ID   NLPD_SALDU              Reviewed;         377 AA.
AC   P39700;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Murein hydrolase activator NlpD;
DE   Flags: Precursor;
GN   Name=nlpD;
OS   Salmonella dublin.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=98360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=Lane;
RX   PubMed=9973354; DOI=10.1128/jb.181.4.1264-1268.1999;
RA   Paesold G., Krause M.;
RT   "Analysis of rpoS mRNA in Salmonella dublin: identification of multiple
RT   transcripts with growth-phase dependent variation in transcript
RT   stability.";
RL   J. Bacteriol. 181:1264-1268(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 284-377.
RC   STRAIN=Lane;
RA   Krause M.W., El-Gedaily A.;
RL   Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activator of the cell wall hydrolase AmiC. Required for
CC       septal murein cleavage and daughter cell separation during cell
CC       division (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=Localizes at the septal
CC       ring. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the E.coli NlpD/Haemophilus LppB family.
CC       {ECO:0000305}.
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DR   EMBL; AJ006131; CAA06881.1; -; Genomic_DNA.
DR   EMBL; X82129; CAA57639.1; -; Genomic_DNA.
DR   PIR; S49470; S49470.
DR   RefSeq; WP_001272631.1; NZ_VDCP01000001.1.
DR   AlphaFoldDB; P39700; -.
DR   SMR; P39700; -.
DR   PATRIC; fig|98360.39.peg.2646; -.
DR   OMA; TMFLIAY; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   CDD; cd00118; LysM; 1.
DR   Gene3D; 2.70.70.10; -; 1.
DR   Gene3D; 3.10.350.10; -; 1.
DR   InterPro; IPR011055; Dup_hybrid_motif.
DR   InterPro; IPR018392; LysM_dom.
DR   InterPro; IPR036779; LysM_dom_sf.
DR   InterPro; IPR016047; Peptidase_M23.
DR   Pfam; PF01476; LysM; 1.
DR   Pfam; PF01551; Peptidase_M23; 1.
DR   SMART; SM00257; LysM; 1.
DR   SUPFAM; SSF51261; SSF51261; 1.
DR   PROSITE; PS51782; LYSM; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Lipoprotein;
KW   Membrane; Palmitate; Repeat; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..377
FT                   /note="Murein hydrolase activator NlpD"
FT                   /id="PRO_0000018030"
FT   DOMAIN          119..163
FT                   /note="LysM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT   REPEAT          203..209
FT                   /note="1"
FT   REPEAT          225..231
FT                   /note="2"
FT   REPEAT          237..243
FT                   /note="3"
FT   REPEAT          244..250
FT                   /note="4"
FT   REGION          30..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..250
FT                   /note="4 X 7 AA approximate repeats"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   377 AA;  39671 MW;  DC7F59B943F86512 CRC64;
     MSAGSPKFTV SRIAALSLVS LWLAGCTSSS NPPAPVTSVD SGSSSNTNSG MLITPPPKMG
     ATTQQTPQQA PQIQPVQRPV TQPMQTQPVT EQPVQMENGR IVYNRQYGNI PKGSYTGGST
     YTVKKGDTLF YIAWITGNDF RDLAQRNSIS APYSLNVGQT LQVGNASGMP ITGGNAITQA
     DAAQQGVVTR SAQNSTVAVA SQPTITYSEG SGEQSANKML PNNKPAGTVV TAPVTAPTVS
     TTEPNASSTS TSAPISAWRW PTDGKVIENF GASEGGNKGI DIAGSKGQAI VATADGRVVY
     AGNALRGYGN LIIIKHNDDY LSAYAHNDTM LVREQQEVKA GQKIATMGST GTSSTRLHFE
     IRYKGKSVNP LRYLPQR