NLTP2_ARATH
ID NLTP2_ARATH Reviewed; 118 AA.
AC Q9S7I3; Q3C1C6; Q41935; Q43277; Q43280;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Non-specific lipid-transfer protein 2;
DE Short=LTP 2;
DE AltName: Full=Protein CELL GROWTH DEFECT FACTOR 3;
DE Flags: Precursor;
GN Name=LTP2; Synonyms=CDF3; OrderedLocusNames=At2g38530; ORFNames=T6A23.27;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Wassilewskija;
RX PubMed=10189704; DOI=10.1093/oxfordjournals.pcp.a029476;
RA Clark A.M., Bohnert H.J.;
RT "Cell-specific expression of genes of the lipid transfer protein family
RT from Arabidopsis thaliana.";
RL Plant Cell Physiol. 40:69-76(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=10940464; DOI=10.1016/s0168-9452(00)00232-6;
RA Arondel V.A., Vergnolle C., Cantrel C., Kader J.-C.;
RT "Lipid transfer proteins are encoded by a small multigene family in
RT Arabidopsis thaliana.";
RL Plant Sci. 157:1-12(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18050905;
RA Kim K.-M., Jun D.-Y., Kim S.-K., Kim C.-K., Kim B.O., Kim Y.-H., Park W.,
RA Sohn J.-K., Hirata A., Kawai-Yamada M., Uchimiya H., Kim D.-H., Sul I.-W.;
RT "Identification of novel mitochondrial membrane protein (Cdf 3) from
RT Arabidopsis thaliana and its functional analysis in a yeast system.";
RL J. Microbiol. Biotechnol. 17:891-896(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-79; 51-118 AND 69-118.
RC STRAIN=cv. Columbia; TISSUE=Green siliques;
RX PubMed=8281187; DOI=10.1046/j.1365-313x.1993.04061051.x;
RA Hoefte H., Desprez T., Amselem J., Chiapello H., Rouze P., Caboche M.,
RA Moisan A., Jourjon M.-F., Charpenteau J.-L., Berthomieu P., Guerrier D.,
RA Giraudat J., Quigley F., Thomas F., Yu D.-Y., Mache R., Raynal M.,
RA Cooke R., Grellet F., Delseny M., Parmentier Y., de Marcillac G., Gigot C.,
RA Fleck J., Philipps G., Axelos M., Bardet C., Tremousaygue D., Lescure B.;
RT "An inventory of 1152 expressed sequence tags obtained by partial
RT sequencing of cDNAs from Arabidopsis thaliana.";
RL Plant J. 4:1051-1061(1993).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18674922; DOI=10.1016/j.plaphy.2008.06.011;
RA Sels J., Mathys J., De Coninck B.M.A., Cammue B.P.A., De Bolle M.F.C.;
RT "Plant pathogenesis-related (PR) proteins: a focus on PR peptides.";
RL Plant Physiol. Biochem. 46:941-950(2008).
CC -!- FUNCTION: Plant non-specific lipid-transfer proteins transfer
CC phospholipids as well as galactolipids across membranes. May play a
CC role in wax or cutin deposition in the cell walls of expanding
CC epidermal cells and certain secretory tissues (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the plant LTP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF057357; AAC24829.1; -; Genomic_DNA.
DR EMBL; AF159799; AAF76928.1; -; mRNA.
DR EMBL; AB238795; BAE46870.1; -; mRNA.
DR EMBL; AC005499; AAC67365.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09546.1; -; Genomic_DNA.
DR EMBL; AY059927; AAL24409.1; -; mRNA.
DR EMBL; AY081562; AAM10124.1; -; mRNA.
DR EMBL; AY085800; AAM63016.1; -; mRNA.
DR EMBL; Z17770; CAA79060.1; -; mRNA.
DR EMBL; Z17787; CAA79068.1; -; mRNA.
DR EMBL; Z18168; CAA79122.1; -; mRNA.
DR PIR; B84806; B84806.
DR RefSeq; NP_181387.1; NM_129410.5.
DR AlphaFoldDB; Q9S7I3; -.
DR SMR; Q9S7I3; -.
DR BioGRID; 3777; 2.
DR STRING; 3702.AT2G38530.1; -.
DR Allergome; 1085; Ara t 3.
DR PaxDb; Q9S7I3; -.
DR PRIDE; Q9S7I3; -.
DR ProteomicsDB; 250537; -.
DR EnsemblPlants; AT2G38530.1; AT2G38530.1; AT2G38530.
DR GeneID; 818435; -.
DR Gramene; AT2G38530.1; AT2G38530.1; AT2G38530.
DR KEGG; ath:AT2G38530; -.
DR Araport; AT2G38530; -.
DR TAIR; locus:2064107; AT2G38530.
DR eggNOG; ENOG502S4CI; Eukaryota.
DR HOGENOM; CLU_128423_0_0_1; -.
DR InParanoid; Q9S7I3; -.
DR OMA; ETLPAKC; -.
DR OrthoDB; 1546493at2759; -.
DR PhylomeDB; Q9S7I3; -.
DR PRO; PR:Q9S7I3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9S7I3; baseline and differential.
DR Genevisible; Q9S7I3; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0005768; C:endosome; HDA:TAIR.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0009505; C:plant-type cell wall; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0005802; C:trans-Golgi network; HDA:TAIR.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0042335; P:cuticle development; IMP:TAIR.
DR GO; GO:0006649; P:phospholipid transfer to membrane; NAS:TAIR.
DR GO; GO:0090627; P:plant epidermal cell differentiation; IMP:TAIR.
DR GO; GO:1901957; P:regulation of cutin biosynthetic process; IMP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IEP:TAIR.
DR Gene3D; 1.10.110.10; -; 1.
DR InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR InterPro; IPR000528; Plant_nsLTP.
DR PANTHER; PTHR33076; PTHR33076; 1.
DR Pfam; PF00234; Tryp_alpha_amyl; 1.
DR PRINTS; PR00382; LIPIDTRNSFER.
DR SMART; SM00499; AAI; 1.
DR SUPFAM; SSF47699; SSF47699; 1.
DR PROSITE; PS00597; PLANT_LTP; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Lipid-binding; Reference proteome; Signal; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..118
FT /note="Non-specific lipid-transfer protein 2"
FT /id="PRO_0000018362"
FT DISULFID 29..76
FT /evidence="ECO:0000255"
FT DISULFID 39..53
FT /evidence="ECO:0000255"
FT DISULFID 54..100
FT /evidence="ECO:0000255"
FT DISULFID 74..114
FT /evidence="ECO:0000255"
FT CONFLICT 69
FT /note="D -> N (in Ref. 8; CAA79122)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 118 AA; 11938 MW; 88490E003188B6AC CRC64;
MAGVMKLACM VLACMIVAGP ITANALMSCG TVNGNLAGCI AYLTRGAPLT QGCCNGVTNL
KNMASTTPDR QQACRCLQSA AKAVGPGLNT ARAAGLPSAC KVNIPYKISA STNCNTVR
