NLP6_ARATH
ID NLP6_ARATH Reviewed; 841 AA.
AC Q8RWY4; Q8H105; Q9SGW2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Protein NLP6;
DE Short=AtNLP6;
DE AltName: Full=NIN-like protein 6;
DE AltName: Full=Nodule inception protein-like protein 6;
GN Name=NLP6; OrderedLocusNames=At1g64530; ORFNames=F1N19.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15785851; DOI=10.1007/s00239-004-0144-2;
RA Schauser L., Wieloch W., Stougaard J.;
RT "Evolution of NIN-like proteins in Arabidopsis, rice, and Lotus
RT japonicus.";
RL J. Mol. Evol. 60:229-237(2005).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=18826430; DOI=10.1111/j.1365-313x.2008.03695.x;
RA Castaings L., Camargo A., Pocholle D., Gaudon V., Texier Y.,
RA Boutet-Mercey S., Taconnat L., Renou J.P., Daniel-Vedele F., Fernandez E.,
RA Meyer C., Krapp A.;
RT "The nodule inception-like protein 7 modulates nitrate sensing and
RT metabolism in Arabidopsis.";
RL Plant J. 57:426-435(2009).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00852}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:18826430}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF19672.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009519; AAF19672.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34250.1; -; Genomic_DNA.
DR EMBL; AY091029; AAM13850.1; -; mRNA.
DR EMBL; BT000933; AAN41333.1; -; mRNA.
DR RefSeq; NP_176634.1; NM_105128.5.
DR AlphaFoldDB; Q8RWY4; -.
DR SMR; Q8RWY4; -.
DR BioGRID; 27982; 2.
DR IntAct; Q8RWY4; 2.
DR STRING; 3702.AT1G64530.1; -.
DR iPTMnet; Q8RWY4; -.
DR PaxDb; Q8RWY4; -.
DR PRIDE; Q8RWY4; -.
DR ProteomicsDB; 251152; -.
DR EnsemblPlants; AT1G64530.1; AT1G64530.1; AT1G64530.
DR GeneID; 842761; -.
DR Gramene; AT1G64530.1; AT1G64530.1; AT1G64530.
DR KEGG; ath:AT1G64530; -.
DR Araport; AT1G64530; -.
DR TAIR; locus:2019424; AT1G64530.
DR eggNOG; ENOG502QQ6H; Eukaryota.
DR HOGENOM; CLU_008971_0_0_1; -.
DR InParanoid; Q8RWY4; -.
DR OrthoDB; 255222at2759; -.
DR PhylomeDB; Q8RWY4; -.
DR PRO; PR:Q8RWY4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RWY4; baseline and differential.
DR Genevisible; Q8RWY4; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR CDD; cd06407; PB1_NLP; 1.
DR InterPro; IPR045012; NLP.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR034891; PB1_NLP.
DR InterPro; IPR003035; RWP-RK_dom.
DR PANTHER; PTHR32002; PTHR32002; 2.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF02042; RWP-RK; 1.
DR SMART; SM00666; PB1; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS51519; RWP_RK; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..841
FT /note="Protein NLP6"
FT /id="PRO_0000401491"
FT DOMAIN 539..624
FT /note="RWP-RK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00852"
FT DOMAIN 741..823
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REGION 649..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 311
FT /note="H -> Y (in Ref. 3; AAM13850)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 841 AA; 93863 MW; 9BD0EF249F54C3D3 CRC64;
MELDDLDLSG SWPLDQITFA SNFKSPVIFS SSEQPFSPLW SFSETSGDVG GELYSAAVAP
TRFTDYSVLL ASSESETTTK ENNQVPSPSW GIMPLENPDS YCAIKAKMTQ ALRYFKESTG
QQHVLAQVWA PVKNRGRYVL TTSGQPFVLG PNSNGLNQYR MVSLTYMFSL DGERDGELGL
PGRVFRKKLP EWTPNVQYYS SKEFSRLGHA LHYNVQGTLA LPVFEPSRQL CVGVVELIMT
SPKINYAPEV EKVCKALEAV NLKTSEILNH ETTQICNEGR QNALAEILEI LTVVCETYKL
PLAQTWVPCR HRSVLAFGGG FKKSCSSFDG SCMGKVCMST SDLAVYVVDA HVWGFRDACA
EHHLQKGQGV AGRAFQSGNL CFCRDVTRFC KTDYPLVHYA RMFKLTSCFA VCLKSTYTGD
DEYVLEFFLP PAITDKSEQD CLLGSLLQTM KQHYSSLKVV SETELCENNM SLEVVEASED
GMVYSKLEPI RIHHPAQISK DYLELNAPEQ KVSLNSDFME NNEVDDGVER FQTLDPIPEA
KTVKKSERKR GKTEKTISLE VLQQYFAGSL KDAAKSLGVC PTTMKRICRQ HGISRWPSRK
INKVNRSLTR LKHVIDSVQG ADGSLNLTSL SPRPWPHQIP PIDIQLAKNC PPTSTSPLSN
LQDVKIENRD AEDSAGSSTS RASCKVNPIC ETRFRLPTHN QEPSRQVALD DSDSSSKNMT
NFWAHLTCQD TASPTILQHK LVSIKATYRE DIIRFKISPE SVSITELKQQ VAKRLKLETA
AFELKYLDDD REWVSVSCDA DLSECLDTSA AKANTLRLSV HDVTFNFGSS CESSEETMMC
L
