NLP7_PHYCP
ID NLP7_PHYCP Reviewed; 318 AA.
AC L7NCQ5;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 1.
DT 03-AUG-2022, entry version 17.
DE RecName: Full=NLP effector protein 7 {ECO:0000303|PubMed:24886309};
DE AltName: Full=Necrosis-inducing protein 7 {ECO:0000303|PubMed:21644208};
DE AltName: Full=Nep1-like protein 7 {ECO:0000303|PubMed:21644208};
DE Flags: Precursor;
GN Name=NLP7 {ECO:0000303|PubMed:24886309};
GN Synonyms=NPP7 {ECO:0000303|PubMed:21644208};
OS Phytophthora capsici.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4784;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DOMAIN.
RX PubMed=21644208; DOI=10.4238/vol10-2gmr1248;
RA Feng B.Z., Li P.Q., Fu L., Sun B.B., Zhang X.G.;
RT "Identification of 18 genes encoding necrosis-inducing proteins from the
RT plant pathogen Phytophthora capsici (Pythiaceae: Oomycetes).";
RL Genet. Mol. Res. 10:910-922(2011).
RN [2]
RP INDUCTION, AND FUNCTION.
RX PubMed=24886309; DOI=10.1186/1471-2229-14-126;
RA Feng B.Z., Zhu X.P., Fu L., Lv R.F., Storey D., Tooley P., Zhang X.G.;
RT "Characterization of necrosis-inducing NLP proteins in Phytophthora
RT capsici.";
RL BMC Plant Biol. 14:126-126(2014).
CC -!- FUNCTION: Secreted effector that contributes moderately to virulence
CC during infection by P.capsici. Does not cause visible reaction of
CC C.annuum for several days after inoculation, but by 7 days after
CC inoculation, small necrotic lesions become visible. Leads only to
CC chlorotic areas, without necrosis at 7 days after non-host
CC N.benthamiana leaves infection. {ECO:0000269|PubMed:24886309}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21644208}.
CC -!- INDUCTION: Expression gradually increases to a maximum at 7 days after
CC inoculation of pepper leaves. {ECO:0000269|PubMed:24886309}.
CC -!- DOMAIN: The structure of NLP effectors is remarkably conserved with a
CC high level of conservation of a central hepta-peptide motif GHRHDWE.
CC {ECO:0000305|PubMed:21644208}.
CC -!- SIMILARITY: Belongs to the Necrosis inducing protein (NPP1) family.
CC {ECO:0000305}.
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DR EMBL; HM543173; AEJ88238.1; -; Genomic_DNA.
DR AlphaFoldDB; L7NCQ5; -.
DR SMR; L7NCQ5; -.
DR VEuPathDB; FungiDB:DVH05_022932; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR008701; NPP1.
DR PANTHER; PTHR33657; PTHR33657; 1.
DR Pfam; PF05630; NPP1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Secreted; Signal; Virulence.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..318
FT /note="NLP effector protein 7"
FT /id="PRO_5003982419"
FT REGION 23..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 202..208
FT /note="Hepta-peptide GHRHDWE motif"
FT /evidence="ECO:0000305|PubMed:24886309"
FT COMPBIAS 23..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..96
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 318 AA; 35051 MW; DAD68F37D03DED4D CRC64;
MRLFAFLWSS VAFLSTVQAQ VSQTASQTQD DSSTPTPTPT DKYVNIADAL RTKTPMATPN
RTIMPTRQDP RATEPPTPEP TYLPTPSPTP APTPDPGPWV AKWMDHDQVQ PFKQPDPVTV
SEKAAVKFKP QIHITNGCHP YPAVTWWGET SGGLKTKGAP SAGCKGSGWG SQVYGRSTWV
KGVWAIMYSW YFPKDSPSTG LGHRHDWEHV IVWIDNPDIE NPKILAVTPS AHSGYSKQVP
PSADCVDGTS VKVKYESKWP INHALESTTE GGETQDLIMW NQLSENALRA MNSVTWGDAN
CPFCDGNFQA KLDKAWPF
