NLP6_PHYCP
ID NLP6_PHYCP Reviewed; 338 AA.
AC L7NCR1;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 1.
DT 03-AUG-2022, entry version 16.
DE RecName: Full=NLP effector protein 6 {ECO:0000303|PubMed:24886309};
DE AltName: Full=Necrosis-inducing protein 6 {ECO:0000303|PubMed:21644208};
DE AltName: Full=Nep1-like protein 6 {ECO:0000303|PubMed:21644208};
DE Flags: Precursor;
GN Name=NLP6 {ECO:0000303|PubMed:24886309};
GN Synonyms=NPP6 {ECO:0000303|PubMed:21644208};
OS Phytophthora capsici.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4784;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DOMAIN.
RX PubMed=21644208; DOI=10.4238/vol10-2gmr1248;
RA Feng B.Z., Li P.Q., Fu L., Sun B.B., Zhang X.G.;
RT "Identification of 18 genes encoding necrosis-inducing proteins from the
RT plant pathogen Phytophthora capsici (Pythiaceae: Oomycetes).";
RL Genet. Mol. Res. 10:910-922(2011).
RN [2]
RP INDUCTION, AND FUNCTION.
RX PubMed=24886309; DOI=10.1186/1471-2229-14-126;
RA Feng B.Z., Zhu X.P., Fu L., Lv R.F., Storey D., Tooley P., Zhang X.G.;
RT "Characterization of necrosis-inducing NLP proteins in Phytophthora
RT capsici.";
RL BMC Plant Biol. 14:126-126(2014).
CC -!- FUNCTION: Secreted effector that contributes strongly to virulence
CC during infection by P.capsici. Causes large necrotic areas in both host
CC C.annuum and non-host N.benthamiana. {ECO:0000269|PubMed:24886309}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21644208}.
CC -!- INDUCTION: Expression reached the highest levels at 3 days after
CC inoculation of pepper leaves, followed by a gradual decline.
CC {ECO:0000269|PubMed:24886309}.
CC -!- DOMAIN: The structure of NLP effectors is remarkably conserved with a
CC high level of conservation of a central hepta-peptide motif GHRHDWE.
CC {ECO:0000305|PubMed:21644208}.
CC -!- SIMILARITY: Belongs to the Necrosis inducing protein (NPP1) family.
CC {ECO:0000305}.
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DR EMBL; HM543172; AEJ88237.1; -; Genomic_DNA.
DR AlphaFoldDB; L7NCR1; -.
DR SMR; L7NCR1; -.
DR VEuPathDB; FungiDB:DVH05_001468; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR008701; NPP1.
DR PANTHER; PTHR33657; PTHR33657; 1.
DR Pfam; PF05630; NPP1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Secreted; Signal; Virulence.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..338
FT /note="NLP effector protein 6"
FT /id="PRO_5003982510"
FT REGION 68..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 222..227
FT /note="Hepta-peptide GHRHDWE motif"
FT /evidence="ECO:0000305|PubMed:24886309"
FT COMPBIAS 69..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 338 AA; 37326 MW; F9A91B6B7C1C082D CRC64;
MRFTTIFWIS LTVLATVRAE DGSHAQNEVQ AGDGSHVQNE VQVGSEPQTQ DSIETPKPTI
KYIDFGDLTL SPSASSPAKR NVTLPPDTTM RPDPRQTEPP TEAPTPASTP APTPDPGPWV
DKWIGHDQVK PFPQPEPVTI SEKAGVKFKP QIQIRTGCEP YPAVNEYGET GGGLKTTGKS
RGNCGGSGYG SQVYGRSTWI RGVWAIMYSW YFPKDSPSPK MGHRHDWEHA IVFIDNPEVS
EPKILACSVS SHDGYKKYNP CPSWVIDGTS LKVRYKHAWP LNHDLDATGD GGKFQDSIMW
NQLTEDARRA LNSVSFGKAN TPFNDGKFMP KIENAWPF
