NLR9A_MOUSE
ID NLR9A_MOUSE Reviewed; 949 AA.
AC Q66X03; Q6UQE7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 9A;
DE AltName: Full=NALP-theta;
GN Name=Nlrp9a; Synonyms=Nalp9a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA Dudekula D.B., VanBuren V., Ko M.S.H.;
RT "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL Hum. Mol. Genet. 13:2263-2278(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RA Martinon F., Hofmann K., Tschopp J.;
RT "Murine NALPs: a family of proteins involved in inflammation.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 322-331, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- FUNCTION: May be involved in inflammation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q66X22}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q66X03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q66X03-2; Sequence=VSP_025022, VSP_025023;
CC -!- TISSUE SPECIFICITY: Oocyte specific. {ECO:0000269|PubMed:15317747}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
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DR EMBL; AY596202; AAU06323.1; -; mRNA.
DR EMBL; AY364009; AAQ63459.1; -; mRNA.
DR CCDS; CCDS39845.1; -. [Q66X03-1]
DR RefSeq; NP_001041684.1; NM_001048219.2.
DR RefSeq; NP_001041685.1; NM_001048220.2.
DR AlphaFoldDB; Q66X03; -.
DR SMR; Q66X03; -.
DR STRING; 10090.ENSMUSP00000104024; -.
DR PRIDE; Q66X03; -.
DR ProteomicsDB; 253079; -. [Q66X03-1]
DR ProteomicsDB; 253080; -. [Q66X03-2]
DR DNASU; 233001; -.
DR GeneID; 233001; -.
DR KEGG; mmu:233001; -.
DR UCSC; uc012fge.1; mouse. [Q66X03-2]
DR CTD; 233001; -.
DR MGI; MGI:2675292; Nlrp9a.
DR eggNOG; KOG4308; Eukaryota.
DR InParanoid; Q66X03; -.
DR OrthoDB; 114368at2759; -.
DR BioGRID-ORCS; 233001; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q66X03; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q66X03; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061702; C:inflammasome complex; ISO:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0001824; P:blastocyst development; IGI:MGI.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Cytoplasm; Direct protein sequencing;
KW Immunity; Inflammatory response; Innate immunity; Leucine-rich repeat;
KW Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..949
FT /note="NACHT, LRR and PYD domains-containing protein 9A"
FT /id="PRO_0000286335"
FT DOMAIN 1..94
FT /note="Pyrin"
FT DOMAIN 143..465
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 695..716
FT /note="LRR 1"
FT REPEAT 724..745
FT /note="LRR 2"
FT REPEAT 752..772
FT /note="LRR 3"
FT REPEAT 781..802
FT /note="LRR 4"
FT REPEAT 809..829
FT /note="LRR 5"
FT BINDING 149..156
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT VAR_SEQ 788..844
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_025022"
FT VAR_SEQ 944..949
FT /note="VWNSKN -> KLLEVERAGIGFPGTVVTGNNELPGMKSLPPESTRSTGGTVT
FT SLV (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_025023"
FT CONFLICT 181
FT /note="H -> Y (in Ref. 2; AAQ63459)"
FT /evidence="ECO:0000305"
FT CONFLICT 616
FT /note="G -> D (in Ref. 2; AAQ63459)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 949 AA; 109680 MW; 6CFA098FB8DE22FA CRC64;
MMDSSGYGLL QYLQKLSDEE FQRFKEHLRK EPEKFKLKPI SWTKIKNTSK EDLVMQLYTH
YPGKAWDMVL SLFLQVNRED LSTMAQTERR DKQTKYKEFM KNTFQHIWTM ETNTYIPDRS
YHEFIEVQYR ALQDIFDCES EPVTVVVSGS RGGGKTTFLR KAMLDWASRN LLQNRFQYVF
HFSVFSLNNI TELSLAELIS STLPESSETV DDILSDPKRI LFILDGFDYL KFDLELRTNL
CNDWRKKLPI QIVLSSLLQK IMLPECSLLL ELGNASLSNI IPLLQYPREI IMSGFSEQTI
EIYCVSFFNT QTGVEIFKNL KSIKPLFNLC RCPHLCWMIC STIKWQYERR EVASRFGRTL
GLLYTIFMVS AFKSTYARNP SKQNRARIRT LCTLAVEGMW KQVYVFDSDD LRRNGISESD
KKVWLRMKFL QNQGSNIVFY HSTLQWYFAV LFYFLQYKDT RHPVIGNLAQ LLGEIYAHKQ
NQWFHTRILL FGMATEQVNS LLEPCFGCIS SKEVRQEIIR YIKSLSQQEC NEKLVVHPQN
LFFCILDNQE ERFVRQLMDR FEEMTVDISD VDDMSATPYC LHRAPKVKNL HLHIQKRVFL
EIHDPEYGDL ELFKLGQKCS FTTNFGDGLL FCTFLHLPHL KYMNLYGTNL SNDAVERLCS
ALKFSTCGVE ELLLGKCDIS SEACGIIAAS LINSEVKHLS LVENPLKNKG VMSLCEMLKD
PSCVLESLML SYCCLTFIAC GHLYEALLSN EHLSLLDLGS NFLEDTGVNL LCEALKDPNC
TLKELWLPGC YLTSECCEEI SAVLTCNTNL KTLKLGNNNI QDTGVKRLCE ALCHPNCEMQ
CLGLDMCDFT SDCCEDLALV LTTCNTLKSL NLDWNAFDHS GLEMLCKALN HKACNLEVLG
LDKSLFSEES QTLLQAVEKK NKNLKVLHFP WLKEELEKRG VRLVWNSKN
