ID   NLP33_CAEEL             Reviewed;          74 AA.
AC   Q95ZN4;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Neuropeptide-like protein 33;
DE   Flags: Precursor;
GN   Name=nlp-33; ORFNames=T19C4.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=15048112; DOI=10.1038/ni1060;
RA   Couillault C., Pujol N., Reboul J., Sabatier L., Guichou J.-F., Kohara Y.,
RA   Ewbank J.J.;
RT   "TLR-independent control of innate immunity in Caenorhabditis elegans by
RT   the TIR domain adaptor protein TIR-1, an ortholog of human SARM.";
RL   Nat. Immunol. 5:488-494(2004).
CC   -!- FUNCTION: May have antifungic activity against D.coniospora.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in hypoderm.
CC       {ECO:0000269|PubMed:15048112}.
CC   -!- INDUCTION: Strongly up-regulated upon D.coniospora infection.
CC       {ECO:0000269|PubMed:15048112}.
CC   -!- SIMILARITY: Belongs to the YARP (YGGW-amide related peptide) family.
CC       {ECO:0000305}.
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DR   EMBL; Z75549; CAC42343.1; -; Genomic_DNA.
DR   RefSeq; NP_505834.1; NM_073433.5.
DR   AlphaFoldDB; Q95ZN4; -.
DR   SMR; Q95ZN4; -.
DR   STRING; 6239.T19C4.7; -.
DR   PaxDb; Q95ZN4; -.
DR   PeptideAtlas; Q95ZN4; -.
DR   EnsemblMetazoa; T19C4.7.1; T19C4.7.1; WBGene00003771.
DR   GeneID; 179545; -.
DR   KEGG; cel:CELE_T19C4.7; -.
DR   UCSC; T19C4.7; c. elegans.
DR   CTD; 179545; -.
DR   WormBase; T19C4.7; CE27777; WBGene00003771; nlp-33.
DR   eggNOG; ENOG502TIA6; Eukaryota.
DR   HOGENOM; CLU_193227_0_0_1; -.
DR   OMA; PYGGWYG; -.
DR   PRO; PR:Q95ZN4; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003771; Expressed in larva and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Antimicrobial; Fungicide; Neuropeptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..72
FT                   /note="Neuropeptide-like protein 33"
FT                   /id="PRO_0000041521"
FT   MOD_RES         72
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   74 AA;  7650 MW;  16892EFAD8DA5DDC CRC64;
     MISTSLLLVV LLFAILAIVD AQWGYGGPYG GYGGGYGGGP WGYGGGWRRR HWGGYGGGPW
     GGYGGGPWGG YYGK