NLPD_SALTI
ID NLPD_SALTI Reviewed; 373 AA.
AC Q56131;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2001, sequence version 2.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=Murein hydrolase activator NlpD;
DE Flags: Precursor;
GN Name=nlpD; OrderedLocusNames=STY3050, t2826;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 255-373.
RC STRAIN=Ty21a;
RX PubMed=7705608; DOI=10.1111/j.1574-6968.1995.tb07412.x;
RA Robbe-Saule V., Coynault C., Norel F.;
RT "The live oral typhoid vaccine Ty21a is a rpoS mutant and is susceptible to
RT various environmental stresses.";
RL FEMS Microbiol. Lett. 126:171-176(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 269-373.
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=9919662; DOI=10.1111/j.1574-6968.1999.tb13366.x;
RA Robbe-Saule V., Norel F.;
RT "The rpoS mutant allele of Salmonella typhi Ty2 is identical to that of the
RT live typhoid vaccine Ty21a.";
RL FEMS Microbiol. Lett. 170:141-143(1999).
CC -!- FUNCTION: Activator of the cell wall hydrolase AmiC. Required for
CC septal murein cleavage and daughter cell separation during cell
CC division (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=Localizes at the septal
CC ring. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the E.coli NlpD/Haemophilus LppB family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL513382; CAD06031.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70383.1; -; Genomic_DNA.
DR EMBL; X81641; CAA57297.1; -; Genomic_DNA.
DR EMBL; Y17610; CAA76806.1; -; Genomic_DNA.
DR RefSeq; NP_457314.1; NC_003198.1.
DR RefSeq; WP_001272624.1; NZ_WSUR01000005.1.
DR AlphaFoldDB; Q56131; -.
DR SMR; Q56131; -.
DR STRING; 220341.16503998; -.
DR EnsemblBacteria; AAO70383; AAO70383; t2826.
DR KEGG; stt:t2826; -.
DR KEGG; sty:STY3050; -.
DR PATRIC; fig|220341.7.peg.3102; -.
DR eggNOG; COG1388; Bacteria.
DR eggNOG; COG4942; Bacteria.
DR HOGENOM; CLU_029425_0_1_6; -.
DR OMA; TMFLIAY; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 2.70.70.10; -; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR016047; Peptidase_M23.
DR Pfam; PF01476; LysM; 1.
DR Pfam; PF01551; Peptidase_M23; 1.
DR SMART; SM00257; LysM; 1.
DR SUPFAM; SSF51261; SSF51261; 1.
DR PROSITE; PS51782; LYSM; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Lipoprotein;
KW Membrane; Palmitate; Repeat; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 26..373
FT /note="Murein hydrolase activator NlpD"
FT /id="PRO_0000018031"
FT DOMAIN 115..159
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT REPEAT 199..205
FT /note="1"
FT REPEAT 221..227
FT /note="2"
FT REPEAT 233..239
FT /note="3"
FT REPEAT 240..246
FT /note="4"
FT REGION 30..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..246
FT /note="4 X 7 AA approximate repeats"
FT COMPBIAS 30..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 26
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 26
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 373 AA; 39183 MW; DD075BB440098FF7 CRC64;
MSAGSPKFTV SRIAALSLVS LWLAGCTSSS NPPAPVTSVD SGSSSNTNSG MLITPPPKMG
ATPQQAPQIQ PVQRPVTQPM QTQPVTEQPV QMENGRIVYN RQYGNIPKGS YTGGSTYTVK
KGDTLFYIAW ITGNDFRDLA QRNSISAPYS LNVGQTLQVG NASGTPITGG NAITQADAAQ
QGVVTRSAQN STVAVASQPT ITYSEGSGEQ SANKMLPNNK PAGTVVTAPV TAPTVSTTEP
NASSTSTSAP ISAWRWPTDG KVIENFGASE GGNKGIDIAG SKGQAIVATA DGRVVYAGNA
LRGYGNLIII KHNDDYLSAY AHNDTMLVRE QQEVKAGQKI ATMGSTGTSS TRLHFEIRYK
GKSVNPLRYL PQR
