ID   NLRC5_ICTPU             Reviewed;        1726 AA.
AC   C6FG12;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Protein NLRC5;
GN   Name=nlrc5;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=19414032; DOI=10.1016/j.dci.2009.04.004;
RA   Sha Z., Abernathy J.W., Wang S., Li P., Kucuktas H., Liu H., Peatman E.,
RA   Liu Z.;
RT   "NOD-like subfamily of the nucleotide-binding domain and leucine-rich
RT   repeat containing family receptors and their expression in channel
RT   catfish.";
RL   Dev. Comp. Immunol. 33:991-999(2009).
CC   -!- FUNCTION: Probable regulator of the NF-kappa-B and type I interferon
CC       signaling pathways. May also regulate the type II interferon signaling
CC       pathway. Plays a role in homeostatic control of innate immunity and in
CC       antiviral defense mechanisms (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
CC   -!- CAUTION: Supposed to contain a CARD domain at the N-terminus. However,
CC       this domain is not detected by Pfam, PROSITE or SMART. Has a weak
CC       similarity with a DAPIN domain. {ECO:0000305}.
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DR   EMBL; FJ004847; ACM45227.1; -; mRNA.
DR   RefSeq; NP_001186995.1; NM_001200066.1.
DR   AlphaFoldDB; C6FG12; -.
DR   SMR; C6FG12; -.
DR   STRING; 7998.ENSIPUP00000029542; -.
DR   GeneID; 100303710; -.
DR   KEGG; ipu:100303710; -.
DR   CTD; 84166; -.
DR   OrthoDB; 19417at2759; -.
DR   Proteomes; UP000221080; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 8.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13516; LRR_6; 4.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   SMART; SM00367; LRR_CC; 6.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Immunity; Innate immunity; Leucine-rich repeat;
KW   Nucleotide-binding; Repeat.
FT   CHAIN           1..1726
FT                   /note="Protein NLRC5"
FT                   /id="PRO_0000397876"
FT   DOMAIN          207..537
FT                   /note="NACHT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT   REPEAT          879..902
FT                   /note="LRR 1"
FT   REPEAT          904..925
FT                   /note="LRR 2"
FT   REPEAT          1002..1025
FT                   /note="LRR 3"
FT   REPEAT          1026..1048
FT                   /note="LRR 4"
FT   REPEAT          1103..1126
FT                   /note="LRR 5"
FT   REPEAT          1128..1155
FT                   /note="LRR 6"
FT   REPEAT          1212..1235
FT                   /note="LRR 7"
FT   REPEAT          1351..1374
FT                   /note="LRR 8"
FT   REPEAT          1387..1411
FT                   /note="LRR 9"
FT   REPEAT          1421..1443
FT                   /note="LRR 10"
FT   REPEAT          1447..1468
FT                   /note="LRR 11"
FT   REPEAT          1502..1525
FT                   /note="LRR 12"
FT   REPEAT          1532..1553
FT                   /note="LRR 13"
FT   REPEAT          1560..1580
FT                   /note="LRR 14"
FT   REPEAT          1588..1609
FT                   /note="LRR 15"
FT   REPEAT          1616..1637
FT                   /note="LRR 16"
FT   REPEAT          1642..1662
FT                   /note="LRR 17"
FT   REPEAT          1670..1691
FT                   /note="LRR 18"
FT   BINDING         213..220
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
SQ   SEQUENCE   1726 AA;  192891 MW;  56AC36A437CDDD8B CRC64;
     MKMEEMDLEE DVLDVVDQEA STIVDILCEQ RDNVLQRIFA LVDARTREQL QHLPNNRESI
     SGLVDYFRTS DQHTCRRFLD IIWSFCENIP LELDIRIVNL AGSTAGALVN NSHVPDTENS
     PQSRYGKRAR LDQVQSYTNA VKSFLQKKFE KVTKDIKKEV CLNNTWLCWR TQKYARVRDR
     PAKSQEGEEV SLEHKESVEA LLMKTGRVVM LSGQAGSGKT LLMHCLAHHW AQGSYPSIEL
     LFLLEFRQLN LISQPLSLKE LLFRFFLPSD EDDEQSEAVL NYVLSNPEKI CFIFDGYDEF
     GARFKDPKEL ECSVNPYQQL PLADLLSALC SAKILPGCTV LVTCRPRDVF DLFGSSDYFV
     AELLGFNQQR VKEYTQEYFQ EKGCEIKERA VSLLMDSHHL LSMSHVPGLC HVCCVCLDHF
     LTSDMSQQPG TQLPTSLTQI YLHILSAFIS RCHGCGSSDN HTPLLQRYRV QIAMLSKLAM
     DGLENSRIVF PANELTTELM NFGANAGILS RLDLTCGDGS RRLGCAFTHL TIQEFMAALH
     LMTNPDITES QLKKKLNLKS RWTAKTDPKT VFTDSLHLYM CGLAAEACTS NLVLLKGSEN
     ARAIVLKRQD AVLKTLQRFV VSGRQTGPKI IELCRCAHET QNIDLARAIG PRDRFELRNI
     RLNPVDIDAL AFVISSANQM VCLDFGACYI EPECLNIIPN CKNLEELNFR SRKYDDKFAE
     ALSGILPKLQ SLKQLHFISG GLTNIGAAKL FKASECCPQI TRLNVSDNYL TDESVKKITE
     LFPKLAKLTS VILGKNNISI NGIFILAGKM AAFPNIKEVY ANAKKKEINV QFSANTTNSA
     STDDLNNTEE SKQLILNDWN LKWTNVHNLC PMLRGCSSLT VLNLSHNALG NRGLKKLLEH
     LPTLDTIQEI NVSDNGVDMD GVVLLSPLLC TLKDLTEVEA SHNGKKMLVL TFSSSIIDAL
     KQVTSEGCDI LHKKLSLTHS DIHPTDMNKL CKNLIKCPNP LNLDFSHGTL KDESTEKLLK
     FLPNMASLNL LNLSHIQMST DSALLLVQLL SDCQRTTTVE LRQLGETFIK FLQDKSEAAT
     CKFNQYRLSS ANLAKLCEIL EHCHHLTDLD LSSNFLKDED VKTFVQFLPK LQISGSVSLN
     NNNLTEVGVL YLLSLMHTCE RVAAVEVSLG KEEQQDIIGF VQKNCTGKTF RLSSCTVQSQ
     NVLFLLNKLA TLNSVQTLEL RNNSFSADTI KYLITEFCGD CNHRTIRIME PWIKGEAAVG
     LVQCCLELNP NIKEIRVEKT CLKLSVESLV SATIPNEWEN GNCSLSAVHC ISFDDCEVEG
     QHLSSLQSAL RNCPSLQELH FSQLTMGADG AEFLSSVLPS LKNLKILSLS SKGETEDEAV
     IFALQHAQKH LEQLSLAHHV IKDRGAAVLG NALQGFTRMR SLSLLKCLDW TATGGRDLVR
     GLVQCHSLEE IRLDSIELDE ESIDCFAQGL QAMTSLKKIS LNKTISKEGS GVLCLLASLH
     PLIELEEIEL IGLRMGDRGV EELVKHIPKW TRLRKINLSE NRVSDHAGEM LVKALSHCRA
     LQQIHLFRNN LGHSSAAVLG QVLPSLSELT ELDLSENQME SKGCSSVCEA LVSMKALKKL
     HLTSIGTSDL VNVASCLKHC TSIEDISLSW NNCENDVVLK LAEVLPQCSK LKRLDLEANN
     INTSGAMALA TCLQFCPWIE VIRLWRNPIK KDDLILKDKR LNFSST