NLRC5_HUMAN
ID NLRC5_HUMAN Reviewed; 1866 AA.
AC Q86WI3; B5MEF1; C9JMD8; Q6P4A6; Q86VM7; Q8NF42; Q8TEE2; Q8TEJ1; Q969L7;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Protein NLRC5;
DE AltName: Full=Caterpiller protein 16.1;
DE Short=CLR16.1;
DE AltName: Full=Nucleotide-binding oligomerization domain protein 27;
DE AltName: Full=Nucleotide-binding oligomerization domain protein 4;
GN Name=NLRC5; Synonyms=NOD27, NOD4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-907.
RX PubMed=12615073; DOI=10.1016/s0006-291x(03)00221-3;
RA Dowds T.A., Masumoto J., Chen F.F., Ogura Y., Inohara N., Nunez G.;
RT "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial
RT Mediterranean fever gene product.";
RL Biochem. Biophys. Res. Commun. 302:575-580(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ASP-907.
RA Kronos K.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 850-1866 (ISOFORM 6), AND VARIANTS ASP-907 AND
RP LYS-1105.
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 274-1866 (ISOFORM 2), AND
RP VARIANTS LEU-453 AND ARG-500.
RC TISSUE=Spleen;
RX PubMed=12693554; DOI=10.1093/dnares/10.1.49;
RA Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N.,
RA Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen. II. The
RT complete sequences of 81 cDNA clones.";
RL DNA Res. 10:49-57(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 971-1385 (ISOFORM 5), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1030-1866, AND VARIANT LYS-1105.
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1067-1866 (ISOFORM 4).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP CHUK; DDX58; IFIH1 AND IKBKB.
RX PubMed=20434986; DOI=10.1016/j.cell.2010.03.040;
RA Cui J., Zhu L., Xia X., Wang H.Y., Legras X., Hong J., Ji J., Shen P.,
RA Zheng S., Chen Z.J., Wang R.F.;
RT "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling
RT pathways.";
RL Cell 141:483-496(2010).
RN [9]
RP FUNCTION, INDUCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=20061403; DOI=10.4049/jimmunol.0900557;
RA Kuenzel S., Till A., Winkler M., Hasler R., Lipinski S., Jung S.,
RA Grotzinger J., Fickenscher H., Schreiber S., Rosenstiel P.;
RT "The nucleotide-binding oligomerization domain-like receptor NLRC5 is
RT involved in IFN-dependent antiviral immune responses.";
RL J. Immunol. 184:1990-2000(2010).
RN [10]
RP REVIEW.
RX PubMed=15771576; DOI=10.1146/annurev.immunol.23.021704.115616;
RA Ting J.P.-Y., Davis B.K.;
RT "CATERPILLER: a novel gene family important in immunity, cell death, and
RT diseases.";
RL Annu. Rev. Immunol. 23:387-414(2005).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] ILE-361.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Probable regulator of the NF-kappa-B and type I interferon
CC signaling pathways. May also regulate the type II interferon signaling
CC pathway. Plays a role in homeostatic control of innate immunity and in
CC antiviral defense mechanisms. {ECO:0000269|PubMed:20061403,
CC ECO:0000269|PubMed:20434986}.
CC -!- SUBUNIT: Interacts with CHUK and IKBKB; prevents CHUK and IKBKB
CC phosphorylation and inhibits their kinase activity. Interacts with
CC DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.
CC {ECO:0000269|PubMed:20434986}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20061403,
CC ECO:0000269|PubMed:20434986}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q86WI3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86WI3-2; Sequence=VSP_027152, VSP_027153;
CC Name=3;
CC IsoId=Q86WI3-3; Sequence=VSP_027150;
CC Name=4;
CC IsoId=Q86WI3-4; Sequence=VSP_027151;
CC Name=5;
CC IsoId=Q86WI3-5; Sequence=VSP_027151, VSP_027154, VSP_027155;
CC Name=6;
CC IsoId=Q86WI3-6; Sequence=VSP_027156, VSP_027157;
CC -!- TISSUE SPECIFICITY: Expressed in spleen, thymus, lung, brain, tonsil,
CC heart and prostate. {ECO:0000269|PubMed:20061403,
CC ECO:0000269|PubMed:20434986}.
CC -!- INDUCTION: By IFNG/IFN-gamma. {ECO:0000269|PubMed:20061403}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 6]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
CC -!- CAUTION: Supposed to contain a CARD domain at the N-terminus
CC (PubMed:20434986). However, this domain is not detected by Pfam,
CC PROSITE or SMART. Has a weak similarity with a DAPIN domain.
CC {ECO:0000305|PubMed:20434986}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB55096.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB55098.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB85008.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF389420; AAO59377.1; -; mRNA.
DR EMBL; EF452236; ABO40479.1; -; mRNA.
DR EMBL; AK074133; BAB84959.1; -; mRNA.
DR EMBL; AK074182; BAB85008.1; ALT_INIT; mRNA.
DR EMBL; AC009090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC023825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK090439; BAC03420.1; -; mRNA.
DR EMBL; BC050527; AAH50527.1; -; mRNA.
DR EMBL; BC063566; AAH63566.1; -; mRNA.
DR EMBL; AK027414; BAB55096.1; ALT_INIT; mRNA.
DR EMBL; AK027416; BAB55098.1; ALT_INIT; mRNA.
DR CCDS; CCDS10773.1; -. [Q86WI3-1]
DR CCDS; CCDS81985.1; -. [Q86WI3-4]
DR RefSeq; NP_001317481.1; NM_001330552.1. [Q86WI3-4]
DR RefSeq; NP_115582.4; NM_032206.4. [Q86WI3-1]
DR RefSeq; XP_005256250.1; XM_005256193.2.
DR RefSeq; XP_005256251.1; XM_005256194.3. [Q86WI3-1]
DR RefSeq; XP_005256254.1; XM_005256197.2.
DR RefSeq; XP_006721360.1; XM_006721297.2.
DR RefSeq; XP_011521675.1; XM_011523373.2. [Q86WI3-1]
DR AlphaFoldDB; Q86WI3; -.
DR BioGRID; 123922; 13.
DR IntAct; Q86WI3; 5.
DR MINT; Q86WI3; -.
DR STRING; 9606.ENSP00000262510; -.
DR iPTMnet; Q86WI3; -.
DR PhosphoSitePlus; Q86WI3; -.
DR BioMuta; NLRC5; -.
DR DMDM; 269849666; -.
DR EPD; Q86WI3; -.
DR jPOST; Q86WI3; -.
DR MassIVE; Q86WI3; -.
DR MaxQB; Q86WI3; -.
DR PaxDb; Q86WI3; -.
DR PeptideAtlas; Q86WI3; -.
DR PRIDE; Q86WI3; -.
DR ProteomicsDB; 70166; -. [Q86WI3-1]
DR ProteomicsDB; 70167; -. [Q86WI3-2]
DR ProteomicsDB; 70168; -. [Q86WI3-3]
DR ProteomicsDB; 70169; -. [Q86WI3-4]
DR ProteomicsDB; 70170; -. [Q86WI3-5]
DR ProteomicsDB; 70171; -. [Q86WI3-6]
DR Antibodypedia; 44042; 92 antibodies from 26 providers.
DR DNASU; 84166; -.
DR Ensembl; ENST00000262510.10; ENSP00000262510.6; ENSG00000140853.17. [Q86WI3-1]
DR Ensembl; ENST00000539144.5; ENSP00000441727.1; ENSG00000140853.17. [Q86WI3-4]
DR Ensembl; ENST00000539881.5; ENSP00000441679.1; ENSG00000140853.17. [Q86WI3-3]
DR Ensembl; ENST00000688547.1; ENSP00000509992.1; ENSG00000140853.17. [Q86WI3-1]
DR GeneID; 84166; -.
DR KEGG; hsa:84166; -.
DR MANE-Select; ENST00000688547.1; ENSP00000509992.1; NM_001384950.1; NP_001371879.1.
DR UCSC; uc010ccq.2; human. [Q86WI3-1]
DR CTD; 84166; -.
DR DisGeNET; 84166; -.
DR GeneCards; NLRC5; -.
DR HGNC; HGNC:29933; NLRC5.
DR HPA; ENSG00000140853; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 613537; gene.
DR neXtProt; NX_Q86WI3; -.
DR OpenTargets; ENSG00000140853; -.
DR PharmGKB; PA162397694; -.
DR VEuPathDB; HostDB:ENSG00000140853; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000160652; -.
DR HOGENOM; CLU_383986_0_0_1; -.
DR InParanoid; Q86WI3; -.
DR OMA; AAMVHMW; -.
DR PhylomeDB; Q86WI3; -.
DR PathwayCommons; Q86WI3; -.
DR Reactome; R-HSA-168928; DDX58/IFIH1-mediated induction of interferon-alpha/beta.
DR Reactome; R-HSA-936440; Negative regulators of DDX58/IFIH1 signaling.
DR SignaLink; Q86WI3; -.
DR BioGRID-ORCS; 84166; 13 hits in 1071 CRISPR screens.
DR ChiTaRS; NLRC5; human.
DR GeneWiki; NLRC5; -.
DR GenomeRNAi; 84166; -.
DR Pharos; Q86WI3; Tbio.
DR PRO; PR:Q86WI3; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q86WI3; protein.
DR Bgee; ENSG00000140853; Expressed in granulocyte and 147 other tissues.
DR ExpressionAtlas; Q86WI3; baseline and differential.
DR Genevisible; Q86WI3; HS.
DR GO; GO:0005813; C:centrosome; IDA:HPA.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:BHF-UCL.
DR GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
DR GO; GO:0051607; P:defense response to virus; IEP:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IMP:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IDA:UniProtKB.
DR GO; GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IDA:UniProtKB.
DR GO; GO:0045345; P:positive regulation of MHC class I biosynthetic process; IDA:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR GO; GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IDA:UniProtKB.
DR GO; GO:0043549; P:regulation of kinase activity; IDA:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 6.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041210; NLRC5_atypical_Card.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF18461; Atypical_Card; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR SMART; SM00367; LRR_CC; 9.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51450; LRR; 13.
DR PROSITE; PS50837; NACHT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Cytoplasm; Immunity; Innate immunity;
KW Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..1866
FT /note="Protein NLRC5"
FT /id="PRO_0000296189"
FT DOMAIN 222..539
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 599..622
FT /note="LRR 1"
FT REPEAT 713..737
FT /note="LRR 2"
FT REPEAT 741..765
FT /note="LRR 3"
FT REPEAT 769..792
FT /note="LRR 4"
FT REPEAT 869..892
FT /note="LRR 5"
FT REPEAT 897..921
FT /note="LRR 6"
FT REPEAT 930..953
FT /note="LRR 7"
FT REPEAT 976..1000
FT /note="LRR 8"
FT REPEAT 1004..1026
FT /note="LRR 9"
FT REPEAT 1031..1058
FT /note="LRR 10"
FT REPEAT 1138..1161
FT /note="LRR 11"
FT REPEAT 1162..1184
FT /note="LRR 12"
FT REPEAT 1242..1265
FT /note="LRR 13"
FT REPEAT 1272..1294
FT /note="LRR 14"
FT REPEAT 1462..1488
FT /note="LRR 15"
FT REPEAT 1493..1516
FT /note="LRR 16"
FT REPEAT 1521..1544
FT /note="LRR 17"
FT REPEAT 1554..1577
FT /note="LRR 18"
FT REPEAT 1578..1600
FT /note="LRR 19"
FT REPEAT 1605..1628
FT /note="LRR 20"
FT REPEAT 1633..1656
FT /note="LRR 21"
FT REPEAT 1661..1684
FT /note="LRR 22"
FT REPEAT 1687..1714
FT /note="LRR 23"
FT REPEAT 1715..1739
FT /note="LRR 24"
FT REPEAT 1741..1762
FT /note="LRR 25"
FT REPEAT 1795..1818
FT /note="LRR 26"
FT REGION 105..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 228..235
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT VAR_SEQ 721..1866
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_027150"
FT VAR_SEQ 1221..1249
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_027151"
FT VAR_SEQ 1307..1328
FT /note="NLGSEQSFRIHFSREDQAGKTL -> KCLGSWHVWAPCFPRPFSLQPGL
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693554"
FT /id="VSP_027152"
FT VAR_SEQ 1329..1866
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693554"
FT /id="VSP_027153"
FT VAR_SEQ 1385
FT /note="R -> S (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027154"
FT VAR_SEQ 1386..1866
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027155"
FT VAR_SEQ 1501..1551
FT /note="LTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWM
FT -> IQSSQDPGRLLPDLLPFDPHQADLQLCEHRGPRPPGIWSGPLPPLGGAGLV (in
FT isoform 6)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_027156"
FT VAR_SEQ 1552..1866
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_027157"
FT VARIANT 210
FT /note="S -> L (in dbSNP:rs16965150)"
FT /id="VAR_034607"
FT VARIANT 361
FT /note="M -> I (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036388"
FT VARIANT 453
FT /note="P -> L (in dbSNP:rs9938543)"
FT /evidence="ECO:0000269|PubMed:12693554"
FT /id="VAR_034608"
FT VARIANT 500
FT /note="C -> R (in dbSNP:rs28438857)"
FT /evidence="ECO:0000269|PubMed:12693554"
FT /id="VAR_034609"
FT VARIANT 833
FT /note="S -> N (in dbSNP:rs35534915)"
FT /id="VAR_034610"
FT VARIANT 907
FT /note="N -> D (in dbSNP:rs1672867)"
FT /evidence="ECO:0000269|PubMed:12615073, ECO:0000269|Ref.2,
FT ECO:0000269|Ref.3"
FT /id="VAR_060589"
FT VARIANT 1105
FT /note="Q -> K (in dbSNP:rs289723)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_034611"
FT VARIANT 1455
FT /note="V -> A (in dbSNP:rs7190199)"
FT /id="VAR_034612"
FT VARIANT 1466
FT /note="Q -> R (in dbSNP:rs7185320)"
FT /id="VAR_034613"
FT CONFLICT 808..810
FT /note="ADL -> RTI (in Ref. 1; AAO59377 and 2; ABO40479)"
FT /evidence="ECO:0000305"
FT CONFLICT 1411
FT /note="T -> A (in Ref. 7; BAB55096/BAB55098)"
FT /evidence="ECO:0000305"
FT CONFLICT 1715
FT /note="S -> F (in Ref. 7; BAB55096/BAB55098)"
FT /evidence="ECO:0000305"
FT CONFLICT 1794
FT /note="Q -> K (in Ref. 1; AAO59377, 2; ABO40479 and 6;
FT AAH63566)"
FT /evidence="ECO:0000305"
FT CONFLICT 1803
FT /note="L -> P (in Ref. 7; BAB55096/BAB55098)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1866 AA; 204595 MW; 4E3BDED8E1624967 CRC64;
MDPVGLQLGN KNLWSCLVRL LTKDPEWLNA KMKFFLPNTD LDSRNETLDP EQRVILQLNK
LHVQGSDTWQ SFIHCVCMQL EVPLDLEVLL LSTFGYDDGF TSQLGAEGKS QPESQLHHGL
KRPHQSCGSS PRRKQCKKQQ LELAKKYLQL LRTSAQQRYR SQIPGSGQPH AFHQVYVPPI
LRRATASLDT PEGAIMGDVK VEDGADVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR
LCQKWAEGHL NCFQALFLFE FRQLNLITRF LTPSELLFDL YLSPESDHDT VFQYLEKNAD
QVLLIFDGLD EALQPMGPDG PGPVLTLFSH LCNGTLLPGC RVMATSRPGK LPACLPAEAA
MVHMLGFDGP RVEEYVNHFF SAQPSREGAL VELQTNGRLR SLCAVPALCQ VACLCLHHLL
PDHAPGQSVA LLPNMTQLYM QMVLALSPPG HLPTSSLLDL GEVALRGLET GKVIFYAKDI
APPLIAFGAT HSLLTSFCVC TGPGHQQTGY AFTHLSLQEF LAALHLMASP KVNKDTLTQY
VTLHSRWVQR TKARLGLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGA KQAAVVQVLK
KLATRKLTGP KVVELCHCVD ETQEPELASL TAQSLPYQLP FHNFPLTCTD LATLTNILEH
REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD AFAEALSRSL PTMGRLQMLG
LAGSKITARG ISHLVKALPL CPQLKEVSFR DNQLSDQVVL NIVEVLPHLP RLRKLDLSSN
SICVSTLLCL ARVAVTCPTV RMLQAREADL IFLLSPPTET TAELQRAPDL QESDGQRKGA
QSRSLTLRLQ KCQLQVHDAE ALIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIA
RKLDLSNNGL SVAGVHCVLR AVSACWTLAE LHISLQHKTV IFMFAQEPEE QKGPQERAAF
LDSLMLQMPS ELPLSSRRMR LTHCGLQEKH LEQLCKALGG SCHLGHLHLD FSGNALGDEG
AARLAQLLPG LGALQSLNLS ENGLSLDAVL GLVRCFSTLQ WLFRLDISFE SQHILLRGDK
TSRDMWATGS LPDFPAAAKF LGFRQRCIPR SLCLSECPLE PPSLTRLCAT LKDCPGPLEL
QLSCEFLSDQ SLETLLDCLP QLPQLSLLQL SQTGLSPKSP FLLANTLSLC PRVKKVDLRS
LHHATLHFRS NEEEEGVCCG RFTGCSLSQE HVESLCWLLS KCKDLSQVDL SANLLGDSGL
RCLLECLPQV PISGLLDLSH NSISQESALY LLETLPSCPR VREASVNLGS EQSFRIHFSR
EDQAGKTLRL SECSFRPEHV SRLATGLSKS LQLTELTLTQ CCLGQKQLAI LLSLVGRPAG
LFSLRVQEPW ADRARVLSLL EVCAQASGSV TEISISETQQ QLCVQLEFPR QEENPEAVAL
RLAHCDLGAH HSLLVGQLME TCARLQQLSL SQVNLCEDDD ASSLLLQSLL LSLSELKTFR
LTSSCVSTEG LAHLASGLGH CHHLEELDLS NNQFDEEGTK ALMRALEGKW MLKRLDLSHL
LLNSSTLALL THRLSQMTCL QSLRLNRNSI GDVGCCHLSE ALRAATSLEE LDLSHNQIGD
AGVQHLATIL PGLPELRKID LSGNSISSAG GVQLAESLVL CRRLEELMLG CNALGDPTAL
GLAQELPQHL RVLHLPFSHL GPGGALSLAQ ALDGSPHLEE ISLAENNLAG GVLRFCMELP
LLRQIDLVSC KIDNQTAKLL TSSFTSCPAL EVILLSWNLL GDEAAAELAQ VLPQMGRLKR
VDLEKNQITA LGAWLLAEGL AQGSSIQVIR LWNNPIPCDM AQHLKSQEPR LDFAFFDNQP
QAPWGT
