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NLP7_ARATH
ID   NLP7_ARATH              Reviewed;         959 AA.
AC   Q84TH9; O22987;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein NLP7;
DE            Short=AtNLP7;
DE   AltName: Full=NIN-like protein 7;
DE   AltName: Full=Nodule inception protein-like protein 7;
GN   Name=NLP7; OrderedLocusNames=At4g24020; ORFNames=T19F6.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15785851; DOI=10.1007/s00239-004-0144-2;
RA   Schauser L., Wieloch W., Stougaard J.;
RT   "Evolution of NIN-like proteins in Arabidopsis, rice, and Lotus
RT   japonicus.";
RL   J. Mol. Evol. 60:229-237(2005).
RN   [6]
RP   FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION,
RP   AND INDUCTION BY NITRATE.
RX   PubMed=18826430; DOI=10.1111/j.1365-313x.2008.03695.x;
RA   Castaings L., Camargo A., Pocholle D., Gaudon V., Texier Y.,
RA   Boutet-Mercey S., Taconnat L., Renou J.P., Daniel-Vedele F., Fernandez E.,
RA   Meyer C., Krapp A.;
RT   "The nodule inception-like protein 7 modulates nitrate sensing and
RT   metabolism in Arabidopsis.";
RL   Plant J. 57:426-435(2009).
RN   [7]
RP   MUTAGENESIS OF PRO-223.
RX   PubMed=19633234; DOI=10.1104/pp.109.140434;
RA   Wang R., Xing X., Wang Y., Tran A., Crawford N.M.;
RT   "A genetic screen for nitrate regulatory mutants captures the nitrate
RT   transporter gene NRT1.1.";
RL   Plant Physiol. 151:472-478(2009).
RN   [8]
RP   INTERACTION WITH NRG2, AND SUBCELLULAR LOCATION.
RX   PubMed=26744214; DOI=10.1105/tpc.15.00567;
RA   Xu N., Wang R., Zhao L., Zhang C., Li Z., Lei Z., Liu F., Guan P., Chu Z.,
RA   Crawford N.M., Wang Y.;
RT   "The Arabidopsis NRG2 protein mediates nitrate signaling and interacts with
RT   and regulates key nitrate regulators.";
RL   Plant Cell 28:485-504(2016).
CC   -!- FUNCTION: Transcription factor involved in regulation of nitrate
CC       assimilation and in transduction of the nitrate signal.
CC       {ECO:0000269|PubMed:18826430}.
CC   -!- SUBUNIT: Interacts with NRG2. {ECO:0000269|PubMed:26744214}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00852,
CC       ECO:0000269|PubMed:18826430, ECO:0000269|PubMed:26744214}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, flowers and
CC       siliques. Detected in root hairs, emerging secondary roots, vascular
CC       tissues, leaf parenchyma cells and stomata.
CC       {ECO:0000269|PubMed:18826430}.
CC   -!- INDUCTION: Not regulated by the N source or by nitrate.
CC       {ECO:0000269|PubMed:18826430}.
CC   -!- DISRUPTION PHENOTYPE: N-starvation phenotype. Smaller rosette, but no
CC       effects on roots. Delayed growth and flowering when grown in
CC       greenhouse. Increased drought resistance.
CC       {ECO:0000269|PubMed:18826430}.
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DR   EMBL; AC002343; AAB63621.1; -; Genomic_DNA.
DR   EMBL; AL109619; CAB51645.1; -; Genomic_DNA.
DR   EMBL; AL161560; CAB81320.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE84841.1; -; Genomic_DNA.
DR   EMBL; BT005776; AAO64180.1; -; mRNA.
DR   EMBL; AK228452; BAF00379.1; -; mRNA.
DR   PIR; E85276; E85276.
DR   PIR; T08921; T08921.
DR   RefSeq; NP_194133.1; NM_118534.6.
DR   AlphaFoldDB; Q84TH9; -.
DR   SMR; Q84TH9; -.
DR   BioGRID; 13791; 1.
DR   IntAct; Q84TH9; 1.
DR   STRING; 3702.AT4G24020.1; -.
DR   iPTMnet; Q84TH9; -.
DR   PaxDb; Q84TH9; -.
DR   PRIDE; Q84TH9; -.
DR   ProteomicsDB; 249441; -.
DR   EnsemblPlants; AT4G24020.1; AT4G24020.1; AT4G24020.
DR   GeneID; 828502; -.
DR   Gramene; AT4G24020.1; AT4G24020.1; AT4G24020.
DR   KEGG; ath:AT4G24020; -.
DR   Araport; AT4G24020; -.
DR   TAIR; locus:2134941; AT4G24020.
DR   eggNOG; ENOG502QRQ2; Eukaryota.
DR   HOGENOM; CLU_008971_0_0_1; -.
DR   InParanoid; Q84TH9; -.
DR   OMA; VWAPVKE; -.
DR   OrthoDB; 255222at2759; -.
DR   PhylomeDB; Q84TH9; -.
DR   PRO; PR:Q84TH9; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q84TH9; baseline and differential.
DR   Genevisible; Q84TH9; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; IPI:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0042128; P:nitrate assimilation; IMP:TAIR.
DR   GO; GO:0010167; P:response to nitrate; IMP:TAIR.
DR   GO; GO:0009414; P:response to water deprivation; IMP:TAIR.
DR   GO; GO:0010118; P:stomatal movement; IMP:TAIR.
DR   CDD; cd06407; PB1_NLP; 1.
DR   InterPro; IPR045012; NLP.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR034891; PB1_NLP.
DR   InterPro; IPR003035; RWP-RK_dom.
DR   PANTHER; PTHR32002; PTHR32002; 1.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF02042; RWP-RK; 1.
DR   SMART; SM00666; PB1; 1.
DR   PROSITE; PS51745; PB1; 1.
DR   PROSITE; PS51519; RWP_RK; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..959
FT                   /note="Protein NLP7"
FT                   /id="PRO_0000401492"
FT   DOMAIN          578..659
FT                   /note="RWP-RK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00852"
FT   DOMAIN          863..945
FT                   /note="PB1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          633..654
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        673..712
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         223
FT                   /note="P->S: In Mut164; loss of nitrate sensing."
FT                   /evidence="ECO:0000269|PubMed:19633234"
FT   CONFLICT        525
FT                   /note="K -> E (in Ref. 3; AAO64180 and 4; BAF00379)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   959 AA;  105742 MW;  F3F79F77A36D9264 CRC64;
     MCEPDDNSAR NGVTTQPSRS RELLMDVDDL DLDGSWPLDQ IPYLSSSNRM ISPIFVSSSS
     EQPCSPLWAF SDGGGNGFHH ATSGGDDEKI SSVSGVPSFR LAEYPLFLPY SSPSAAENTT
     EKHNSFQFPS PLMSLVPPEN TDNYCVIKER MTQALRYFKE STEQHVLAQV WAPVRKNGRD
     LLTTLGQPFV LNPNGNGLNQ YRMISLTYMF SVDSESDVEL GLPGRVFRQK LPEWTPNVQY
     YSSKEFSRLD HALHYNVRGT LALPVFNPSG QSCIGVVELI MTSEKIHYAP EVDKVCKALE
     AVNLKSSEIL DHQTTQICNE SRQNALAEIL EVLTVVCETH NLPLAQTWVP CQHGSVLANG
     GGLKKNCTSF DGSCMGQICM STTDMACYVV DAHVWGFRDA CLEHHLQKGQ GVAGRAFLNG
     GSCFCRDITK FCKTQYPLVH YALMFKLTTC FAISLQSSYT GDDSYILEFF LPSSITDDQE
     QDLLLGSILV TMKEHFQSLR VASGVDFGED DDKLSFEIIQ ALPDKKVHSK IESIRVPFSG
     FKSNATETML IPQPVVQSSD PVNEKINVAT VNGVVKEKKK TEKKRGKTEK TISLDVLQQY
     FTGSLKDAAK SLGVCPTTMK RICRQHGISR WPSRKIKKVN RSITKLKRVI ESVQGTDGGL
     DLTSMAVSSI PWTHGQTSAQ PLNSPNGSKP PELPNTNNSP NHWSSDHSPN EPNGSPELPP
     SNGHKRSRTV DESAGTPTSH GSCDGNQLDE PKVPNQDPLF TVGGSPGLLF PPYSRDHDVS
     AASFAMPNRL LGSIDHFRGM LIEDAGSSKD LRNLCPTAAF DDKFQDTNWM NNDNNSNNNL
     YAPPKEEAIA NVACEPSGSE MRTVTIKASY KDDIIRFRIS SGSGIMELKD EVAKRLKVDA
     GTFDIKYLDD DNEWVLIACD ADLQECLEIP RSSRTKIVRL LVHDVTTNLG SSCESTGEL
 
 
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