ID   NLE1_PONAB              Reviewed;         485 AA.
AC   Q5RFF8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 3.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Notchless protein homolog 1;
GN   Name=NLE1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in regulating Notch activity. Plays a role in
CC       regulating the expression of CDKN1A and several members of the Wnt
CC       pathway, probably via its effects on Notch activity. Required during
CC       embryogenesis for inner mass cell survival (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the pre-60S ribosomal particle. Interacts (via
CC       WD repeats) with uL18 (By similarity). Interacts (via UBL domain) with
CC       MDN1 (via VWFA/MIDAS domain) (By similarity).
CC       {ECO:0000250|UniProtKB:P25382, ECO:0000250|UniProtKB:Q9NVX2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NLE1/RSA4 family. {ECO:0000305}.
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DR   EMBL; CR857200; CAH89499.1; -; mRNA.
DR   RefSeq; NP_001124648.1; NM_001131176.1.
DR   AlphaFoldDB; Q5RFF8; -.
DR   SMR; Q5RFF8; -.
DR   GeneID; 100171489; -.
DR   KEGG; pon:100171489; -.
DR   CTD; 54475; -.
DR   eggNOG; KOG0271; Eukaryota.
DR   InParanoid; Q5RFF8; -.
DR   OrthoDB; 723347at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001632; Gprotein_B.
DR   InterPro; IPR012972; NLE.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF08154; NLE; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00319; GPROTEINB.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Notch signaling pathway; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVX2"
FT   CHAIN           2..485
FT                   /note="Notchless protein homolog 1"
FT                   /id="PRO_0000051100"
FT   REPEAT          112..151
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          154..193
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          197..241
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          244..282
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          325..366
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          370..409
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          412..451
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          454..485
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REGION          14..96
FT                   /note="Ubiquitin-like (UBL) domain"
FT                   /evidence="ECO:0000250|UniProtKB:P25382"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVX2"
FT   MOD_RES         79
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVX2"
SQ   SEQUENCE   485 AA;  53312 MW;  7171CF03456DD1CF CRC64;
     MAAAVADEAV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL
     AFFVHDAEII SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV
     AFSPTGKYLA SGSGDTTVRF WDLSTETPHF TCKGHRHWVL SISWSPDGKK LASGCKNGQI
     LLWDPSTGKQ VGRTLAGHSK WITGLSWEPL HANPECRYVA SSSKDGSVRI WDTTAGRCER
     ILTGHTQSVT CLRWGGDGLL YSASQDRTIK VWRAHDGVLC RTLQGHGHWV NTMALSTDYA
     LRTGAFEPAE ASVNPQDLQG SLQELKERAL SRYNLMRGQG PERLVSGSDD FTLFLWSPAE
     DKKPLTRMTG HQALINQVLF SPDSRIVASA SFDKSIKLWD GRTGKYLASL RGHVAAVYQI
     AWSADSRLLV SGSSDSTLKV WDVKAQKLAM DLPGHADEVY AVDWSPDGQR VASGGKDKCL
     RIWRR