NLR_MEGGA
ID NLR_MEGGA Reviewed; 130 AA.
AC O50258;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Neelaredoxin;
DE EC=1.15.1.1;
DE AltName: Full=Superoxide dismutase;
GN Name=nlr;
OS Megalodesulfovibrio gigas (Desulfovibrio gigas).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC Desulfovibrionaceae; Megalodesulfovibrio.
OX NCBI_TaxID=879;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Shenvi N.V., Kurtz D.M. Jr.;
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759;
RX PubMed=9914498; DOI=10.1046/j.1432-1327.1999.00025.x;
RA Silva G., Oliveira S., Gomes C.M., Pacheco I., Liu M.Y., Xavier A.V.,
RA Teixeira M., LeGall J., Rodrigues-Pousada C.;
RT "Desulfovibrio gigas neelaredoxin. A novel superoxide dismutase integrated
RT in a putative oxygen sensory operon of an anaerobe.";
RL Eur. J. Biochem. 259:235-243(1999).
RN [3]
RP PROTEIN SEQUENCE OF 1-28.
RC STRAIN=ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759;
RX PubMed=8001576; DOI=10.1111/j.1432-1033.1994.tb20087.x;
RA Chen L., Sharma P., le Gall J., Mariano A.M., Teixeira M., Xavier A.V.;
RT "A blue non-heme iron protein from Desulfovibrio gigas.";
RL Eur. J. Biochem. 226:613-618(1994).
CC -!- FUNCTION: Non-heme iron protein.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Note=Binds 2 iron ions per subunit.;
CC -!- SUBUNIT: Monomer.
CC -!- MISCELLANEOUS: Has a reduction potential of +190 mV.
CC -!- SIMILARITY: Belongs to the desulfoferrodoxin family. {ECO:0000305}.
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DR EMBL; AF034965; AAB87989.1; -; Genomic_DNA.
DR EMBL; AF096317; AAD13200.1; -; Genomic_DNA.
DR AlphaFoldDB; O50258; -.
DR SMR; O50258; -.
DR OMA; HHIAWIE; -.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.40.730; -; 1.
DR InterPro; IPR002742; Desulfoferrodoxin_Fe-bd_dom.
DR InterPro; IPR036073; Desulfoferrodoxin_Fe-bd_dom_sf.
DR Pfam; PF01880; Desulfoferrodox; 1.
DR SUPFAM; SSF49367; SSF49367; 1.
DR TIGRFAMs; TIGR00332; neela_ferrous; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Electron transport; Iron; Metal-binding;
KW Oxidoreductase; Transport.
FT CHAIN 1..130
FT /note="Neelaredoxin"
FT /id="PRO_0000140869"
FT BINDING 15
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 17
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 45
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 51
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 115
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 118
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT CONFLICT 4
FT /note="C -> Y (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 14523 MW; F0B8E1262CDA4180 CRC64;
MKMCDMFQTA DWKTEKHVPA IECDDAVAAD AFFPVTVSLG KEIAHPNTTE HHIRWIRCYF
KPEGDKFSYE VGSFEFTAHG ECAKGPNEGP VYTNHTVTFQ LKIKTPGVLV ASSFCNIHGL
WESSKAVALK
