ID   NM111_ASPOR             Reviewed;        1027 AA.
AC   Q2TYB1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Pro-apoptotic serine protease nma111;
DE            EC=3.4.21.-;
GN   Name=nma111; ORFNames=AO090103000320;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; AP007174; BAE65762.1; -; Genomic_DNA.
DR   RefSeq; XP_001826895.2; XM_001826843.2.
DR   AlphaFoldDB; Q2TYB1; -.
DR   SMR; Q2TYB1; -.
DR   STRING; 510516.Q2TYB1; -.
DR   EnsemblFungi; BAE65762; BAE65762; AO090103000320.
DR   GeneID; 5999186; -.
DR   KEGG; aor:AO090103000320; -.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   OMA; CVFDNHE; -.
DR   Proteomes; UP000006564; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF17820; PDZ_6; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..1027
FT                   /note="Pro-apoptotic serine protease nma111"
FT                   /id="PRO_0000320347"
FT   DOMAIN          288..373
FT                   /note="PDZ 1"
FT   DOMAIN          875..956
FT                   /note="PDZ 2"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..265
FT                   /note="Serine protease"
FT   REGION          991..1027
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        119
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        150
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        232
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1027 AA;  113315 MW;  119F18B7C8F87D3F CRC64;
     MDLNGDAGAK RKRSSIVPAE RPAKHLKPES SALTPGDSTP ANGTVYDIED EDDASRLLPI
     GPAQADSPEW QATIEEVVKS VVSIHFCQTC SFDTELSMSS QATGFVVDAE RGYILTNRHV
     VCPGPFWGYC IFDNHEECDV RPVYRDPVHD FGILKFDPKA IRYMNLTELK LQPDAARVGS
     EIRVVGNDAG EKLSILSGVI SRLDRNAPEY GEGYSDFNTN YIQAAAAASG GSSGSPVVNI
     DGHAIALQAG GRADGAATDY FLPLDRPLRA LECIRRGEPV TRGTIQTQWI LKPFDECRRL
     GLTPEWEATV RKAAPTETSM LVAEIILPEG PADGKLEEGD VLLQVNGELL TQFIRLDDIL
     DSSVGQTVRL LVQRGGQDVE IECQVGDLHA ITPDRFVTVA GGTFHDLSYQ QSRLYAIATR
     GVYVCEAAGS FKLENTLSGW LIDSVDKRPT RNLDEFVEVM KTIPDRSRVV ISYRHIRDLH
     TRGTSIVYID RHWHPKMRLA VRNDETGLWD FSDLADALPA LPPVPRKADF IQLDGVSQPA
     ASEIVRSFVR VSCTMPLKLD GYPQAKKTGF GLVVDAEKGL VVVSRAIVPY DLCDINITVA
     DSIIVNAKVV FLHPLQNYTI IQYDPSLVQA PVQSAKLSTE YIKQGQDTIF VGFNQNFRIV
     VAKTAVTDIT TVSIPANASA PRYRAINLDA VTVDTGLSGQ CSNGVLIGED GVVQALWLNY
     LGERTPSSHK DVEYHLGFAT PSLLPVVSKI QQGVMPELRI LNMESYVVQM SQARIMGVSE
     EWIEKVTQAN PSRHQLFMVR KVDCPPAGFD NMADTFQEGD ILLTLDGQLI TRVSELDVMY
     DKEFLEALIV RNGQEMRIQV PTVPTADLET DRAVVFCGAV LQKPHHAVRQ QISKLHSEIY
     VSARSRGSPS YQYGLSPTNF ITAVNGVPTP DLDRFVKEVS KIPDNTYFRL RAVTFDNVPW
     VVTMKKNDHY FPMSEYLKDP SQPCGWRTVS HNKSKHKDGI APDAANLNPD AMEQGYDGAS
     DIEPEAE