ID   NM111_ASPCL             Reviewed;        1028 AA.
AC   A1CUK5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Pro-apoptotic serine protease nma111;
DE            EC=3.4.21.-;
GN   Name=nma111; ORFNames=ACLA_086940;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; DS027060; EAW06992.1; -; Genomic_DNA.
DR   RefSeq; XP_001268418.1; XM_001268417.1.
DR   AlphaFoldDB; A1CUK5; -.
DR   SMR; A1CUK5; -.
DR   STRING; 5057.CADACLAP00007750; -.
DR   EnsemblFungi; EAW06992; EAW06992; ACLA_086940.
DR   GeneID; 4699972; -.
DR   KEGG; act:ACLA_086940; -.
DR   VEuPathDB; FungiDB:ACLA_086940; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   OMA; CVFDNHE; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF17820; PDZ_6; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..1028
FT                   /note="Pro-apoptotic serine protease nma111"
FT                   /id="PRO_0000320345"
FT   DOMAIN          289..374
FT                   /note="PDZ 1"
FT   DOMAIN          876..957
FT                   /note="PDZ 2"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          82..266
FT                   /note="Serine protease"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        120
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        151
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        233
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1028 AA;  113349 MW;  2BD4FA9474C11A31 CRC64;
     MDMSGESSIK RRRSSIAASA ERPAKHLRPE NSTLTPGDAT PANGTVYAVE DEGDAGRMMP
     IGPAQADSPE WQATIENVVK SVVSIHFCQT CSFDTDMSMS SQATGFVVDA ERGYILTNRH
     VVCAGPFWGY CIFDNHEECD VRPVYRDPVH DFGILKFDPK AIRYLELTEL KLRPEAARVG
     SEIRVVGNDA GEKLSILSGV ISRLDRNAPE YGDGYCDFNT NYIQAAAAAS GGSSGSPVVN
     IDGHAIALQA GGRADGAATD YFLPLDRPLR ALQCIQRGEP VTRGTIQTQW ILKPFDECRR
     LGLTPDWEAA VRKAAPQETS MLVAEIILPE GPADGKLEEG DVLLQVNGEL LTQFIRLDDI
     LDSSVGKPVR LLVQRGGQNV EVECEVGDLH AITPDRFVTV AGGTFHNLSY QQARLYAIAT
     RGVYICEAAG SFKLENTLSG WIIDSVDKRP TRNLDEFIEV MRAIPDRSRV VVSYRHIRDL
     HTRGTGIVYI DRHWHPKMRM AVRNDGTGLW DFSDLADPVP AAAPVPRKAD FIHLDGVSQA
     AVSDIVRSFV RVSCTMPLKL DGYPQAKKTG YGLVVDAEKG LVVVSRAIVP YDLCDINITV
     ADSIIVTAQV VFLHPLQNYT VIQYDPSLVQ APVQSAKLST EYIKQGQETI FVGFNQNFRI
     VVAKTTVTDI TTVSIPANAS APRYRAINLD AVTVDTGLSG QCTNGVLIGE DGVVQALWLN
     YLGERTPSSH KDVEYHLGFA TPALLPVTTK IQQGIIPKLR ILNMESYVVQ MSQARIMGVS
     EQWIQKVAQA NPARHQLFMV RKVDCPPPQY SSTADALEEG DIILTLDGKL ITRVSELDTM
     YDKEVLDVLI VRNGEELHLK VPTIPTEDLE TDRAVVFCGA VLQKPHHAVR QQISKLHSEV
     YVSARSRGSP AYQYGLSPTN FITAVNGVPT PNLDSFVREV SKIPDNTYFR LRAVTFDNVP
     WVVTMKKNDH YFPMSEYIKD PSQPLGWLTV SHDRDRHKDG ITPDQANLNP DAMDEAFEQV
     SDVEPDVE