ID   NLTP_MALDO              Reviewed;         115 AA.
AC   Q9M5X7; Q9LED0;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Non-specific lipid-transfer protein;
DE            Short=LTP;
DE   AltName: Allergen=Mal d 3;
DE   Flags: Precursor;
GN   Name=MALD3;
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Golden Delicious;
RA   Scheurer S., Wangorsch A., Haustein D., Vieths S.;
RT   "Cloning of a cDNA encoding a lipid transfer protein as a potential
RT   allergen from Malus domestica.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 25-115.
RA   Diaz-Perales A., Garcia-Casado G., Sanchez-Monge R., Barber D., Salcedo G.;
RT   "Cloning of a cDNA encoding a major allergen and lipid transfer protein,
RT   from Malus domestica.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plant non-specific lipid-transfer proteins transfer
CC       phospholipids as well as galactolipids across membranes. May play a
CC       role in wax or cutin deposition in the cell walls of expanding
CC       epidermal cells and certain secretory tissues (By similarity).
CC       {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the plant LTP family. {ECO:0000305}.
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DR   EMBL; AF221502; AAF26450.1; -; mRNA.
DR   EMBL; AJ277164; CAB96874.1; -; mRNA.
DR   RefSeq; NP_001281295.1; NM_001294366.1.
DR   AlphaFoldDB; Q9M5X7; -.
DR   SMR; Q9M5X7; -.
DR   STRING; 3750.XP_008388342.1; -.
DR   Allergome; 466; Mal d 3.
DR   EnsemblPlants; mRNA:MD12G0154500; mRNA:MD12G0154500; MD12G0154500.
DR   GeneID; 103450745; -.
DR   Gramene; mRNA:MD12G0154500; mRNA:MD12G0154500; MD12G0154500.
DR   KEGG; mdm:103450745; -.
DR   OrthoDB; 1546493at2759; -.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR000528; Plant_nsLTP.
DR   PANTHER; PTHR33076; PTHR33076; 1.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   PRINTS; PR00382; LIPIDTRNSFER.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
DR   PROSITE; PS00597; PLANT_LTP; 1.
PE   1: Evidence at protein level;
KW   Allergen; Disulfide bond; Lipid-binding; Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..115
FT                   /note="Non-specific lipid-transfer protein"
FT                   /id="PRO_0000018390"
FT   DISULFID        27..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..111
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   115 AA;  11410 MW;  CF431D5A52AD8C95 CRC64;
     MASSAVTKLA LVVALCMAVS VAHAITCGQV TSSLAPCIGY VRSGGAVPPA CCNGIRTING
     LARTTADRQT ACNCLKNLAG SISGVNPNNA AGLPGKCGVN VPYKISTSTN CATVK