ID   NLTP_MORCI              Reviewed;          33 AA.
AC   C0HJH5;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2015, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Non-specific lipid-transfer protein {ECO:0000303|PubMed:26783638};
DE   AltName: Full=McLTP1 {ECO:0000303|PubMed:26783638};
DE   Flags: Fragment;
OS   Morinda citrifolia (Indian mulberry).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Gentianales; Rubiaceae; Rubioideae; Morindeae; Morinda.
OX   NCBI_TaxID=43522 {ECO:0000303|PubMed:26783638};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, AND MASS SPECTROMETRY.
RC   TISSUE=Seed {ECO:0000303|PubMed:26783638};
RX   PubMed=26783638; DOI=10.1016/j.ijbiomac.2016.01.029;
RA   Campos D.C., Costa A.S., Lima A.D., Silva F.D., Lobo M.D.,
RA   Monteiro-Moreira A.C., Moreira R.A., Leal L.K., Miron D., Vasconcelos I.M.,
RA   Oliveira H.D.;
RT   "First isolation and antinociceptive activity of a lipid transfer protein
RT   from noni (Morinda citrifolia) seeds.";
RL   Int. J. Biol. Macromol. 86:71-79(2016).
RN   [2]
RP   FUNCTION.
RC   TISSUE=Seed {ECO:0000303|PubMed:28559184};
RX   PubMed=28559184; DOI=10.1016/j.ijbiomac.2017.05.148;
RA   Campos D.C.O., Costa A.S., Luz P.B., Soares P.M.G., Alencar N.M.N.,
RA   Oliveira H.D.;
RT   "Morinda citrifolia lipid transfer protein 1 exhibits anti-inflammatory
RT   activity by modulation of pro- and anti-inflammatory cytokines.";
RL   Int. J. Biol. Macromol. 103:1121-1129(2017).
RN   [3]
RP   FUNCTION.
RC   TISSUE=Seed {ECO:0000303|PubMed:28559184};
RX   PubMed=29577952; DOI=10.1016/j.biochi.2018.03.011;
RA   Souza A.A., Costa A.S., Campos D.C.O., Batista A.H.M., Sales G.W.P.,
RA   Nogueira N.A.P., Alves K.M.M., Coelho-de-Souza A.N., Oliveira H.D.;
RT   "Lipid transfer protein isolated from noni seeds displays antibacterial
RT   activity in vitro and improves survival in lethal sepsis induced by CLP in
RT   mice.";
RL   Biochimie 149:9-17(2018).
CC   -!- FUNCTION: Plant non-specific lipid-transfer proteins transfer
CC       phospholipids as well as galactolipids across membranes (By
CC       similarity). May play a role in wax or cutin deposition in the cell
CC       walls of expanding epidermal cells and certain secretory tissues (By
CC       similarity). Has antibacterial activity against Gram-positive bacteria
CC       S.aureus and S.epidermidis and blocks biofilm formation
CC       (PubMed:29577952). In a mouse model, also protects against bacterial
CC       sepsis and has an anti-inflammatory effect (PubMed:29577952,
CC       PubMed:28559184). Exhibits antinociceptive activity upon oral or
CC       intraperitoneal application in mice (PubMed:26783638).
CC       {ECO:0000250|UniProtKB:Q42952, ECO:0000269|PubMed:26783638,
CC       ECO:0000269|PubMed:28559184, ECO:0000269|PubMed:29577952}.
CC   -!- SUBUNIT: Dimer. {ECO:0000269|PubMed:26783638}.
CC   -!- MASS SPECTROMETRY: Mass=9450; Method=Electrospray; Note=Two determined
CC       masses suggest presence of different isoforms.;
CC       Evidence={ECO:0000269|PubMed:26783638};
CC   -!- MASS SPECTROMETRY: Mass=9466; Method=Electrospray; Note=Two determined
CC       masses suggest presence of different isoforms.;
CC       Evidence={ECO:0000269|PubMed:26783638};
CC   -!- SIMILARITY: Belongs to the plant LTP family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HJH5; -.
DR   SMR; C0HJH5; -.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR000528; Plant_nsLTP.
DR   PRINTS; PR00382; LIPIDTRNSFER.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Lipid-binding; Transport.
FT   CHAIN           1..>33
FT                   /note="Non-specific lipid-transfer protein"
FT                   /id="PRO_0000432829"
FT   DISULFID        4..?
FT                   /evidence="ECO:0000250|UniProtKB:P81402"
FT   DISULFID        14..29
FT                   /evidence="ECO:0000250|UniProtKB:P81402"
FT   DISULFID        30..?
FT                   /evidence="ECO:0000250|UniProtKB:P81402"
FT   NON_TER         33
FT                   /evidence="ECO:0000303|PubMed:26783638"
SQ   SEQUENCE   33 AA;  3203 MW;  27C9E66AF888F929 CRC64;
     AVPCGQVSSA LSPCMSYLTG GGDDPEARCC AGV