ID   NLP7_CAEEL              Reviewed;         121 AA.
AC   Q19569; H8W3Y5;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Neuropeptide-like protein 7 {ECO:0000312|WormBase:F18E9.2a};
DE   Flags: Precursor;
GN   Name=nlp-7 {ECO:0000312|WormBase:F18E9.2a};
GN   ORFNames=F18E9.2 {ECO:0000312|WormBase:F18E9.2a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19627265; DOI=10.1111/j.1474-9726.2009.00473.x;
RA   Park S.K., Tedesco P.M., Johnson T.E.;
RT   "Oxidative stress and longevity in Caenorhabditis elegans as mediated by
RT   SKN-1.";
RL   Aging Cell 8:258-269(2009).
RN   [3] {ECO:0000305}
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19783783; DOI=10.1096/fj.09-142984;
RA   Park S.K., Link C.D., Johnson T.E.;
RT   "Life-span extension by dietary restriction is mediated by NLP-7 signaling
RT   and coelomocyte endocytosis in C. elegans.";
RL   FASEB J. 24:383-392(2010).
CC   -!- FUNCTION: May regulate lifespan in response to food availability and
CC       oxidative stress. {ECO:0000269|PubMed:19627265,
CC       ECO:0000269|PubMed:19783783}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a {ECO:0000312|WormBase:F18E9.2a};
CC         IsoId=Q19569-1; Sequence=Displayed;
CC       Name=2 {ECO:0000312|WormBase:F18E9.2b};
CC         IsoId=Q19569-2; Sequence=VSP_058545;
CC   -!- INDUCTION: Up-regulated when diet is restricted.
CC       {ECO:0000269|PubMed:19783783}.
CC   -!- DISRUPTION PHENOTYPE: Reduced lifespan when diet is restricted, and in
CC       the presence of the oxidative stress inducer paraquat
CC       (PubMed:19783783). Increased pha-4 and cup-4 expression when diet is
CC       restricted (PubMed:19783783). RNAi-mediated knockdown reduces lifespan
CC       and resistance to the oxidative stress inducer paraquat
CC       (PubMed:19627265, PubMed:19783783). RNAi-mediated knockdown in an eat-2
CC       mutant background rescues lifespan, but lifespan remains greater than
CC       in wild-type (PubMed:19783783). {ECO:0000269|PubMed:19627265,
CC       ECO:0000269|PubMed:19783783}.
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DR   EMBL; BX284606; CCD68426.1; -; Genomic_DNA.
DR   EMBL; BX284606; CCG28151.1; -; Genomic_DNA.
DR   PIR; T16098; T16098.
DR   RefSeq; NP_001257062.1; NM_001270133.1. [Q19569-2]
DR   RefSeq; NP_001257063.1; NM_001270134.1. [Q19569-1]
DR   AlphaFoldDB; Q19569; -.
DR   SMR; Q19569; -.
DR   DIP; DIP-26780N; -.
DR   STRING; 6239.F18E9.2a; -.
DR   PaxDb; Q19569; -.
DR   EnsemblMetazoa; F18E9.2a.1; F18E9.2a.1; WBGene00003745. [Q19569-1]
DR   EnsemblMetazoa; F18E9.2b.1; F18E9.2b.1; WBGene00003745. [Q19569-2]
DR   GeneID; 184647; -.
DR   KEGG; cel:CELE_F18E9.2; -.
DR   UCSC; F18E9.2; c. elegans. [Q19569-1]
DR   CTD; 184647; -.
DR   WormBase; F18E9.2a; CE02659; WBGene00003745; nlp-7. [Q19569-1]
DR   WormBase; F18E9.2b; CE47167; WBGene00003745; nlp-7. [Q19569-2]
DR   eggNOG; ENOG502TI7V; Eukaryota.
DR   InParanoid; Q19569; -.
DR   OMA; YRAIRIQ; -.
DR   OrthoDB; 1548589at2759; -.
DR   PRO; PR:Q19569; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00003745; Expressed in larva and 3 other tissues.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:1901046; P:positive regulation of oviposition; IMP:UniProtKB.
DR   GO; GO:0061771; P:response to caloric restriction; IDA:UniProtKB.
DR   GO; GO:1901562; P:response to paraquat; IMP:UniProtKB.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Neuropeptide; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..121
FT                   /note="Neuropeptide-like protein 7"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5004187338"
FT   VAR_SEQ         110..121
FT                   /note="YFLFSNRLTCRC -> FFSGAFGRK (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_058545"
SQ   SEQUENCE   121 AA;  14079 MW;  CF395E92E12C4470 CRC64;
     MYIKAALLIV VLFGVASQIT SALYLKQADF DDPRMFTSSF GKRSAIESEP QAYPKSYRAI
     RIQRRSMDDL DDPRLMTMSF GKRMILPSLA DLHRYTMYDK RGSDIDDPRY FLFSNRLTCR
     C