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NLGN3_HUMAN
ID   NLGN3_HUMAN             Reviewed;         848 AA.
AC   Q9NZ94; B2RBK1; D2X2H6; D3DVV0; D3DVV1; Q86V51; Q8NCD0; Q9NZ95; Q9NZ96;
AC   Q9NZ97; Q9P248;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2003, sequence version 2.
DT   03-AUG-2022, entry version 188.
DE   RecName: Full=Neuroligin-3;
DE   AltName: Full=Gliotactin homolog;
DE   Flags: Precursor;
GN   Name=NLGN3; Synonyms=KIAA1480, NL3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), AND TISSUE
RP   SPECIFICITY.
RX   PubMed=10767552; DOI=10.1016/s0378-1119(00)00049-4;
RA   Philibert R.A., Winfield S.L., Sandhu H.K., Martin B.M., Ginns E.I.;
RT   "The structure and expression of the human neuroligin-3 gene.";
RL   Gene 246:303-310(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=20034102; DOI=10.1002/dvdy.22196;
RA   Rissone A., Sangiorgio L., Monopoli M., Beltrame M., Zucchi I.,
RA   Bussolino F., Arese M., Cotelli F.;
RT   "Characterization of the neuroligin gene family expression and evolution in
RT   zebrafish.";
RL   Dev. Dyn. 239:688-702(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 410-848 (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS TYR-92;
RP   ILE-718; TRP-751 AND SER-778.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-848.
RC   TISSUE=Brain;
RX   PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:143-150(2000).
RN   [8]
RP   INTERACTION WITH DLG4.
RX   PubMed=9278515; DOI=10.1126/science.277.5331.1511;
RA   Irie M., Hata Y., Takeuchi M., Ichtchenko K., Toyoda A., Hirao K.,
RA   Takai Y., Rosahl T.W., Suedhof T.C.;
RT   "Binding of neuroligins to PSD-95.";
RL   Science 277:1511-1515(1997).
RN   [9]
RP   FUNCTION.
RX   PubMed=15620359; DOI=10.1016/j.cell.2004.11.035;
RA   Graf E.R., Zhang X., Jin S.X., Linhoff M.W., Craig A.M.;
RT   "Neurexins induce differentiation of GABA and glutamate postsynaptic
RT   specializations via neuroligins.";
RL   Cell 119:1013-1026(2004).
RN   [10]
RP   TISSUE SPECIFICITY, AND ALTERNATIVE SPLICING.
RX   PubMed=18755801; DOI=10.1210/en.2008-0274;
RA   Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S.,
RA   Taylor P., Chessler S.D.;
RT   "Expression of neurexin, neuroligin, and their cytoplasmic binding partners
RT   in the pancreatic beta-cells and the involvement of neuroligin in insulin
RT   secretion.";
RL   Endocrinology 149:6006-6017(2008).
RN   [11]
RP   TISSUE SPECIFICITY.
RX   PubMed=19926856; DOI=10.1073/pnas.0809510106;
RA   Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B.,
RA   Cera M.R., Mascia L., Bussolino F., Arese M.;
RT   "The synaptic proteins neurexins and neuroligins are widely expressed in
RT   the vascular system and contribute to its functions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009).
RN   [12]
RP   VARIANT AUTSX1 CYS-451, AND VARIANT ASPGX1 CYS-451.
RX   PubMed=12669065; DOI=10.1038/ng1136;
RA   Jamain S., Quach H., Betancur C., Rastam M., Colineaux C., Gillberg I.C.,
RA   Soderstrom H., Giros B., Leboyer M., Gillberg C., Bourgeron T., Nyden A.,
RA   Philippe A., Cohen D., Chabane N., Mouren-Simeoni M.C., Brice A.,
RA   Sponheim E., Spurkland I., Skjeldal O.H., Coleman M., Pearl P.L.,
RA   Cohen I.L., Tsiouris J., Zappella M., Menchetti G., Pompella A.,
RA   Aschauer H., Van Maldergem L.;
RT   "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are
RT   associated with autism.";
RL   Nat. Genet. 34:27-29(2003).
CC   -!- FUNCTION: Cell surface protein involved in cell-cell-interactions via
CC       its interactions with neurexin family members. Plays a role in synapse
CC       function and synaptic signal transmission, and may mediate its effects
CC       by clustering other synaptic proteins. May promote the initial
CC       formation of synapses, but is not essential for this. May also play a
CC       role in glia-glia or glia-neuron interactions in the developing
CC       peripheral nervous system (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:15620359}.
CC   -!- SUBUNIT: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-
CC       terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity).
CC       Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9NZ94-2; P49753: ACOT2; NbExp=2; IntAct=EBI-16423037, EBI-1052865;
CC       Q9NZ94-2; P05108: CYP11A1; NbExp=3; IntAct=EBI-16423037, EBI-7183136;
CC       Q9NZ94-2; P68104: EEF1A1; NbExp=4; IntAct=EBI-16423037, EBI-352162;
CC       Q9NZ94-2; Q8IWB1: ITPRIP; NbExp=5; IntAct=EBI-16423037, EBI-2556412;
CC       Q9NZ94-2; P00403: MT-CO2; NbExp=4; IntAct=EBI-16423037, EBI-2105756;
CC       Q9NZ94-2; Q15274: QPRT; NbExp=4; IntAct=EBI-16423037, EBI-739851;
CC       Q9NZ94-2; Q86W33: TPRA1; NbExp=3; IntAct=EBI-16423037, EBI-16424742;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Detected at
CC       both glutamatergic and GABAergic synapses. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=HNL3s;
CC         IsoId=Q9NZ94-1; Sequence=Displayed;
CC       Name=2; Synonyms=HNL3;
CC         IsoId=Q9NZ94-2; Sequence=VSP_007534;
CC       Name=3;
CC         IsoId=Q9NZ94-3; Sequence=VSP_053827;
CC   -!- TISSUE SPECIFICITY: Expressed in the blood vessel walls (at protein
CC       level). Detected in throughout the brain and in spinal cord. Detected
CC       in brain, and at lower levels in pancreas islet beta cells.
CC       {ECO:0000269|PubMed:10767552, ECO:0000269|PubMed:18755801,
CC       ECO:0000269|PubMed:19926856}.
CC   -!- DISEASE: Autism, X-linked 1 (AUTSX1) [MIM:300425]: A complex
CC       multifactorial, pervasive developmental disorder characterized by
CC       impairments in reciprocal social interaction and communication,
CC       restricted and stereotyped patterns of interests and activities, and
CC       the presence of developmental abnormalities by 3 years of age. Most
CC       individuals with autism also manifest moderate intellectual disability.
CC       {ECO:0000269|PubMed:12669065}. Note=Disease susceptibility is
CC       associated with variants affecting the gene represented in this entry.
CC   -!- DISEASE: Asperger syndrome, X-linked, 1 (ASPGX1) [MIM:300494]: A
CC       syndrome with features similar to autism. Affected individuals exhibit
CC       qualitative impairment in social interaction, as manifest by impairment
CC       in the use of non-verbal behaviors such as eye-to-eye gaze, facial
CC       expression, body postures, and gestures, failure to develop appropriate
CC       peer relationships, and lack of social sharing or reciprocity. Patients
CC       also exhibit restricted, repetitive and stereotyped patterns of
CC       behavior, interests, and activities, including abnormal preoccupation
CC       with certain activities and inflexible adherence to routines or
CC       rituals. Asperger syndrome is primarily distinguished from autism by
CC       the higher cognitive abilities and a more normal and timely development
CC       of language and communicative phrases. {ECO:0000269|PubMed:12669065}.
CC       Note=Disease susceptibility is associated with variants affecting the
CC       gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF71231.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC       Sequence=BAA96004.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC11226.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF217411; AAF71230.1; -; mRNA.
DR   EMBL; AF217412; AAF71231.1; ALT_SEQ; mRNA.
DR   EMBL; AF217413; AAF71232.1; -; Genomic_DNA.
DR   EMBL; AF217413; AAF71233.1; -; Genomic_DNA.
DR   EMBL; GQ489207; ADB12634.1; -; mRNA.
DR   EMBL; AK074814; BAC11226.1; ALT_INIT; mRNA.
DR   EMBL; AK314699; BAG37248.1; -; mRNA.
DR   EMBL; AL590764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471132; EAX05307.1; -; Genomic_DNA.
DR   EMBL; CH471132; EAX05308.1; -; Genomic_DNA.
DR   EMBL; CH471132; EAX05309.1; -; Genomic_DNA.
DR   EMBL; CH471132; EAX05310.1; -; Genomic_DNA.
DR   EMBL; CH471132; EAX05312.1; -; Genomic_DNA.
DR   EMBL; CH471132; EAX05313.1; -; Genomic_DNA.
DR   EMBL; BC051715; AAH51715.1; -; mRNA.
DR   EMBL; AB040913; BAA96004.1; ALT_INIT; mRNA.
DR   CCDS; CCDS14407.1; -. [Q9NZ94-2]
DR   CCDS; CCDS55441.1; -. [Q9NZ94-1]
DR   CCDS; CCDS55442.1; -. [Q9NZ94-3]
DR   RefSeq; NP_001160132.1; NM_001166660.1. [Q9NZ94-3]
DR   RefSeq; NP_001308205.1; NM_001321276.1.
DR   RefSeq; NP_061850.2; NM_018977.3. [Q9NZ94-2]
DR   RefSeq; NP_851820.1; NM_181303.1. [Q9NZ94-1]
DR   AlphaFoldDB; Q9NZ94; -.
DR   BMRB; Q9NZ94; -.
DR   SMR; Q9NZ94; -.
DR   BioGRID; 119944; 93.
DR   IntAct; Q9NZ94; 81.
DR   MINT; Q9NZ94; -.
DR   STRING; 9606.ENSP00000351591; -.
DR   ESTHER; human-NLGN3; Neuroligin.
DR   MEROPS; S09.987; -.
DR   TCDB; 8.A.117.1.6; the neuroligin (nlg) family.
DR   GlyGen; Q9NZ94; 2 sites.
DR   iPTMnet; Q9NZ94; -.
DR   PhosphoSitePlus; Q9NZ94; -.
DR   BioMuta; NLGN3; -.
DR   DMDM; 31076855; -.
DR   EPD; Q9NZ94; -.
DR   jPOST; Q9NZ94; -.
DR   MassIVE; Q9NZ94; -.
DR   PaxDb; Q9NZ94; -.
DR   PeptideAtlas; Q9NZ94; -.
DR   PRIDE; Q9NZ94; -.
DR   ProteomicsDB; 12770; -.
DR   ProteomicsDB; 83341; -. [Q9NZ94-1]
DR   ProteomicsDB; 83342; -. [Q9NZ94-2]
DR   ABCD; Q9NZ94; 1 sequenced antibody.
DR   Antibodypedia; 561; 312 antibodies from 37 providers.
DR   DNASU; 54413; -.
DR   Ensembl; ENST00000358741.4; ENSP00000351591.4; ENSG00000196338.15. [Q9NZ94-1]
DR   Ensembl; ENST00000374051.7; ENSP00000363163.3; ENSG00000196338.15. [Q9NZ94-2]
DR   Ensembl; ENST00000536169.6; ENSP00000445298.1; ENSG00000196338.15. [Q9NZ94-3]
DR   GeneID; 54413; -.
DR   KEGG; hsa:54413; -.
DR   MANE-Select; ENST00000358741.4; ENSP00000351591.4; NM_181303.2; NP_851820.1.
DR   CTD; 54413; -.
DR   DisGeNET; 54413; -.
DR   GeneCards; NLGN3; -.
DR   HGNC; HGNC:14289; NLGN3.
DR   HPA; ENSG00000196338; Tissue enhanced (brain, seminal vesicle).
DR   MalaCards; NLGN3; -.
DR   MIM; 300336; gene.
DR   MIM; 300425; phenotype.
DR   MIM; 300494; phenotype.
DR   neXtProt; NX_Q9NZ94; -.
DR   OpenTargets; ENSG00000196338; -.
DR   Orphanet; 1162; NON RARE IN EUROPE: Asperger syndrome.
DR   Orphanet; 106; NON RARE IN EUROPE: Autism.
DR   PharmGKB; PA31649; -.
DR   VEuPathDB; HostDB:ENSG00000196338; -.
DR   eggNOG; KOG1516; Eukaryota.
DR   GeneTree; ENSGT00940000159580; -.
DR   HOGENOM; CLU_006586_5_1_1; -.
DR   InParanoid; Q9NZ94; -.
DR   OMA; MPVWFTS; -.
DR   PhylomeDB; Q9NZ94; -.
DR   TreeFam; TF326187; -.
DR   PathwayCommons; Q9NZ94; -.
DR   Reactome; R-HSA-6794361; Neurexins and neuroligins.
DR   SignaLink; Q9NZ94; -.
DR   SIGNOR; Q9NZ94; -.
DR   BioGRID-ORCS; 54413; 13 hits in 699 CRISPR screens.
DR   ChiTaRS; NLGN3; human.
DR   GeneWiki; NLGN3; -.
DR   GenomeRNAi; 54413; -.
DR   Pharos; Q9NZ94; Tbio.
DR   PRO; PR:Q9NZ94; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q9NZ94; protein.
DR   Bgee; ENSG00000196338; Expressed in cortical plate and 138 other tissues.
DR   ExpressionAtlas; Q9NZ94; baseline and differential.
DR   Genevisible; Q9NZ94; HS.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0098985; C:asymmetric, glutamatergic, excitatory synapse; TAS:ARUK-UCL.
DR   GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR   GO; GO:0030139; C:endocytic vesicle; ISS:BHF-UCL.
DR   GO; GO:0060076; C:excitatory synapse; IDA:BHF-UCL.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0099055; C:integral component of postsynaptic membrane; ISS:BHF-UCL.
DR   GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0089717; C:spanning component of membrane; TAS:ARUK-UCL.
DR   GO; GO:0098983; C:symmetric, GABA-ergic, inhibitory synapse; TAS:ARUK-UCL.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:0050839; F:cell adhesion molecule binding; ISS:BHF-UCL.
DR   GO; GO:0042043; F:neurexin family protein binding; ISS:BHF-UCL.
DR   GO; GO:0097110; F:scaffold protein binding; IPI:BHF-UCL.
DR   GO; GO:0038023; F:signaling receptor activity; ISS:BHF-UCL.
DR   GO; GO:0030534; P:adult behavior; IMP:BHF-UCL.
DR   GO; GO:0048675; P:axon extension; ISS:BHF-UCL.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0060080; P:inhibitory postsynaptic potential; ISS:BHF-UCL.
DR   GO; GO:0007612; P:learning; IMP:BHF-UCL.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; ISS:BHF-UCL.
DR   GO; GO:0007158; P:neuron cell-cell adhesion; ISS:BHF-UCL.
DR   GO; GO:2000969; P:positive regulation of AMPA receptor activity; ISS:BHF-UCL.
DR   GO; GO:2000463; P:positive regulation of excitatory postsynaptic potential; ISS:BHF-UCL.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; ISS:BHF-UCL.
DR   GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.
DR   GO; GO:0097104; P:postsynaptic membrane assembly; ISS:BHF-UCL.
DR   GO; GO:0099054; P:presynapse assembly; TAS:ARUK-UCL.
DR   GO; GO:0097105; P:presynaptic membrane assembly; ISS:BHF-UCL.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; ISS:BHF-UCL.
DR   GO; GO:0002087; P:regulation of respiratory gaseous exchange by nervous system process; ISS:BHF-UCL.
DR   GO; GO:0060024; P:rhythmic synaptic transmission; ISS:BHF-UCL.
DR   GO; GO:0035176; P:social behavior; IMP:UniProtKB.
DR   GO; GO:0007416; P:synapse assembly; ISS:BHF-UCL.
DR   GO; GO:0050808; P:synapse organization; IMP:UniProtKB.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR   GO; GO:0071625; P:vocalization behavior; IMP:BHF-UCL.
DR   DisProt; DP00553; -.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000460; Nlgn.
DR   InterPro; IPR030024; NLGN3.
DR   PANTHER; PTHR43903:SF4; PTHR43903:SF4; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   PRINTS; PR01090; NEUROLIGIN.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Asperger syndrome; Autism; Autism spectrum disorder;
KW   Cell adhesion; Cell membrane; Disease variant; Disulfide bond;
KW   Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal;
KW   Synapse; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..848
FT                   /note="Neuroligin-3"
FT                   /id="PRO_0000008645"
FT   TOPO_DOM        38..709
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        710..730
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        731..848
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          170..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..689
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         745
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62889"
FT   MOD_RES         792
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BYM5"
FT   CARBOHYD        98
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        545
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        106..141
FT                   /evidence="ECO:0000250"
FT   DISULFID        340..351
FT                   /evidence="ECO:0000250"
FT   DISULFID        510..544
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         153..192
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_053827"
FT   VAR_SEQ         153..172
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10767552,
FT                   ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:20034102"
FT                   /id="VSP_007534"
FT   VARIANT         92
FT                   /note="S -> Y (in dbSNP:rs17854698)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_068887"
FT   VARIANT         451
FT                   /note="R -> C (in AUTSX1 and ASPGX1)"
FT                   /evidence="ECO:0000269|PubMed:12669065"
FT                   /id="VAR_015668"
FT   VARIANT         718
FT                   /note="L -> I (in dbSNP:rs17854697)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_068888"
FT   VARIANT         751
FT                   /note="G -> W (in dbSNP:rs17857400)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_068889"
FT   VARIANT         778
FT                   /note="G -> S (in dbSNP:rs17857401)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_068890"
FT   CONFLICT        224
FT                   /note="L -> P (in Ref. 1; AAF71230)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        274
FT                   /note="F -> S (in Ref. 3; BAG37248)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   848 AA;  93895 MW;  B3EE2FAB7E427C82 CRC64;
     MWLRLGPPSL SLSPKPTVGR SLCLTLWFLS LALRASTQAP APTVNTHFGK LRGARVPLPS
     EILGPVDQYL GVPYAAPPIG EKRFLPPEPP PSWSGIRNAT HFPPVCPQNI HTAVPEVMLP
     VWFTANLDIV ATYIQEPNED CLYLNVYVPT EDVKRISKEC ARKPNKKICR KGGSGAKKQG
     EDLADNDGDE DEDIRDSGAK PVMVYIHGGS YMEGTGNMID GSILASYGNV IVITLNYRVG
     VLGFLSTGDQ AAKGNYGLLD QIQALRWVSE NIAFFGGDPR RITVFGSGIG ASCVSLLTLS
     HHSEGLFQRA IIQSGSALSS WAVNYQPVKY TSLLADKVGC NVLDTVDMVD CLRQKSAKEL
     VEQDIQPARY HVAFGPVIDG DVIPDDPEIL MEQGEFLNYD IMLGVNQGEG LKFVEGVVDP
     EDGVSGTDFD YSVSNFVDNL YGYPEGKDTL RETIKFMYTD WADRDNPETR RKTLVALFTD
     HQWVEPSVVT ADLHARYGSP TYFYAFYHHC QSLMKPAWSD AAHGDEVPYV FGVPMVGPTD
     LFPCNFSKND VMLSAVVMTY WTNFAKTGDP NKPVPQDTKF IHTKANRFEE VAWSKYNPRD
     QLYLHIGLKP RVRDHYRATK VAFWKHLVPH LYNLHDMFHY TSTTTKVPPP DTTHSSHITR
     RPNGKTWSTK RPAISPAYSN ENAQGSWNGD QDAGPLLVEN PRDYSTELSV TIAVGASLLF
     LNVLAFAALY YRKDKRRQEP LRQPSPQRGA GAPELGAAPE EELAALQLGP THHECEAGPP
     HDTLRLTALP DYTLTLRRSP DDIPLMTPNT ITMIPNSLVG LQTLHPYNTF AAGFNSTGLP
     HSHSTTRV
 
 
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