NLR9C_MOUSE
ID NLR9C_MOUSE Reviewed; 1004 AA.
AC Q66X01; Q3ULL8; Q6UTW8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 9C;
DE AltName: Full=NALP-zeta;
GN Name=Nlrp9c; Synonyms=Nalp9c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA Dudekula D.B., VanBuren V., Ko M.S.H.;
RT "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL Hum. Mol. Genet. 13:2263-2278(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RA Martinon F., Hofmann K., Tschopp J.;
RT "Murine NALPs: a family of proteins involved in inflammation.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 129-1004 (ISOFORM 1).
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in inflammation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q66X22}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q66X01-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q66X01-2; Sequence=VSP_025027, VSP_025028, VSP_025029;
CC -!- TISSUE SPECIFICITY: Oocyte specific. {ECO:0000269|PubMed:15317747}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
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DR EMBL; AY596203; AAU06324.1; -; mRNA.
DR EMBL; AY360472; AAQ64010.1; -; mRNA.
DR EMBL; AK145425; BAE26430.1; -; mRNA.
DR CCDS; CCDS39843.1; -. [Q66X01-1]
DR RefSeq; NP_001036077.1; NM_001042612.1. [Q66X01-1]
DR AlphaFoldDB; Q66X01; -.
DR SMR; Q66X01; -.
DR STRING; 10090.ENSMUSP00000083106; -.
DR PaxDb; Q66X01; -.
DR PRIDE; Q66X01; -.
DR ProteomicsDB; 253081; -. [Q66X01-1]
DR ProteomicsDB; 253082; -. [Q66X01-2]
DR DNASU; 330490; -.
DR Ensembl; ENSMUST00000041845; ENSMUSP00000036041; ENSMUSG00000040614. [Q66X01-2]
DR Ensembl; ENSMUST00000085944; ENSMUSP00000083106; ENSMUSG00000040614. [Q66X01-1]
DR GeneID; 330490; -.
DR KEGG; mmu:330490; -.
DR UCSC; uc009fuj.1; mouse. [Q66X01-1]
DR UCSC; uc012fgb.2; mouse. [Q66X01-2]
DR CTD; 330490; -.
DR MGI; MGI:3028627; Nlrp9c.
DR VEuPathDB; HostDB:ENSMUSG00000040614; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000163218; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; Q66X01; -.
DR OMA; MKWWLER; -.
DR OrthoDB; 114368at2759; -.
DR PhylomeDB; Q66X01; -.
DR BioGRID-ORCS; 330490; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q66X01; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q66X01; protein.
DR Bgee; ENSMUSG00000040614; Expressed in animal zygote and 8 other tissues.
DR Genevisible; Q66X01; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061702; C:inflammasome complex; ISO:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0001824; P:blastocyst development; IGI:MGI.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Cytoplasm; Immunity;
KW Inflammatory response; Innate immunity; Leucine-rich repeat;
KW Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..1004
FT /note="NACHT, LRR and PYD domains-containing protein 9C"
FT /id="PRO_0000286337"
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT DOMAIN 143..465
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 750..770
FT /note="LRR 1"
FT REPEAT 779..800
FT /note="LRR 2"
FT REPEAT 807..828
FT /note="LRR 3"
FT REPEAT 836..857
FT /note="LRR 4"
FT REPEAT 864..884
FT /note="LRR 5"
FT BINDING 149..156
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT VAR_SEQ 619..673
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_025027"
FT VAR_SEQ 843..899
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_025028"
FT VAR_SEQ 956..1004
FT /note="LDKSSFSEESQTFLQAVEKKNNNLNVLHFPWVEDELKKRGVRLVWNSKN ->
FT QVTFIRTRINAVRLLVLRQQYHALKDQDPVIEE (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_025029"
FT CONFLICT 479
FT /note="H -> Y (in Ref. 3; BAE26430)"
FT /evidence="ECO:0000305"
FT CONFLICT 968
FT /note="F -> S (in Ref. 3; BAE26430)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1004 AA; 115722 MW; 99ACBCE759C85F75 CRC64;
MVDSSSYGLL QYFQKLSDEE FQRFKELLQK EQEKFKLKPL SWTKIKNTSK EDLVTQLYTH
YPRQVWDMVL NLFLQVNRKD LSTMAQIERR DKQNKYKEFM KNLFQYIWTS ETNTYMPDRS
YNTIIDRQYK ALLDIFDSES DPATAVVLGT RGKGKTVFLR KAMLDWASGV LLQNRFQYVF
FFSVFSLNNT TELSLAELIS SKLPECSETL DDILSNPKRI LFVLDGFDYL KFDLELRTNL
CNDWRKRLPT QNVLSSLLQK IMLPECSLLL ELGESSCSKI IPLLQNPREI IMSGLSEQSI
YFYCVSFFKI QLGVEVFKDL KKNEPLFTLC SNPSMLWMIC SSLMWGHYSR EEVISSSEST
SAIHTIFIMS AFKSIFGLGS SKYKRFKLKT LCTLAVEGMW KQVYVFDSED LRRNKISESD
KTVWLKMKFL QIQGNNIMFY HSTLQWYFAT LFYFLKQDKD TYHPVIGSLP QLLGEIYAHK
QNQWTHAQTF FFGIATKHVI TLLKPCFGNI SFKTIRQEII RYLKSLSQPE CNEKLVHPKK
LFFCLIENQE ERFVSQVMNL FEEITVDISD SDDLGAAEYS LLRASKLKNL HLHIQKKVFS
EIHDPEYGSL ENFKLDQKFS AINWTMLSIL FCNLHVLDLG SCHFNKKVIE VLCNSLSPTP
NMPLTVFKLQ RLLCSFMTNF GDGSLFCTFL QIPQLKYLNL YGTDLSNDVV EMLCSALKCS
TCRVEELLLG KCDISSEACG IMATFLINSK VKHLSLVENP LKNKGVMFLC KMLKDPSCVL
ESLMLSYCCL TFIACGHLYE ALLSNKHLSL LDLGSNFLED IGVNLLCEAL KYPNCTLKEL
WLPGCYLTSE CCEEISAVLT CNKNLKTLKL GNNNIQDTGV KRLCEALCHP KCKVQCLGLD
MCELSNDCCE DLALALITCN TLKSLNLDWN ALHHSGLVML CEALNHKKCK LNMLGLDKSS
FSEESQTFLQ AVEKKNNNLN VLHFPWVEDE LKKRGVRLVW NSKN
