ID   NLGN3_MACMU             Reviewed;         202 AA.
AC   Q8WMH2;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Neuroligin-3;
DE   AltName: Full=Gliotactin homolog;
DE   Flags: Fragment;
GN   Name=NLGN3;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RA   Mungenast A.E., Ojeda S.R.;
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cell surface protein involved in cell-cell-interactions via
CC       its interactions with neurexin family members. Plays a role in synapse
CC       function and synaptic signal transmission, and probably mediates its
CC       effects by recruiting and clustering other synaptic proteins. May
CC       promote the initial formation of synapses, but is not essential for
CC       this. May also play a role in glia-glia or glia-neuron interactions in
CC       the developing peripheral nervous system (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-
CC       terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity).
CC       Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Detected at
CC       both glutamatergic and GABAergic synapses. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000305}.
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DR   EMBL; AF424850; AAL40263.1; -; mRNA.
DR   AlphaFoldDB; Q8WMH2; -.
DR   SMR; Q8WMH2; -.
DR   STRING; 9544.ENSMMUP00000023407; -.
DR   ESTHER; macmu-3neur; Neuroligin.
DR   MEROPS; S09.963; -.
DR   eggNOG; KOG1516; Eukaryota.
DR   HOGENOM; CLU_1363181_0_0_1; -.
DR   InParanoid; Q8WMH2; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IBA:GO_Central.
DR   GO; GO:0098984; C:neuron to neuron synapse; IEA:UniProt.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0089717; C:spanning component of membrane; IEA:UniProt.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0042043; F:neurexin family protein binding; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0007158; P:neuron cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0097104; P:postsynaptic membrane assembly; IBA:GO_Central.
DR   GO; GO:0097105; P:presynaptic membrane assembly; IBA:GO_Central.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR000460; Nlgn.
DR   InterPro; IPR030024; NLGN3.
DR   PANTHER; PTHR43903:SF4; PTHR43903:SF4; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   PRINTS; PR01090; NEUROLIGIN.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein; Membrane;
KW   Reference proteome; Synapse.
FT   CHAIN           <1..>202
FT                   /note="Neuroligin-3"
FT                   /id="PRO_0000070298"
FT   TOPO_DOM        <1..>202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          154..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        15..49
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         202
SQ   SEQUENCE   202 AA;  22897 MW;  99602C5B7C28E158 CRC64;
     RYGSPTYFYA FYHHCQSLMK PAWSDAAHGD EVPYVFGVPM VGPTDLFPCN FSKNDVMLSA
     VVMTYWTNFA KTGDPNKPVP QDTKFIHTKA NRFEEVAWSK YNPRDQLYLH IGLKPRVRDH
     YRATKVAFWK HLVPHLYNLH DMFHYTSTTT KVPLRIPPTA PTSPAGPMAR PGAPSGQPSH
     LPTATRMPRG PGTGTRMQGH SW