NLP28_CAEEL
ID NLP28_CAEEL Reviewed; 65 AA.
AC O44665;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Neuropeptide-like protein 28;
DE Contains:
DE RecName: Full=QWGYGGY-amide;
DE Contains:
DE RecName: Full=GYGGYGGY-amide;
DE Contains:
DE RecName: Full=GMYGGY-amide;
DE Contains:
DE RecName: Full=GMYGGW-amide;
DE Flags: Precursor;
GN Name=nlp-28; ORFNames=B0213.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=11717458; DOI=10.1073/pnas.241231298;
RA Nathoo A.N., Moeller R.A., Westlund B.A., Hart A.C.;
RT "Identification of neuropeptide-like protein gene families in
RT Caenorhabditis elegans and other species.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:14000-14005(2001).
CC -!- FUNCTION: May have antimicrobial activity.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the YARP (YGGW-amide related peptide) family.
CC {ECO:0000305}.
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DR EMBL; FO080121; CCD61353.1; -; Genomic_DNA.
DR PIR; D89016; D89016.
DR RefSeq; NP_504110.1; NM_071709.4.
DR AlphaFoldDB; O44665; -.
DR BioGRID; 46713; 1.
DR STRING; 6239.B0213.3; -.
DR EPD; O44665; -.
DR PaxDb; O44665; -.
DR EnsemblMetazoa; B0213.3.1; B0213.3.1; WBGene00003766.
DR GeneID; 181845; -.
DR KEGG; cel:CELE_B0213.3; -.
DR UCSC; B0213.3; c. elegans.
DR CTD; 181845; -.
DR WormBase; B0213.3; CE16774; WBGene00003766; nlp-28.
DR HOGENOM; CLU_193227_0_0_1; -.
DR OMA; MATSAQW; -.
DR PRO; PR:O44665; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003766; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PEPTIDE 23..29
FT /note="QWGYGGY-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000041488"
FT PEPTIDE 32..39
FT /note="GYGGYGGY-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000041489"
FT PEPTIDE 42..47
FT /note="GMYGGY-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000041490"
FT PEPTIDE 50..55
FT /note="GMYGGY-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000041491"
FT PEPTIDE 58..63
FT /note="GMYGGW-amide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000041492"
FT MOD_RES 29
FT /note="Tyrosine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 39
FT /note="Tyrosine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 47
FT /note="Tyrosine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 55
FT /note="Tyrosine amide"
FT /evidence="ECO:0000255"
FT MOD_RES 63
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 65 AA; 6867 MW; B149BDCA7C4CADDC CRC64;
MISTSSILIL VFLLACFMAT SAQWGYGGYG RGYGGYGGYG RGMYGGYGRG MYGGYGRGMY
GGWGK
