ID   NLP13_PHYCP             Reviewed;         136 AA.
AC   L7NCQ1;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   03-AUG-2022, entry version 14.
DE   RecName: Full=NLP effector protein 13 {ECO:0000303|PubMed:24886309};
DE   AltName: Full=Necrosis-inducing protein 13 {ECO:0000303|PubMed:21644208};
DE   AltName: Full=Nep1-like protein 13 {ECO:0000303|PubMed:21644208};
GN   Name=NLP13 {ECO:0000303|PubMed:24886309};
GN   Synonyms=NPP13 {ECO:0000303|PubMed:21644208};
OS   Phytophthora capsici.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4784;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DOMAIN.
RX   PubMed=21644208; DOI=10.4238/vol10-2gmr1248;
RA   Feng B.Z., Li P.Q., Fu L., Sun B.B., Zhang X.G.;
RT   "Identification of 18 genes encoding necrosis-inducing proteins from the
RT   plant pathogen Phytophthora capsici (Pythiaceae: Oomycetes).";
RL   Genet. Mol. Res. 10:910-922(2011).
RN   [2]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=24886309; DOI=10.1186/1471-2229-14-126;
RA   Feng B.Z., Zhu X.P., Fu L., Lv R.F., Storey D., Tooley P., Zhang X.G.;
RT   "Characterization of necrosis-inducing NLP proteins in Phytophthora
RT   capsici.";
RL   BMC Plant Biol. 14:126-126(2014).
CC   -!- FUNCTION: Secreted effector that contributes moderately to virulence
CC       during infection by P.capsici. Causes only small yellow areas at 3 days
CC       after inoculation of host C.annuum leaves; these areas expand somewhat
CC       and became necrotic at 7 days after inoculation. Leads only to
CC       chlorotic areas, without necrosis at 7 days after non-host
CC       N.benthamiana leaves infection. {ECO:0000269|PubMed:24886309}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21644208}.
CC   -!- INDUCTION: Expression gradually increases to a maximum at 7 days after
CC       inoculation of pepper leaves. {ECO:0000269|PubMed:24886309}.
CC   -!- DOMAIN: The structure of NLP effectors is remarkably conserved with a
CC       high level of conservation of a central hepta-peptide motif GHRHDWE.
CC       {ECO:0000305|PubMed:21644208}.
CC   -!- SIMILARITY: Belongs to the Necrosis inducing protein (NPP1) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HM543179; AEJ88244.1; -; Genomic_DNA.
DR   AlphaFoldDB; L7NCQ1; -.
DR   SMR; L7NCQ1; -.
DR   VEuPathDB; FungiDB:DVH05_013302; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008701; NPP1.
DR   PANTHER; PTHR33657; PTHR33657; 1.
DR   Pfam; PF05630; NPP1; 1.
PE   2: Evidence at transcript level;
KW   Secreted; Virulence.
FT   CHAIN           1..136
FT                   /note="NLP effector protein 13"
FT                   /id="PRO_0000447426"
FT   MOTIF           16..22
FT                   /note="Hepta-peptide GHRHDWE motif"
FT                   /evidence="ECO:0000305|PubMed:24886309"
SQ   SEQUENCE   136 AA;  15085 MW;  E7CE5F58BC9814FB CRC64;
     MYSWYFPKDS PSTGLGHRHD WEHVIVWIDN PEVPEPKILG VTPSAHSGYS SQVPPDADKV
     DGSSVKVKYL SKWPINHALE STGEGGDFQD LIMWTQMTDA AREGLSKTGW GKANVPMVDG
     NFEAKLGKAW PFGEKK