ID   NLPI_HAEIN              Reviewed;         314 AA.
AC   P44585;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Lipoprotein NlpI homolog;
DE   Flags: Precursor;
GN   Name=nlpI; OrderedLocusNames=HI_0230;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: May be involved in cell division. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
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DR   EMBL; L42023; AAC21899.1; -; Genomic_DNA.
DR   PIR; G64145; G64145.
DR   RefSeq; NP_438402.1; NC_000907.1.
DR   RefSeq; WP_005694062.1; NC_000907.1.
DR   AlphaFoldDB; P44585; -.
DR   SMR; P44585; -.
DR   STRING; 71421.HI_0230; -.
DR   EnsemblBacteria; AAC21899; AAC21899; HI_0230.
DR   KEGG; hin:HI_0230; -.
DR   PATRIC; fig|71421.8.peg.244; -.
DR   eggNOG; COG4785; Bacteria.
DR   HOGENOM; CLU_071600_0_0_6; -.
DR   OMA; VEHRYSF; -.
DR   PhylomeDB; P44585; -.
DR   BioCyc; HINF71421:G1GJ1-247-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR023605; Lipoprotein_NlpI.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PIRSF; PIRSF004654; NlpI; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Repeat; Signal; TPR repeat.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..314
FT                   /note="Lipoprotein NlpI homolog"
FT                   /id="PRO_0000035693"
FT   REPEAT          74..107
FT                   /note="TPR 1"
FT   REPEAT          108..141
FT                   /note="TPR 2"
FT   REPEAT          246..279
FT                   /note="TPR 3"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   314 AA;  36434 MW;  0E87CAE286CC5722 CRC64;
     MRCFRLSRHF IVYLFSLCAI LLLAGCVQSR GGFVSKNHVV LAEQNPNTHF EQEVMIVRLS
     QVLLVGKMSN EERASLHFER GVLYDSLGLW GLARYDLTQA LALQPKMASV YNYLGLYLLL
     EEDYDGALDA FNTVFELDSG YDYTHLNRGL NFYYVGRYHL AQQDFLQFYQ ADKKDPYRVL
     WLYLNEQKLK PQEAQTNLVE RAKGLSEDFW GTHIVQYYLG HISVEELQQR ASEFAENSQQ
     YAEILTETYF YLAKQKLNVG LVDEAAALFK LAMANQVYNF VEYRFAAFEL MKLKPVQTED
     EKEEKSAVTK AIVF