ID   NLPA_ECO57              Reviewed;         272 AA.
AC   Q8XC50;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Lipoprotein 28;
DE   Flags: Precursor;
GN   Name=nlpA; OrderedLocusNames=Z5147, ECs4595;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the NlpA lipoprotein family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG58856.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38018.1; -; Genomic_DNA.
DR   PIR; C91203; C91203.
DR   PIR; D86049; D86049.
DR   RefSeq; NP_312622.1; NC_002695.1.
DR   RefSeq; WP_000779412.1; NZ_SEKU01000014.1.
DR   AlphaFoldDB; Q8XC50; -.
DR   SMR; Q8XC50; -.
DR   STRING; 155864.EDL933_4981; -.
DR   EnsemblBacteria; AAG58856; AAG58856; Z5147.
DR   EnsemblBacteria; BAB38018; BAB38018; ECs_4595.
DR   GeneID; 915435; -.
DR   KEGG; ece:Z5147; -.
DR   KEGG; ecs:ECs_4595; -.
DR   PATRIC; fig|386585.9.peg.4802; -.
DR   eggNOG; COG1464; Bacteria.
DR   HOGENOM; CLU_067080_0_0_6; -.
DR   OMA; QDNKAHN; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004872; Lipoprotein_NlpA.
DR   PANTHER; PTHR30429; PTHR30429; 1.
DR   Pfam; PF03180; Lipoprotein_9; 1.
DR   PIRSF; PIRSF002854; MetQ; 1.
DR   TIGRFAMs; TIGR00363; TIGR00363; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           24..272
FT                   /note="Lipoprotein 28"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT                   /id="PRO_0000019738"
FT   LIPID           24
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           24
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   272 AA;  29423 MW;  A52B4C8576E443F5 CRC64;
     MKLTTHHLRA GAALLLAGVL LAGCDQSSSD EKHIKVGVIN GAEQDVAEVA KKVAKEKYGL
     DVELVGFSGS LLPNDATNNG ELDANVFQHR PFLEQDNQTH GYKLVAVGNT FVFPMAGYSK
     KIKTVAQIKE GATVAIPNDP TNLGRALLLL QKEKLITLKE GKGLLPTALD ITDNPRHLQI
     MELEGAQLPR VLDDPKVDVA IISTTYIEQT GLSPVNDSVF IEDKNSPYVN ILVAREDNKN
     AENVKEFLQS YQSPEVAKAA ETIFNGGAVP GW