NLPC_HAEIN
ID NLPC_HAEIN Reviewed; 183 AA.
AC P45296;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Probable endopeptidase NlpC homolog;
DE EC=3.4.-.-;
DE AltName: Full=Probable lipoprotein NlpC homolog;
DE Flags: Precursor;
GN Name=nlpC; OrderedLocusNames=HI_1652;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the peptidase C40 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01284, ECO:0000305}.
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DR EMBL; L42023; AAC23297.1; -; Genomic_DNA.
DR PIR; H64173; H64173.
DR RefSeq; NP_439794.1; NC_000907.1.
DR RefSeq; WP_005659678.1; NC_000907.1.
DR AlphaFoldDB; P45296; -.
DR SMR; P45296; -.
DR STRING; 71421.HI_1652; -.
DR MEROPS; C40.004; -.
DR DNASU; 950494; -.
DR EnsemblBacteria; AAC23297; AAC23297; HI_1652.
DR KEGG; hin:HI_1652; -.
DR PATRIC; fig|71421.8.peg.1729; -.
DR eggNOG; COG0791; Bacteria.
DR HOGENOM; CLU_016043_9_1_6; -.
DR OMA; GQYGFDC; -.
DR PhylomeDB; P45296; -.
DR BioCyc; HINF71421:G1GJ1-1669-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR Pfam; PF00877; NLPC_P60; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS51935; NLPC_P60; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Lipoprotein; Membrane; Palmitate; Protease;
KW Reference proteome; Signal; Thiol protease.
FT SIGNAL 1..17
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 18..183
FT /note="Probable endopeptidase NlpC homolog"
FT /id="PRO_0000019755"
FT DOMAIN 65..183
FT /note="NlpC/P60"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 95
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 143
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 155
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT LIPID 18
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 18
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 183 AA; 20586 MW; 772BE57F79452E38 CRC64;
MLKRILVIIG LAVLATACSN APRTVSHQVI SENDDIQLTG LINNLEKDNR TGIFHKVRTN
RSSALMGDKA LASVYNEWVG TRYRMGGTTK RGIDCSAFMQ TTFSEVFGIE LPRSTAEQRH
LGRKINKSEL KKGDLVFFRK NNHVGVYIGN NQFMHASTGQ GVTISSLDEK YWARTYTQSR
RIM
