NKX28_MOUSE
ID NKX28_MOUSE Reviewed; 235 AA.
AC O70584; B2RWY9;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Homeobox protein Nkx-2.8;
DE AltName: Full=Homeobox protein NK-2 homolog H;
DE AltName: Full=Homeobox protein Nkx-2.9;
GN Name=Nkx2-8; Synonyms=Nkx-2.9, Nkx2-9, Nkx2h;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129;
RX PubMed=9545546; DOI=10.1016/s0925-4773(98)00035-5;
RA Pabst O., Herbrand H., Arnold H.H.;
RT "Nkx2-9 is a novel homeobox transcription factor which demarcates ventral
RT domains in the developing mouse CNS.";
RL Mech. Dev. 73:85-93(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible role in the specification of a distinct subset of
CC neurons.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Prominent expression in ventral brain and neural
CC tube structures.
CC -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR EMBL; Y15741; CAA75751.1; -; mRNA.
DR EMBL; AC160393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466526; EDL36709.1; -; Genomic_DNA.
DR EMBL; BC150762; AAI50763.1; -; mRNA.
DR CCDS; CCDS25923.1; -.
DR RefSeq; NP_032727.2; NM_008701.2.
DR RefSeq; XP_006515596.1; XM_006515533.3.
DR AlphaFoldDB; O70584; -.
DR SMR; O70584; -.
DR STRING; 10090.ENSMUSP00000072425; -.
DR MaxQB; O70584; -.
DR PaxDb; O70584; -.
DR PRIDE; O70584; -.
DR ProteomicsDB; 293669; -.
DR Antibodypedia; 9891; 199 antibodies from 28 providers.
DR DNASU; 18094; -.
DR Ensembl; ENSMUST00000072631; ENSMUSP00000072425; ENSMUSG00000058669.
DR GeneID; 18094; -.
DR KEGG; mmu:18094; -.
DR UCSC; uc007nph.1; mouse.
DR CTD; 18094; -.
DR MGI; MGI:1270158; Nkx2-9.
DR VEuPathDB; HostDB:ENSMUSG00000058669; -.
DR eggNOG; KOG0842; Eukaryota.
DR GeneTree; ENSGT00940000161610; -.
DR HOGENOM; CLU_049543_0_3_1; -.
DR InParanoid; O70584; -.
DR OMA; AYQHLAH; -.
DR OrthoDB; 1596695at2759; -.
DR PhylomeDB; O70584; -.
DR TreeFam; TF351204; -.
DR BioGRID-ORCS; 18094; 3 hits in 71 CRISPR screens.
DR PRO; PR:O70584; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; O70584; protein.
DR Bgee; ENSMUSG00000058669; Expressed in morula and 30 other tissues.
DR Genevisible; O70584; MM.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007409; P:axonogenesis; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0050673; P:epithelial cell proliferation; IMP:MGI.
DR GO; GO:0030324; P:lung development; IMP:MGI.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030323; P:respiratory tube development; IMP:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006351; P:transcription, DNA-templated; ISO:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..235
FT /note="Homeobox protein Nkx-2.8"
FT /id="PRO_0000048944"
FT DNA_BIND 81..140
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 51..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 167
FT /note="V -> M (in Ref. 1; CAA75751)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="D -> E (in Ref. 1; CAA75751)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="Y -> N (in Ref. 1; CAA75751)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="P -> T (in Ref. 1; CAA75751)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 26133 MW; 71ED9B0EA0F204C1 CRC64;
MATSGRLGFT VRSLLNLPEQ DAKPRVRREQ QTCVPQTAAW LESECSHYLS SDESGLETSP
ADSSQLASLR RESPGSDPEK RRKRRVLFSK AQTLELERRF RQQRYLSAPE REQLARLLRL
TPTQVKIWFQ NHRYKLKRGR APGITEPSDM AASSDLHAAP GLLRRVVVPV LVHDRPPSNN
GRGEGTSAVP QDKCSARLAT ACPVPGYTAF GPGSALGLFP AYQHLAPPAL VSWNW
