NLP38_CAEEL
ID NLP38_CAEEL Reviewed; 120 AA.
AC G3MU46; Q8T3G1;
DT 26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Neuropeptide-like protein 38 {ECO:0000305};
DE AltName: Full=Myoinhibitory-like protein homolog {ECO:0000303|PubMed:30779740};
DE Contains:
DE RecName: Full=MIP-1-1 {ECO:0000303|PubMed:30779740};
DE Contains:
DE RecName: Full=MIP-1-2 {ECO:0000303|PubMed:30779740};
DE Contains:
DE RecName: Full=MIP-1-5 {ECO:0000303|PubMed:30779740};
DE Flags: Precursor;
GN Name=nlp-38 {ECO:0000312|WormBase:C01A2.7b};
GN ORFNames=C01A2.7 {ECO:0000312|WormBase:C01A2.7b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND AMIDATION AT TRP-35; TRP-60 AND TRP-118.
RX PubMed=30779740; DOI=10.1371/journal.pgen.1007945;
RA Peymen K., Watteyne J., Borghgraef C., Van Sinay E., Beets I., Schoofs L.;
RT "Myoinhibitory peptide signaling modulates aversive gustatory learning in
RT Caenorhabditis elegans.";
RL PLoS Genet. 15:E1007945-E1007945(2019).
CC -!- FUNCTION: Plays a role in several types of aversive gustatory
CC associative learning including gustatory plasticity and salt avoidance
CC learning. {ECO:0000269|PubMed:30779740}.
CC -!- FUNCTION: [MIP-1-1]: Neuropeptide ligand for the G-protein coupled
CC receptor sprr-2. {ECO:0000269|PubMed:30779740}.
CC -!- FUNCTION: [MIP-1-2]: Neuropeptide ligand for the G-protein coupled
CC receptor sprr-2. {ECO:0000269|PubMed:30779740}.
CC -!- FUNCTION: [MIP-1-5]: Neuropeptide ligand for the G-protein coupled
CC receptor sprr-2. {ECO:0000269|PubMed:30779740}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:C01A2.7b};
CC IsoId=G3MU46-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:C01A2.7a};
CC IsoId=G3MU46-2; Sequence=VSP_060479;
CC -!- TISSUE SPECIFICITY: Expressed in the ventral and dorsal nerve cords and
CC ventral nerve cord motor neurons (PubMed:30779740). Also expressed in
CC tail neurons and head neurons including SAB and DBI motor neurons
CC (PubMed:30779740). {ECO:0000269|PubMed:30779740}.
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DR EMBL; BX284601; CAD24480.1; -; Genomic_DNA.
DR EMBL; BX284601; CCD31026.1; -; Genomic_DNA.
DR RefSeq; NP_001252154.1; NM_001265225.1. [G3MU46-1]
DR RefSeq; NP_001252155.1; NM_001265226.1. [G3MU46-2]
DR AlphaFoldDB; G3MU46; -.
DR SMR; G3MU46; -.
DR STRING; 6239.C01A2.7b; -.
DR PaxDb; G3MU46; -.
DR EnsemblMetazoa; C01A2.7a.1; C01A2.7a.1; WBGene00007219. [G3MU46-2]
DR EnsemblMetazoa; C01A2.7b.1; C01A2.7b.1; WBGene00007219. [G3MU46-1]
DR GeneID; 173209; -.
DR KEGG; cel:CELE_C01A2.7; -.
DR UCSC; C01A2.7.1; c. elegans.
DR CTD; 173209; -.
DR WormBase; C01A2.7a; CE30236; WBGene00007219; nlp-38. [G3MU46-2]
DR WormBase; C01A2.7b; CE46120; WBGene00007219; nlp-38. [G3MU46-1]
DR eggNOG; ENOG502TI28; Eukaryota.
DR GeneTree; ENSGT00940000176783; -.
DR HOGENOM; CLU_166338_0_0_1; -.
DR InParanoid; G3MU46; -.
DR OMA; QWQRANG; -.
DR OrthoDB; 1344573at2759; -.
DR PRO; PR:G3MU46; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00007219; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Alternative splicing; Amidation; Behavior; Chemotaxis;
KW Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..24
FT /evidence="ECO:0000305"
FT /id="PRO_0000448950"
FT PEPTIDE 25..35
FT /note="MIP-1-1"
FT /evidence="ECO:0000303|PubMed:30779740"
FT /id="PRO_0000448951"
FT PROPEP 39..46
FT /evidence="ECO:0000305"
FT /id="PRO_0000448952"
FT PEPTIDE 49..60
FT /note="MIP-1-2"
FT /evidence="ECO:0000303|PubMed:30779740"
FT /id="PRO_0000448953"
FT PROPEP 64..85
FT /evidence="ECO:0000305"
FT /id="PRO_0000448954"
FT PEPTIDE 88..118
FT /note="MIP-1-5"
FT /evidence="ECO:0000303|PubMed:30779740"
FT /id="PRO_0000448955"
FT MOD_RES 35
FT /note="Tryptophan amide"
FT /evidence="ECO:0000305|PubMed:30779740"
FT MOD_RES 60
FT /note="Tryptophan amide"
FT /evidence="ECO:0000305|PubMed:30779740"
FT MOD_RES 118
FT /note="Tryptophan amide"
FT /evidence="ECO:0000305|PubMed:30779740"
FT VAR_SEQ 88..106
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_060479"
SQ SEQUENCE 120 AA; 13696 MW; 451D8A1D71DA8280 CRC64;
MQLIHFIVGL AMLISLSLAA SDDRVLGWNK AHGLWGKRSV QEASQDKRTP QNWNKLNSLW
GKRSASSFDD DYTTENGDDD VTMLYKRSNL SPRFLGRMTF ARIPKISPAQ WQRANGLWGR
