ID   NM111_CHAGB             Reviewed;        1030 AA.
AC   Q2H334;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; ORFNames=CHGG_03812;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; CH408032; EAQ87193.1; -; Genomic_DNA.
DR   RefSeq; XP_001223026.1; XM_001223025.1.
DR   AlphaFoldDB; Q2H334; -.
DR   SMR; Q2H334; -.
DR   STRING; 38033.XP_001223026.1; -.
DR   EnsemblFungi; EAQ87193; EAQ87193; CHGG_03812.
DR   GeneID; 4392816; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   InParanoid; Q2H334; -.
DR   OMA; CVFDNHE; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..1030
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320350"
FT   DOMAIN          312..384
FT                   /note="PDZ 1"
FT   DOMAIN          880..960
FT                   /note="PDZ 2"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..279
FT                   /note="Serine protease"
FT   COMPBIAS        12..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        127
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        158
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        240
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1030 AA;  113704 MW;  8FAA33C19804222C CRC64;
     MNGTTSPIAA RSKRKEPPHT VDGRHPKHHR TNGEVAPAAD NTPDNQDEFE GEFGVELEEY
     EDARLPAVLP TGPDTAEWQA TIQRVVRNVV SIRFCQTCSF DTDPALTSEA TGFVVDAERG
     YILTNRHVVG SGPFWGYCIF DNHEEVDAYP VYRDPVHDFG ILKFDPKAIK YMPVDALPLR
     PDLAKVGIEI RVVGNDAGEK LSILSGVISR LDRNAPEYGE GYSDFNTCYY QASAAASGGS
     SGSPVVNMDG YAVALQAGGR ADGAATDYFL PLDRPLRALK CLQEGNPITR GDIQCQFVLK
     PFDECRRLGL TPEWEAQIRK AFPKETNMLV AEIVLPEGPS HKKAEEGDVL IKVNGELLTQ
     FIRLDDILDS SVGKPVKLLL LRGGEEIEVE IEVGDLHSIT PDRFVSVAGG SFHSLSYQQA
     RLYGVACKGV FVCEAGGSFR FDNAENGWLI QTVDHKKTPD LETFIEVMKG IHDKARVVVT
     YKHLRDLHTL NTTILHIDRH WSKKMKLAVR NDETGLWDFT NLADPLPPVA PIPRKADFIQ
     LEHTSHPAVA DLVRSFVHVS CVMPVKLDGF PKNRKWGMGL VIDADKGLVV ISRAIVPYDL
     CDITVTIADS IVVEGKVVFL HPLQNYAIIQ YDPKLVDAPV LSARLSSQEI TQGASTYFIG
     YNRIGRIVHA ATTVTEIFAV TIPANSGAPR YRAVNVDAIT VDTSLSGQCG SGVLVAQDGT
     VQALWLTYLG ERNPSTHRDE EYHLGLATPT LLPVVEQIQR GVDPKLRMLS VEFRAIQMSQ
     ARLMGVSEEW IQKVSVANTA HHQLFMVTKR TFERNEQEEA AALLEGDVVL SLNGKIITKI
     SDLDIMYSNE QLDAVLVRNC EELSLKLDTV AADDVETTRA VSFCGAIFHA PHHAVRQQIS
     KLFSEVYVSA RTRGSPSYQY GLAPTNFITH VNGKPTPDLE AFLAEVVKIP DNTYFRLRAM
     SFDSVPWVVT MKKNDHYFPT MELIKDPKEE CGWRRITYEG GKVIQGEGPD GVVGSAGEIT
     DMDVDADVCG