NLTP_LACSA
ID NLTP_LACSA Reviewed; 117 AA.
AC A0A2J6KL39;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 1.
DT 03-AUG-2022, entry version 18.
DE RecName: Full=Non-specific lipid-transfer protein Lac s 1 {ECO:0000303|PubMed:12757453, ECO:0000303|PubMed:17349693};
DE Short=nsLTP Lac s 1 {ECO:0000303|PubMed:12757453, ECO:0000303|PubMed:17349693};
DE AltName: Allergen=Lac s 1 {ECO:0000303|PubMed:12757453, ECO:0000303|PubMed:17349693};
DE Flags: Precursor;
GN ORFNames=LSAT_1X82001 {ECO:0000312|EMBL:PLY75677.1};
OS Lactuca sativa (Garden lettuce).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236 {ECO:0000312|EMBL:PLY75677.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Salinas;
RX PubMed=28401891; DOI=10.1038/ncomms14953;
RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L.,
RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H.,
RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.;
RT "Genome assembly with in vitro proximity ligation data and whole-genome
RT triplication in lettuce.";
RL Nat. Commun. 8:14953-14953(2017).
RN [2]
RP PROTEIN SEQUENCE OF 26-37, AND ALLERGEN.
RX PubMed=12757453; DOI=10.1034/j.1398-9995.2003.00097.x;
RA San Miguel-Moncin M., Krail M., Scheurer S., Enrique E., Alonso R.,
RA Conti A., Cistero-Bahima A., Vieths S.;
RT "Lettuce anaphylaxis: identification of a lipid transfer protein as the
RT major allergen.";
RL Allergy 58:511-517(2003).
RN [3]
RP PROTEIN SEQUENCE OF 26-37, IDENTIFICATION BY MASS SPECTROMETRY, ALLERGEN,
RP AND CIRCULAR DICHROISM ANALYSIS.
RX PubMed=17349693; DOI=10.1016/j.molimm.2007.01.030;
RA Hartz C., San Miguel-Moncin M., Cistero-Bahima A., Foetisch K.,
RA Metzner K.J., Fortunato D., Lidholm J., Vieths S., Scheurer S.;
RT "Molecular characterisation of Lac s 1, the major allergen from lettuce
RT (Lactuca sativa).";
RL Mol. Immunol. 44:2820-2830(2007).
CC -!- FUNCTION: Plant non-specific lipid-transfer proteins transfer
CC phospholipids as well as galactolipids across membranes. May play a
CC role in wax or cutin deposition in the cell walls of expanding
CC epidermal cells and certain secretory tissues.
CC {ECO:0000250|UniProtKB:P82007, ECO:0000255|RuleBase:RU000628}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC {ECO:0000269|PubMed:12757453, ECO:0000269|PubMed:17349693}.
CC -!- SIMILARITY: Belongs to the plant LTP family. {ECO:0000255,
CC ECO:0000255|RuleBase:RU000628, ECO:0000305}.
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DR EMBL; NBSK01006983; PLY75677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2J6KL39; -.
DR SMR; A0A2J6KL39; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_1X82001_mrna; cds-PLY75677.1; gene-LSAT_1X82001.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_1X82001_mrna; cds-PLY75677.1; gene-LSAT_1X82001.
DR OrthoDB; 1546493at2759; -.
DR Proteomes; UP000235145; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR Gene3D; 1.10.110.10; -; 1.
DR InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR InterPro; IPR000528; Plant_nsLTP.
DR PANTHER; PTHR33076; PTHR33076; 1.
DR Pfam; PF00234; Tryp_alpha_amyl; 1.
DR PRINTS; PR00382; LIPIDTRNSFER.
DR SMART; SM00499; AAI; 1.
DR SUPFAM; SSF47699; SSF47699; 1.
DR PROSITE; PS00597; PLANT_LTP; 1.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Disulfide bond; Lipid-binding;
KW Reference proteome; Signal; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|PubMed:12757453,
FT ECO:0000269|PubMed:17349693"
FT CHAIN 26..117
FT /note="Non-specific lipid-transfer protein Lac s 1"
FT /evidence="ECO:0000255, ECO:0000305|PubMed:12757453,
FT ECO:0000305|PubMed:17349693"
FT /id="PRO_5014448417"
FT DISULFID 29..76
FT /evidence="ECO:0000250|UniProtKB:Q9ATH2"
FT DISULFID 39..53
FT /evidence="ECO:0000250|UniProtKB:Q9ATH2"
FT DISULFID 54..99
FT /evidence="ECO:0000250|UniProtKB:Q9ATH2"
FT DISULFID 74..113
FT /evidence="ECO:0000250|UniProtKB:Q9ATH2"
SQ SEQUENCE 117 AA; 11957 MW; 36C7E2F32ED91434 CRC64;
MARMAMMILC VVLTCMVVAT PYTEAAISCG QVTANLAGCL NYLRNGGAVP PACCNGVRSL
NSAAKSTPDR KTACNCLKNA SKSVSGIKAA NAAGLPGKCG VNIPYQISPN TDCSKVQ
