NKX25_CHICK
ID NKX25_CHICK Reviewed; 294 AA.
AC Q90788;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Homeobox protein Nkx-2.5;
DE Short=cNKx-2.5;
DE AltName: Full=Homeobox protein NK-2 homolog E;
GN Name=NKX-2.5; Synonyms=NKX2E;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8575320; DOI=10.1242/dev.121.12.4203;
RA Schultheiss T.M., Xydas S., Lassar A.B.;
RT "Induction of avian cardiac myogenesis by anterior endoderm.";
RL Development 121:4203-4214(1995).
CC -!- FUNCTION: Transcription factor required for the development of the
CC heart and the spleen. Implicated in commitment to and/or
CC differentiation of the myocardial lineage. Binds to the core DNA motif
CC of promoter. {ECO:0000250|UniProtKB:P42582,
CC ECO:0000250|UniProtKB:P52952}.
CC -!- SUBUNIT: Homodimer (via the homeobox); binds DNA as homodimer.
CC {ECO:0000250|UniProtKB:P52952}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P42582}.
CC -!- DOMAIN: The homeobox domain binds to double-stranded DNA.
CC {ECO:0000250|UniProtKB:P52952}.
CC -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR EMBL; X91838; CAA62955.1; -; mRNA.
DR RefSeq; NP_990495.1; NM_205164.1.
DR AlphaFoldDB; Q90788; -.
DR SMR; Q90788; -.
DR STRING; 9031.ENSGALP00000004542; -.
DR PaxDb; Q90788; -.
DR GeneID; 396073; -.
DR KEGG; gga:396073; -.
DR CTD; 1482; -.
DR VEuPathDB; HostDB:geneid_396073; -.
DR eggNOG; KOG0842; Eukaryota.
DR InParanoid; Q90788; -.
DR OrthoDB; 1191455at2759; -.
DR PhylomeDB; Q90788; -.
DR PRO; PR:Q90788; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0032993; C:protein-DNA complex; ISS:UniProtKB.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0007512; P:adult heart development; IEA:Ensembl.
DR GO; GO:0003278; P:apoptotic process involved in heart morphogenesis; IEA:Ensembl.
DR GO; GO:0003228; P:atrial cardiac muscle tissue development; IEA:Ensembl.
DR GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl.
DR GO; GO:0060928; P:atrioventricular node cell development; IEA:Ensembl.
DR GO; GO:0060929; P:atrioventricular node cell fate commitment; IEA:Ensembl.
DR GO; GO:0003166; P:bundle of His development; IEA:Ensembl.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
DR GO; GO:0003211; P:cardiac ventricle formation; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0060971; P:embryonic heart tube left/right pattern formation; IEA:Ensembl.
DR GO; GO:1904019; P:epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0060347; P:heart trabecula formation; IEA:Ensembl.
DR GO; GO:0030097; P:hemopoiesis; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Ensembl.
DR GO; GO:1904036; P:negative regulation of epithelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0051891; P:positive regulation of cardioblast differentiation; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045823; P:positive regulation of heart contraction; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:Ensembl.
DR GO; GO:0010735; P:positive regulation of transcription via serum response element binding; IEA:Ensembl.
DR GO; GO:0003342; P:proepicardium development; IEA:Ensembl.
DR GO; GO:0003350; P:pulmonary myocardium development; IEA:Ensembl.
DR GO; GO:0003168; P:Purkinje myocyte differentiation; IEA:Ensembl.
DR GO; GO:1903779; P:regulation of cardiac conduction; IEA:Ensembl.
DR GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0071772; P:response to BMP; IDA:AgBase.
DR GO; GO:0003221; P:right ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR GO; GO:0003285; P:septum secundum development; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR GO; GO:0055005; P:ventricular cardiac myofibril assembly; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR033629; NKX-2.5.
DR PANTHER; PTHR24340:SF28; PTHR24340:SF28; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..294
FT /note="Homeobox protein Nkx-2.5"
FT /id="PRO_0000048940"
FT DNA_BIND 119..178
FT /note="Homeobox"
FT /evidence="ECO:0000250|UniProtKB:P52952,
FT ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 48..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..69
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 294 AA; 33073 MW; E963373B2C074A32 CRC64;
MFPSPVTTTP FSVKDILNLE QQQQGGLAPM ELSSPSCMLA TFKQEAFGSE PPALPELPEP
PPAKPPAAFP GPYYVKSYGE MDTAKDSKAD KKELCALHKS LEQEKRELED PERPRQRKRR
KPRVLFSQAQ VYELERRFKQ QKYLSAPERD HLANVLKLTS TQVKIWFQNR RYKCKRQRQD
QTLEMVGIPP PRRIAVPVLV RDGKPCLGES SPYSSPYNVS INPYSYNAYP AYPNYNSPAC
NANYNCSYPA VQPVQPSAAG NNFMNFSVGD LNSVQPPIPQ GNAGISTLHG IRAW
