ID   NKX32_XENLA             Reviewed;         329 AA.
AC   P70061;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Homeobox protein Nkx-3.2;
DE   AltName: Full=Bagpipe homeobox protein homolog 1;
DE   AltName: Full=Xbap;
GN   Name=nkx3-2; Synonyms=bap {ECO:0000303|PubMed:15229177}, bapx1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAB82336.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryonic head {ECO:0000269|PubMed:9013932};
RX   PubMed=9013932; DOI=10.1006/dbio.1996.8416;
RA   Newman C.S., Grow M.W., Cleaver O., Chia F., Krieg P.;
RT   "Xbap, a vertebrate gene related to bagpipe, is expressed in developing
RT   craniofacial structures and in anterior gut muscle.";
RL   Dev. Biol. 181:223-233(1997).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=15229177; DOI=10.1242/dev.01234;
RA   Tseng H.-T., Shah R., Jamrich M.;
RT   "Function and regulation of FoxF1 during Xenopus gut development.";
RL   Development 131:3637-3647(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: First expressed in developing facial cartilage in
CC       early tailbud embryos, with expression localized to the
CC       basihyobranchial, palatoquadrate and possibly Meckel's cartilages.
CC       Shortly after, a second area of expression is seen in the musculature
CC       of the anterior gut. During late embryogenesis, gut expression extends
CC       into hindgut tissues. In adults, expressed at a high level in the
CC       kidney, pancreas, spleen and stomach and at a slightly lower level in
CC       the intestine, skeletal muscle and tongue. Adult heart, liver and lung
CC       show little or no expression. {ECO:0000269|PubMed:15229177,
CC       ECO:0000269|PubMed:9013932}.
CC   -!- DEVELOPMENTAL STAGE: First expressed during late neurula stage (stage
CC       18). Levels increase slowly up to the tailbud stage (stage 28), then
CC       increase sharply before remaining approximately constant through the
CC       remaining tailbud and tadpole stages (stages 30-44).
CC       {ECO:0000269|PubMed:9013932}.
CC   -!- INDUCTION: By foxf1-B. {ECO:0000269|PubMed:15229177}.
CC   -!- SIMILARITY: Belongs to the NK-3 homeobox family. {ECO:0000255}.
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DR   EMBL; U75487; AAB82336.1; -; mRNA.
DR   RefSeq; NP_001079282.1; NM_001085813.1.
DR   AlphaFoldDB; P70061; -.
DR   SMR; P70061; -.
DR   GeneID; 378569; -.
DR   KEGG; xla:378569; -.
DR   CTD; 378569; -.
DR   Xenbase; XB-GENE-876836; nkx3-2.S.
DR   OMA; CEIGASV; -.
DR   OrthoDB; 1303626at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 378569; Expressed in stomach and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..329
FT                   /note="Homeobox protein Nkx-3.2"
FT                   /id="PRO_0000271891"
FT   DNA_BIND        202..261
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          107..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  36000 MW;  8F53AE997C91EE47 CRC64;
     MFRGPLDTPW AADVSPSGPR GIKAGRSALL VPILGSIWGA WRPEPGATRY RTLDPMAAVR
     SSSRLTPFSI QAILNRKEER AHTFPRLATA VSPACCWRIF GESEAEGLGS PCGGAPGAGA
     GGEPSGWDSD SALSEEGELG RPGDIGERKK QRPLEARAKG EDEEETPGCS DCEIGASVPD
     PSPPDEDPKC EQLMLEPPKQ RKKRSRAAFS HAQVFELERR FNHQRYLSGP ERADLAASLK
     LTETQVKIWF QNRRYKTKRR QMATDLLAAA PAAKKVAVKV LVRDDQRQYH PGEVLHPSLL
     PLQAPYFYPY YCALPGWTLS AAACSRGTP