ID   NLP30_CAEEL             Reviewed;          69 AA.
AC   O44663;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Neuropeptide-like protein 30;
DE   Contains:
DE     RecName: Full=QWGYGGY-amide;
DE   Contains:
DE     RecName: Full=GYGGYGGY-amide;
DE   Contains:
DE     RecName: Full=GYGGY-amide;
DE   Contains:
DE     RecName: Full=GMW-amide;
DE   Contains:
DE     RecName: Full=PYGGYGW-amide;
DE   Flags: Precursor;
GN   Name=nlp-30; ORFNames=B0213.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=11717458; DOI=10.1073/pnas.241231298;
RA   Nathoo A.N., Moeller R.A., Westlund B.A., Hart A.C.;
RT   "Identification of neuropeptide-like protein gene families in
RT   Caenorhabditis elegans and other species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:14000-14005(2001).
RN   [3]
RP   FUNCTION, AND INDUCTION BY FUNGAL INFECTION.
RX   PubMed=19380113; DOI=10.1016/j.chom.2009.03.006;
RA   Ziegler K., Kurz C.L., Cypowyj S., Couillault C., Pophillat M., Pujol N.,
RA   Ewbank J.J.;
RT   "Antifungal innate immunity in C. elegans: PKCdelta links G protein
RT   signaling and a conserved p38 MAPK cascade.";
RL   Cell Host Microbe 5:341-352(2009).
CC   -!- FUNCTION: May have antimicrobial activity. May play a role in response
CC       to fungal infection. {ECO:0000303|PubMed:19380113}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in hypoderm.
CC       {ECO:0000269|PubMed:11717458}.
CC   -!- INDUCTION: Upon D.coniospora infection. {ECO:0000269|PubMed:19380113}.
CC   -!- SIMILARITY: Belongs to the YARP (YGGW-amide related peptide) family.
CC       {ECO:0000305}.
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DR   EMBL; FO080121; CCD61355.1; -; Genomic_DNA.
DR   PIR; B89016; B89016.
DR   RefSeq; NP_504108.1; NM_071707.3.
DR   AlphaFoldDB; O44663; -.
DR   STRING; 6239.B0213.5; -.
DR   PaxDb; O44663; -.
DR   EnsemblMetazoa; B0213.5.1; B0213.5.1; WBGene00003768.
DR   GeneID; 3565444; -.
DR   KEGG; cel:CELE_B0213.5; -.
DR   UCSC; B0213.5; c. elegans.
DR   CTD; 3565444; -.
DR   WormBase; B0213.5; CE16776; WBGene00003768; nlp-30.
DR   HOGENOM; CLU_193227_0_0_1; -.
DR   OMA; ACIYSVQ; -.
DR   PRO; PR:O44663; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003768; Expressed in larva and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..29
FT                   /note="QWGYGGY-amide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000041499"
FT   PEPTIDE         32..39
FT                   /note="GYGGYGGY-amide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000041500"
FT   PEPTIDE         42..46
FT                   /note="GYGGY-amide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000041501"
FT   PEPTIDE         49..53
FT                   /note="GYGGY-amide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000041502"
FT   PEPTIDE         55..58
FT                   /note="GMW-amide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000041503"
FT   PEPTIDE         61..67
FT                   /note="PYGGYGW-amide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000041504"
FT   MOD_RES         29
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         39
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         46
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         53
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         58
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         67
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   69 AA;  7243 MW;  05D666FF2390092E CRC64;
     MISTSSILIL VVLLACFMAA SAQWGYGGYG RGYGGYGGYG RGYGGYGRGY GGYGRGMWGR
     PYGGYGWGK