ID   NLT22_PARJU             Reviewed;         133 AA.
AC   O04403;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Probable non-specific lipid-transfer protein 2;
DE            Short=LTP 2;
DE   AltName: Full=Allergen Par j II;
DE   AltName: Full=Major pollen allergen Par j 2.0102;
DE   AltName: Full=Protein P8;
DE   AltName: Allergen=Par j 2.0102;
DE   Flags: Precursor;
OS   Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Urticaceae; Parietaria.
OX   NCBI_TaxID=33127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Flower;
RA   Duro G., Colombo P., Costa M.A., Izzo V., Porcasi R., di Fiore R.,
RA   Locorotondo G., Mirisola M.G., Cocchiara R., Geraci D.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plant non-specific lipid-transfer proteins transfer
CC       phospholipids as well as galactolipids across membranes. May play a
CC       role in wax or cutin deposition in the cell walls of expanding
CC       epidermal cells and certain secretory tissues.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE and
CC       induces histamine release from basophils of Pj-pollen-allergic
CC       subjects.
CC   -!- SIMILARITY: Belongs to the plant LTP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X95866; CAA65122.1; -; mRNA.
DR   AlphaFoldDB; O04403; -.
DR   SMR; O04403; -.
DR   Allergome; 507; Par j 2.
DR   Allergome; 509; Par j 2.0102.
DR   PRIDE; O04403; -.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR000528; Plant_nsLTP.
DR   PANTHER; PTHR33076; PTHR33076; 1.
DR   Pfam; PF14368; LTP_2; 1.
DR   PRINTS; PR00382; LIPIDTRNSFER.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
DR   PROSITE; PS00597; PLANT_LTP; 1.
PE   1: Evidence at protein level;
KW   Allergen; Disulfide bond; Lipid-binding; Signal; Transport.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..133
FT                   /note="Probable non-specific lipid-transfer protein 2"
FT                   /id="PRO_0000018399"
FT   DISULFID        35..83
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..106
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..121
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   133 AA;  14107 MW;  50DFBB1F7806AF85 CRC64;
     MRTVSMAALV VIAAALAWTS SAELASAPAP GEGPCGKVVH HIMPCLKFVK GEEKEPSKSC
     CSGTKKLSEE VKTTEQKREA CKCIVAATKG ISGIKNELVA EVPKKCGITT TLPPITADFD
     CSKIESTIFR GYY