24_MOUSE Reviewed; 354 AA.
AC Q9EQM3; A2ATK2; Q9EQM4;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Homeobox protein Nkx-2.4;
DE AltName: Full=Homeobox protein NK-2 homolog D;
GN Name=Nkx2-4; Synonyms=Nkx2d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129/Sv, and C57BL/6J;
RX PubMed=10818213; DOI=10.1007/s003350010089;
RA Wang C.-C., Brodnicki T., Copeland N.G., Jenkins N.A., Harvey R.P.;
RT "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in
RT mammals.";
RL Mamm. Genome 11:466-468(2000).
RN [2]
RP PARTIAL NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J;
RX PubMed=1346742; DOI=10.1016/0896-6273(92)90291-k;
RA Price M., Lazzaro D., Pohl T., Mattei M.-G., Ruether U., Olivo J.-C.,
RA Duboule D., di Lauro R.;
RT "Regional expression of the homeobox gene Nkx-2.2 in the developing
RT mammalian forebrain.";
RL Neuron 8:241-255(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Probable transcription factor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: In the embryo it is detected in the posterior
CC hypotalamus and later in the head. In the adult it is detected only in
CC testis.
CC -!- DEVELOPMENTAL STAGE: Expressed in a restricted region of the posterior
CC hypothalamus from 10 dpc. Detected in the head region from 12.5 dpc to
CC 14.5 dpc. Expression is down-regulated by 15.5 dpc.
CC -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR EMBL; AF202038; AAG35618.1; -; Genomic_DNA.
DR EMBL; AF202039; AAG35619.1; -; mRNA.
DR EMBL; AL928876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16833.1; -.
DR RefSeq; NP_075993.1; NM_023504.1.
DR AlphaFoldDB; Q9EQM3; -.
DR SMR; Q9EQM3; -.
DR STRING; 10090.ENSMUSP00000066690; -.
DR PhosphoSitePlus; Q9EQM3; -.
DR MaxQB; Q9EQM3; -.
DR PaxDb; Q9EQM3; -.
DR PRIDE; Q9EQM3; -.
DR Antibodypedia; 60221; 150 antibodies from 24 providers.
DR DNASU; 228731; -.
DR Ensembl; ENSMUST00000067020; ENSMUSP00000066690; ENSMUSG00000054160.
DR GeneID; 228731; -.
DR KEGG; mmu:228731; -.
DR UCSC; uc008mss.1; mouse.
DR CTD; 644524; -.
DR MGI; MGI:97349; Nkx2-4.
DR VEuPathDB; HostDB:ENSMUSG00000054160; -.
DR eggNOG; KOG0842; Eukaryota.
DR GeneTree; ENSGT00940000162247; -.
DR HOGENOM; CLU_052416_0_0_1; -.
DR InParanoid; Q9EQM3; -.
DR OMA; SLCQQQA; -.
DR OrthoDB; 1348801at2759; -.
DR PhylomeDB; Q9EQM3; -.
DR TreeFam; TF351204; -.
DR BioGRID-ORCS; 228731; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q9EQM3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9EQM3; protein.
DR Bgee; ENSMUSG00000054160; Expressed in urethra and 61 other tissues.
DR Genevisible; Q9EQM3; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..354
FT /note="Homeobox protein Nkx-2.4"
FT /id="PRO_0000048936"
FT DNA_BIND 188..247
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 245..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 36225 MW; A7A0F450DB15616C CRC64;
MSLSPKHTTP FSVSDILSPI EETYKKFGGV MDGAPPGLGA PLGAAAYRAP PSGPSSQAAA
VAAGMQPPHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS QFPHSAMGSY CNGGLGNMGE
LPAYTDGMRG GAAAAATGWY GANTDPRYSS ISRFMGPSAG VNVAGMGSLT GIADAAKSLA
PLHAAAPRRK RRVLFSQAQV YELERRFKQQ KYLSAPEREH LASMIHLTPT QVKIWFQNHR
YKMKRQAKDK AAQQLQQEGG LGPPPPPPPP SPRRVAVPVL VKDGKPCQNG AGTPTPGQGG
QQPQAPTPAP ELEELSPSPP ALHGPGGGLA ALDAATGDYG GGVLGANLLY GRTW
