NM111_ASPFU
ID NM111_ASPFU Reviewed; 1028 AA.
AC Q4WLG1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Pro-apoptotic serine protease nma111;
DE EC=3.4.21.-;
GN Name=nma111; ORFNames=AFUA_6G13650;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR EMBL; AAHF01000006; EAL89203.1; -; Genomic_DNA.
DR RefSeq; XP_751241.1; XM_746148.1.
DR AlphaFoldDB; Q4WLG1; -.
DR SMR; Q4WLG1; -.
DR STRING; 746128.CADAFUBP00000108; -.
DR MEROPS; S01.434; -.
DR EnsemblFungi; EAL89203; EAL89203; AFUA_6G13650.
DR GeneID; 3508556; -.
DR KEGG; afm:AFUA_6G13650; -.
DR eggNOG; KOG1421; Eukaryota.
DR HOGENOM; CLU_003212_0_0_1; -.
DR InParanoid; Q4WLG1; -.
DR OMA; CVFDNHE; -.
DR OrthoDB; 93889at2759; -.
DR Proteomes; UP000002530; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR Pfam; PF12812; PDZ_1; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; SSF50156; 3.
DR SUPFAM; SSF50494; SSF50494; 2.
PE 3: Inferred from homology;
KW Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW Serine protease.
FT CHAIN 1..1028
FT /note="Pro-apoptotic serine protease nma111"
FT /id="PRO_0000320346"
FT DOMAIN 289..374
FT /note="PDZ 1"
FT DOMAIN 876..957
FT /note="PDZ 2"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..266
FT /note="Serine protease"
FT REGION 991..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 120
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 151
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 233
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1028 AA; 113599 MW; 7ACA0F9D82A7B8FB CRC64;
MDLNGETSTK RKRSSVAAPA ERPAKHLKPG NSTLTPGDAT PANGTVYNVE DEEDTGRVMP
IGPAQADSPE WQATIEKVVK SVVSIHFCQT CSFDTDLSMS SQATGFVVDA ERGYILTNRH
VVCAGPFWGY CIFDNHEECD VHPVYRDPVH DFGILKFNPK AIRYMELTEL KLRPEAARVG
CEIRVVGNDA GEKLSILSGV ISRLDRNAPE YGDGYCDFNT NYIQAAAAAS GGSSGSPVVN
IDGHAIALQA GGRADGAATD YFLPLDRPLR ALECIRRGEP VTRGTIQTQW ILKPFDECRR
LGLTPEWEAA VRKASPHETS MLVAEIILPE GPADGKLEEG DVLLQVNGEL LTQFIRLDDI
LDSSVGKTVR LLVQRGGQNV EVECEVGDLH AITPDRFVTV AGGTFHNLSY QQARLYAIAA
RGVYVCEAAG SFKLENTLSG WIIDAVDKRP TRNLDEFIEV MKTIPDRARV VISYRHIRDL
HTRGTSIVYI DRHWHPKMRM AIRNDETGLW DFSDLADPVP AETPVPRKAD FIQLDGVSQP
AVADIVRSFV RVSCTMPLKL DGYPQAKKTG FGLVIDAGKG LVVVSRAIVP YDLCDINITV
ADSIIVVAKV IFMHPLQNYT IIQYDPSLVQ APVQSAELST EYIKQGQETI FVGFNQNFRI
VVAKTAVTDI TTVSIPANAS APRYRAINLD AITVDTGLSG QCTNGVLIGE DGVVQALWLN
YLGERTPNSH KDVEYHLGFA TPALLPVTSK IQQGIIPKLR ILNMESYVVQ MSQARIMGVS
EEWIQKVAQA NPSRHQLFMV RKVDCPPPQF TSNADSLQEG DIILTLDGQL ITRVSELDKM
YEKEVLDALI VRNGQEIHLK LPTVPTEDLE TDRAVVFCGA VLQKPHHAVR QQISKLHSEV
YVSARSRGSP AYQYGLAPTN FITAVNGVST PNLDSFVREV SMIPDNTYFR LRAVTFDNVP
WVVTMKKNDH YFPMSEYVKD PSQPLGWRTV SHERDRHKDG ITPDAANLNP DAMDEVYEEV
SDVEPEVD
