NLP9_PHYCP
ID NLP9_PHYCP Reviewed; 318 AA.
AC L7NCR7;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 1.
DT 03-AUG-2022, entry version 17.
DE RecName: Full=NLP effector protein 9 {ECO:0000303|PubMed:24886309};
DE AltName: Full=Necrosis-inducing protein 9 {ECO:0000303|PubMed:21644208};
DE AltName: Full=Nep1-like protein 9 {ECO:0000303|PubMed:21644208};
DE Flags: Precursor;
GN Name=NLP9 {ECO:0000303|PubMed:24886309};
GN Synonyms=NPP9 {ECO:0000303|PubMed:21644208};
OS Phytophthora capsici.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4784;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DOMAIN.
RX PubMed=21644208; DOI=10.4238/vol10-2gmr1248;
RA Feng B.Z., Li P.Q., Fu L., Sun B.B., Zhang X.G.;
RT "Identification of 18 genes encoding necrosis-inducing proteins from the
RT plant pathogen Phytophthora capsici (Pythiaceae: Oomycetes).";
RL Genet. Mol. Res. 10:910-922(2011).
RN [2]
RP INDUCTION, AND FUNCTION.
RX PubMed=24886309; DOI=10.1186/1471-2229-14-126;
RA Feng B.Z., Zhu X.P., Fu L., Lv R.F., Storey D., Tooley P., Zhang X.G.;
RT "Characterization of necrosis-inducing NLP proteins in Phytophthora
RT capsici.";
RL BMC Plant Biol. 14:126-126(2014).
CC -!- FUNCTION: Secreted effector that contributes to virulence during
CC infection by P.capsici. Induces distinct chlorosis at 3 days after
CC inoculation of host C.annuum leaves, and all the chlorotic areas
CC gradually turn brown and become moderately necrotic at 7 days after
CC inoculation. Caused only small necrotic areas at 7 days after non-host
CC N.benthamiana leaves infection. {ECO:0000269|PubMed:24886309}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21644208}.
CC -!- INDUCTION: Expression reached the highest levels at 3 days after
CC inoculation of pepper leaves, followed by a gradual decline.
CC {ECO:0000269|PubMed:24886309}.
CC -!- DOMAIN: The structure of NLP effectors is remarkably conserved with a
CC high level of conservation of a central hepta-peptide motif GHRHDWE.
CC {ECO:0000305|PubMed:21644208}.
CC -!- SIMILARITY: Belongs to the Necrosis inducing protein (NPP1) family.
CC {ECO:0000305}.
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DR EMBL; HM543175; AEJ88240.1; -; Genomic_DNA.
DR AlphaFoldDB; L7NCR7; -.
DR SMR; L7NCR7; -.
DR VEuPathDB; FungiDB:DVH05_022932; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR008701; NPP1.
DR PANTHER; PTHR33657; PTHR33657; 1.
DR Pfam; PF05630; NPP1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Secreted; Signal; Virulence.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..318
FT /note="NLP effector protein 9"
FT /id="PRO_5003982506"
FT REGION 24..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 202..208
FT /note="Hepta-peptide GHRHDWE motif"
FT /evidence="ECO:0000305|PubMed:24886309"
FT COMPBIAS 24..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..93
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 318 AA; 35059 MW; AC41E1C130C4D373 CRC64;
MRLFAFLWSS VAFLSTVQAQ VSQTASQTQD DSSTPTPTPP DKYVNIADAL RTKTPMATPN
RTIMPTRQDP RAPEPPTPEP TYLPTLSPTP APTPDPGPWV AKWMDHDQVQ PFKQPDPVTV
SEKAAVKFKP QIHITNGCHP YPAVTWWGET SGGLKTKGAP SAGCKGSGWG SQVYGRSTWV
KGVWAIMYSW YFPKDSPSTG LGHRHDWEHV IVWIDNPDIE NPKILAVTPS AHSGYSKQVP
PSADCVDGTS VKVKYESKWP INHALESTTE GGETQDLIMW NQLSENALRA MNSVTWGDAN
CPFCDGNFQA KLDKAWPF
