ID   NKX63_XENLA             Reviewed;         254 AA.
AC   A5YC49;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Homeobox protein Nkx-6.3;
GN   Name=nkx6-3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=17450377; DOI=10.1007/s00427-007-0155-2;
RA   Zhao S., Jiang H., Wang W., Mao B.;
RT   "Cloning and developmental expression of the Xenopus Nkx6 genes.";
RL   Dev. Genes Evol. 217:477-483(2007).
CC   -!- FUNCTION: Putative transcription factor, which may be involved in
CC       patterning of central nervous system and pancreas. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Detected in the non-neural ectoderm from cleavage
CC       to early neurula stages and in the caudal hindbrain and the mandibular
CC       arch at tail bud stages. {ECO:0000269|PubMed:17450377}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF460790; ABQ86051.1; -; mRNA.
DR   RefSeq; NP_001093371.1; NM_001099901.1.
DR   AlphaFoldDB; A5YC49; -.
DR   SMR; A5YC49; -.
DR   GeneID; 100101319; -.
DR   KEGG; xla:100101319; -.
DR   CTD; 100101319; -.
DR   Xenbase; XB-GENE-865197; nkx6-3.L.
DR   OrthoDB; 1263401at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 100101319; Expressed in intestine and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Homeobox protein Nkx-6.3"
FT                   /id="PRO_0000311332"
FT   DNA_BIND        133..192
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          112..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..228
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   254 AA;  27898 MW;  DF8E264F28DCE764 CRC64;
     METHHPGAFL LPSYSEMKSS GCQFPTHTPF HKLNPSVLGC HLPSGTPHCI SDILSRPLPA
     SHSGMFPGYP TVQGYGSSSV PGTCYGEQGN ILTKSGTPYT NQSQGGWTDI EQDWRGGNPA
     LSSASNTEGS SRKKHTRPTF TGHQIFALEK TFEQTKYLAG PERARLAFSL GMSESQVKVW
     FQNRRTKWRK KSAVETPGLP SLSTRAPGDL IPSDNEDDEY SKPLDPDSDD EKIRLLLRKH
     RAAFSVLSLA SHNL