ID   NLSA_EMENI              Reviewed;        6077 AA.
AC   Q5BDY8; C8VSP8;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   23-FEB-2022, entry version 113.
DE   RecName: Full=Nonribosomal peptide synthase nlsA {ECO:0000303|PubMed:23248299};
DE            EC=6.3.2.- {ECO:0000305|PubMed:23248299};
DE   AltName: Full=Nidulanin A synthase {ECO:0000305};
GN   Name=nlsA {ECO:0000303|PubMed:23248299}; ORFNames=ANIA_01242;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND PATHWAY.
RX   PubMed=23248299; DOI=10.1073/pnas.1205532110;
RA   Andersen M.R., Nielsen J.B., Klitgaard A., Petersen L.M., Zachariasen M.,
RA   Hansen T.J., Blicher L.H., Gotfredsen C.H., Larsen T.O., Nielsen K.F.,
RA   Mortensen U.H.;
RT   "Accurate prediction of secondary metabolite gene clusters in filamentous
RT   fungi.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:E99-E107(2013).
CC   -!- FUNCTION: Nonribosomal peptide synthase involved in the synthesis of
CC       nidulanin A and derived compounds (PubMed:23248299). Nidulanin A is a
CC       tetracyclopeptide with the sequence L-Phe-L-Kyn-L-Val-D-Val and an
CC       isoprene unit N-linked to the amino group of L-kynurenine
CC       (PubMed:23248299). The NRPS nlsA is responsible of the synthesis of the
CC       cyclopeptide and the prenyltransferase nptA adds the isoprene unit on
CC       the L-kynurenine residue of nidulanin A (PubMed:23248299). Further
CC       modifications lead to additional oxygenated related compounds
CC       (PubMed:23248299). {ECO:0000269|PubMed:23248299}.
CC   -!- PATHWAY: Secondary metabolite biosynthesis.
CC       {ECO:0000269|PubMed:23248299}.
CC   -!- DOMAIN: NRP synthetases are composed of discrete domains (adenylation
CC       (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation
CC       (C) domains) which when grouped together are referred to as a single
CC       module (By similarity). Each module is responsible for the recognition
CC       (via the A domain) and incorporation of a single amino acid into the
CC       growing peptide product (By similarity). Thus, an NRP synthetase is
CC       generally composed of one or more modules and can terminate in a
CC       thioesterase domain (TE) that releases the newly synthesized peptide
CC       from the enzyme (By similarity). Occasionally, methyltransferase
CC       domains (responsible for amino acid methylation) are present within the
CC       NRP synthetase (By similarity). {ECO:0000250|UniProtKB:A0A144KPJ6}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the biosynthesis of nidulanin A and
CC       related compounds (PubMed:23248299). {ECO:0000269|PubMed:23248299}.
CC   -!- SIMILARITY: Belongs to the NRP synthetase family. {ECO:0000305}.
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DR   EMBL; BN001308; CBF87869.1; -; Genomic_DNA.
DR   RefSeq; XP_658846.1; XM_653754.1.
DR   SMR; Q5BDY8; -.
DR   STRING; 162425.CADANIAP00001381; -.
DR   EnsemblFungi; CBF87869; CBF87869; ANIA_01242.
DR   EnsemblFungi; EAA65835; EAA65835; AN1242.2.
DR   GeneID; 2877020; -.
DR   KEGG; ani:AN1242.2; -.
DR   eggNOG; KOG1178; Eukaryota.
DR   HOGENOM; CLU_000022_60_6_1; -.
DR   InParanoid; Q5BDY8; -.
DR   OMA; DIVSWRI; -.
DR   OrthoDB; 4243at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000036; F:acyl carrier activity; IBA:GO_Central.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IBA:GO_Central.
DR   Gene3D; 1.10.1200.10; -; 5.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 3.30.559.10; -; 6.
DR   Gene3D; 3.40.50.12780; -; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF00668; Condensation; 8.
DR   Pfam; PF00550; PP-binding; 4.
DR   SUPFAM; SSF47336; SSF47336; 5.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 5.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Isomerase; Ligase; Multifunctional enzyme; Phosphopantetheine;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..6077
FT                   /note="Nonribosomal peptide synthase nlsA"
FT                   /id="PRO_0000444198"
FT   DOMAIN          751..827
FT                   /note="Carrier 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          3297..3373
FT                   /note="Carrier 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          4361..4437
FT                   /note="Carrier 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          5334..5410
FT                   /note="Carrier 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   DOMAIN          5921..6004
FT                   /note="Carrier 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   REGION          417..618
FT                   /note="Adenylation 1"
FT                   /evidence="ECO:0000255"
FT   REGION          842..1267
FT                   /note="Condensation 1"
FT                   /evidence="ECO:0000255"
FT   REGION          1309..1737
FT                   /note="Condensation 2"
FT                   /evidence="ECO:0000255"
FT   REGION          1757..2149
FT                   /note="Adenylation 2"
FT                   /evidence="ECO:0000255"
FT   REGION          2755..3157
FT                   /note="Adenylation 3"
FT                   /evidence="ECO:0000255"
FT   REGION          3524..3779
FT                   /note="Condensation 3"
FT                   /evidence="ECO:0000255"
FT   REGION          3816..4213
FT                   /note="Adenylation 4"
FT                   /evidence="ECO:0000255"
FT   REGION          4451..4869
FT                   /note="Condensation 4"
FT                   /evidence="ECO:0000255"
FT   REGION          4916..5260
FT                   /note="Condensation 5"
FT                   /evidence="ECO:0000255"
FT   REGION          5476..5885
FT                   /note="Condensation 6"
FT                   /evidence="ECO:0000255"
FT   REGION          6013..6047
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6029..6045
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         788
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         3334
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         4398
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         5371
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   6077 AA;  677235 MW;  3397E5B0A5E5A7E0 CRC64;
     MAQQAQCLLP SFGTISDGPK RPVSITTKTT PSQSAKLLSA YKNDSLDPLL KTAWGLLLYR
     YTGLQDVCFG YKHDDAGALV SQTSDAGRLL TFRLTINEHD TIKTILEKSG GGYGCQTDIG
     VSGSSNANND NYSSFNTVVM VRVCGDSTKE ETFVRPVFQS ILPEECRARL HVKVLQEDIC
     IFLEWWNTDI STAQMESVAR YFEHILNQVL YSDDTVVANA DCFLEQDWAR ICKFNSVIPE
     TYDRCIHDVI SEQVRLHPQR EAVCAWDGSF TYGELDVLAS ELSYRLKGYG VRPETFVALC
     FDKSKWNIVA MLGVLKAGGA FVPLDPTHPT PRLRSLVDSV NVNIMLCSRN RAEHLSKVVN
     NLIPLDEQSF GKISFPPRGY LRQEVKSNNA AYLIFTSGST GKPKGTLLEH RAFVSCVFAY
     APLIHGGCVC VPSEEERLND IVQAINRMNV NFICLTPSFA RFVNPSSIPQ VNTALLVGEA
     MSRTDLEAWS HIKLLNGYGP TEAAVCAAIN STMDINSDCR DIGLATGTHF WVVKPNNHDQ
     LVPVGCPGEL LLEGPTLARC YINNPEKTDE VFIYNPTWAR HDPKRGDRRF YKTGDLVRYN
     SDLGSLTFLG RKDSQIKLHG QRIELGEIEH NISTLPLVKH GMAFLCESGP AKGRLMAVVS
     LNGELSSNTV PFKLLPPAER TYAVTELRQQ LSKRLPTYMI PAVWLCVEAL PLLPSGKLNR
     REIISWATNK TDDFQGGASE SSGVETPKAA HSEVTVEDRL KSIWSRVLAI PRDRISLDES
     FLALGGDSIA AITCMGYCKK QGMGVTVQDV LQSKSIRDLV TRVQEIKHLV KYQEETEEPF
     GLSPIQKLHF MIRKEGQGYF NQSVRTRLSR RLSADDLRHA IQVIIERHSM LRVRLIKDTL
     VGNLRQRITR DIDSSYRLRV HNINHQAQME SAISVSQSCI NAFQGPIMAV DIFYTEDDCF
     LSMVAHHLAI DIVSWRIILE DLEDILLRSE DKTIYTSSLP FSTWCHLQDE RTQTFGSYLE
     DLPIPDAAYW GVENRVATYG DAICETFELG LDDSKSILME CHKSLATEPV DILLASLLHA
     FGQTFRDRSL PAIYNEGHGR EAWDSSIDIS RTVGWFTTVF PIFIREQIPD DPVETVVLVK
     DIRRSVSDNG RQRFASLMSA STKDEKREFL CPMEISFNYV GQHRDLQRQD GLFQLMNQMA
     GETGQGGGAS DFGKETPRFG LFEISALAVN GRLRFIFSFS KYMRHQKRIR AWIASCGDVL
     RSLGKRLQTH AKRPTLSDFP MLSLTYPDIE SMLAKTLPSL GVSSPELIED IYPCSRMQQG
     ILLARSRDSS LYAVHDTYEV RGFNGKPDVA RLAEAWRMVV SRHAMLRTLF VENLTSRDLF
     SQLVLRNCEP SILYLSCPTD DDVVSTFNSQ RPEIYNEYQP HHRLTFCETA SGRVFFRLEL
     SHAAMDGVSI SVILRDLQLA YDGKLDQNKP LFKNYIQYLR NTPQDASIVY WKNYLADVKP
     CLFPTLTDGK IIAQKQLKVL RPKFNLFNDL QTACEERRLT LSSAFTAAWG LTLSLFCGSN
     DVCFSYMTSL RDALVDDIES VVGPVINLLA CRVKISEGDT LRDIMQKVQN DCMEQLAYNT
     LSLIDIVHEL RLSEQALINT GISYQRVTKM QMHHTTGINL SRVCAIQDPA EYPLFVNVVA
     SDKAAEIEVN YWTDTLSDEQ AESVSSTFFK CLENIVRHLK EQVGQLEVLS DWNKQRIRKW
     NKQLPEEVDM LVQDIIQEKM ASQPDKPAII AWDGTLTYAE LEYLSSCFAA YLQQLGVRRG
     TLMPIYVGKS VWQIVAILAV FKTGAICVPR DEAQLGDSVD KWLVDHGAHI VVTLPSLAGS
     LERQFPVVVP INKSLFEFLP SSSQENLPQV YPHDDSFIAF DSSDPHESSA VLDQRAIIAR
     AASFASTINS NSGTKTFQYA PCTSDMFLQE VMGTFMSGGC LCIPRSDSLS QLSRSINETS
     ANLICLTPLV ASFIRPSDVP SIQVLVLFGE QSARNVRNIW SEKVQLYTFY GRTECSSTCI
     QVSGLDDLDT QSSIGTSVGC CSWVVDPQDF TRLVPVGCIG ELVIEGPSVS RGYFCHEKQK
     KERFTEQDRG LMEPAKRPYT LFPGSRRKMF RTGYLVRYNA DGTLVYLGEK VDSMDQTLQM
     IAFKIEQLLD VQGSAGYRCV AEILDLRIEE YPEPCIAVFI LSTEKQQSNT IKQSTVIARK
     TNNSHMLMAK LHASLAASLP ASQVPSLYFP VFGLPMTSLG KVNRPLLRKA VKSLSADSLT
     EYDLKKFGEF WRHQLEKPSL SGQHLLQPFP IQESPALKMV DKGELLVNAK ESSNSAEQFL
     PQATMIPRRV QVNNSTSISG LLDQTASCLV KARPYEKTPL SSIRSLNADT SQASDFDSAL
     SISSMTSQQQ SQYLRSLENA ERLHSRFSAC PIVVFCALEE TGVSLEIRYD DRAVYRSQAD
     RLLALFGECL NIFKSTTGLE EKVADLSKRG GNLQIFNDTI DYWKVQLTDI ESCLFPDLSP
     KKGESRLGTE TLRLSNASKM QSACKALSIN PNILLQTVWA LVLRCYTGLE DVCFGYHVST
     KKDSVNILPC RFNLNDDLRL QDVMQKRKED MESASKYQMP LFEILRAIGS ENSPIFNTAF
     RYRKSSSNAA VFNNAVLDPV NEGLNEYLIS VNASVSGSSA EISFDYQSTS LSETDIGHII
     DCFECILNSI LTLLGPSRVI RDVEFFGRQS CQKVSAWNAS LPERPKRCAH TIIQDRVIAQ
     PSAPAICSWD ENFTYSELDS LTTKLAYHLM DWGVGPEVFV GLCFEKSAWA VIAQVAVLKA
     GGAFASLDPA HPESRLRGLV DDIAAPIVLC STRYLDKSSR ICMAALAVSH YTLEQIPDSP
     ATRSLPTLSV ENAAYAIFTS GTTGKPKITV LEHAALDVAS SCFAKTLGID SNTRALQFSS
     YTFDVSILET IITLMTGGCV CTPSDDERMN DLAGAIKRME ANSISCTPSV ISTLDPSSVP
     TLKTIFTGGE KLTEAQIMRW ADRRFYNAYG PSEATIIATA SLKVNRDGIR LDDDCNSIGT
     AVCGRAWIVD PYNHHRLLPV GAVGELVLEG YNIARGYLNN DKKTKEVFIT LPRWLRDSGL
     RDVPKPTGRM YRTGDLVRYK SDKNISFISR MDTQVKLNGQ RIELEEIEQQ CTFISPANTQ
     VAVDIVVPET KTVAKALAAF ITIAGHEAQS ATPGLGVSSS LLLPLSDSIQ RTIGQLHNSL
     GQVLPQVMIP RLYFPVRYLP LGTTGKLDRK GLRAMVQALP KEQLISYMIS NVGSGRAVER
     AAESTLRDLW AKALEIEPGS ISAEDSFFAL GGDSFAAMKL VGAARSQNIS LSFATIYEHP
     VLVDMAKCCD DTEKPAERQR ADLRPFTLVP GSIPLHDIME EVSEQCSVTK DSIADIYPCT
     AVQEGLITLS IKSPGSYVAR IPYRLAASID LQRFKAAWQQ VTDEFDILRT RIVHIENTGF
     LQVVLKKERI SWTLETSLDN VTDDTAEGSG ALLAKYAIVQ LGTDSRYRQC LYKLFIHHLL
     QRDMQQSDEF WKSYLDGLSC EPFPPKKNKD LSCSGAGSIH RASVDISRKV GTTDTTVPEL
     VRSAWAIVLS VHTGSGDVCF GETLMGRNID MPGITDVVGP VLTTVPMRIR VDNKLPINQY
     LRDVRQIITT MIPHQHSGLQ RIQKLSGDAA LACNFQNLLV IQSDDSQLND DIWSPVEQDT
     RGDFFTHPLV VQCQISGPRL LILANYDELV LDDWQTERLI GQFSFVLEQL LSVPRDSLMT
     VGDIDITGPL DKRDIASWNQ RQVTCVNKCV HEIIRENAIM HPQATAICSW DGEITYEEMF
     QLASSFAAYL VICGVGPETL VPVCLGKSLW TMVTVLSVLL AGGAFVPLDP SHPTSRHKEI
     LEEIEADMIL CSPQLRSRYL GSVSTIIPVS EDTIKAYSTV TTSEKANASP TPENMAYAIF
     TSGSTGRPKG IIIEHRAVCS SVIGFAPVVG LNKESRVFQF ASLTFDAAIL EVLGTLMLGG
     CICVPSDDER LNDIPGAMQR MNVSWSFLTP SVACILEPST VPSLQILTCG GEALSSEVVK
     KWTGHVKFYG GYGPTETVVF AVVARDFVDH DFTCIGYGVP STLTWVVQPD DHDRLAPLGA
     VGELVLEGPA LAREYLKNPS KTTDVFINEP AWIKSFPSSL PSPRRIYKTG DLVRYNPDGS
     IEYLGRKDHQ VKLHGQRMEL GEIEHRLLAS ENIRNAVVIL PQKGPLRQKL VAVLSLKSLT
     VESSTIMTGS CELASQKDML ETGYRQIRTS QKSIEEQLPV YMVPQAWAVV KSIPMLVSGK
     LDRKRICTWL EQIDKSAYDR IMQDYDNVDQ VIVEEENKGE REGDATPAII RDIFAQVLNL
     PLNKVDPSRS FIYLGGDSIS GMAVVSKARK RGLNLPLNRI LQAKSIEELA VSCGTKPLPT
     KNVKESGSLF PLSPIQELFF RSASVLPKAL GRFNQSITVR LARRTEPNVL EDAVRAVVQK
     HAMFRARFSK SSDGTWRQRI TDEVDSSYKF CTHPVKNAGN MLSIIADTQS SLDIQRGPVI
     AADLFDKNGE QILFLVASHI CVDVVSWRIV LQELEDFVDT GSIPSDVPLS FKSWCNVQFE
     ESKRLNKSIE IPCQQADLNY WGMSRAPNNY GHVKMDSFAL DKQATAFISG HFHEILGTET
     MEVLLAAVMY SFNRVFPDRD APTIYNEGHG REPWNYSDPS GTIGWFTTLN PLHVEASSDL
     LELLKQVKDT RRRISEHSRA FFAHNVLHSD STDRTHMFSI PLEILFNYLG QLQQLERGGS
     TFQHYGDVFS AETMDSASDM GPETPRFSLF EITALILKEQ LHISFTYNRN MRHQARIQAW
     MAECKRVLEV ELPKFRNVAP QPTLSDYPLL PITYHGLEEL TASVLPRLGL ESWRQVEDIY
     PCSPVQEGIL FSQLRDPHEY IFNAIFELRQ SGNKGSFDLA RLKKAWSTVV VRHPVLRTVF
     IDSCCEEGSF DQVVLKEASD ATVLIECDDL DALNKLEAVS LRSNKSLNLY HQLVLCKTST
     GRVLMKLEMN HVIIDGGSTS ILLRELALAY SNQHPPGPGP LFSEYIKYLR EQPTAEALEY
     WKRRLSDMPP CHLPINASEN GARQLGTHLV AFNRFAALQS FCEANSITFA NLILAVWAIV
     LRSHTKSDDV CFGYPSTGRD LPVPGIQDAV GIFINTLCCR VRFDTNQTLK GTVKSVQEDH
     IASLAYQRSS LAEIQHALGR KGEPLFNTCI SIQNRSEDKT EIAGISYEFQ KAHDPCEMLG
     KGKPVTSWVK SHGAESPSDF PDIRNDVEES LQDLVVMMEK TPASSTQTLN TDYRAPNDSE
     KQLWRLWSIT LGLPPHPVKY HDSFFRLGGD SITAMRLVRA ARDEGLKLSV ADVLKNPVFE
     NMMALINDRK KSIPTTVTEK RADSIEKRVE DKPILTKCES SQDISILRPM SLEFDDTSLR
     AAISPKVGVF KGGIVDVLPV TDFQALSLTA TMFESRWMLN YFYLDGKGSL DIRRLRESFL
     RVVDAFDILR TVFVCFHGQF YQVVLRKIKP DIFVHETEKG LDEYTNSLQQ RDREQSPGQG
     QQCVQFYVVR KTNSDEHRIL VRMSHAQFDG VCLSKIMTAI KMAYEGSPVS PSSFLNYMRL
     LPGNITPEHY QHWGNLLKGS KMTQIVQRDR PNTFQHIGGF TQQSKVIEIP STATENVTIA
     TVMQSAWAVT LAKICAQDDV VFGLTVNGRN AVPGAENTIG PCLNFIPIRV TFKDCWTGLD
     LFRFLQDQQV ANMTYESLGF REIVRRCTDW PESTFFTTSV LHQNVDYEGH MQLDNNTYKM
     GGVGVIDNLT DLTLFSKPVA GQPAQINVAL GYSTKGPIHP SFVSTVLDMV CDTAQSLVAN
     PNVALPSPST IRSLPPQLVE DIPTTGSTDS LLSSLNNHSL SEILVHSDLI TRIWQQVLPP
     KLNTGKPPSS YQLDSSFFGL GGDIVNVAQV VWILEQETGL HIRLEDLLAH STFLGHMAVL
     ALNMTKRDSA GVDSDAAPAP AYAPVDARAS RNVSTSRQQQ EGLPLPAANA KSEWSALDRA
     RVLAKKITRL GGLGTRV