ID   NM111_COCIM             Reviewed;        1034 AA.
AC   Q1E3N5; J3KAD6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; ORFNames=CIMG_02828;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAS37474.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; GG704911; EAS37474.3; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001249057.1; XM_001249056.2.
DR   AlphaFoldDB; Q1E3N5; -.
DR   SMR; Q1E3N5; -.
DR   STRING; 246410.Q1E3N5; -.
DR   EnsemblFungi; EAS37474; EAS37474; CIMG_02828.
DR   GeneID; 4565254; -.
DR   KEGG; cim:CIMG_02828; -.
DR   InParanoid; Q1E3N5; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..1034
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320351"
FT   DOMAIN          296..381
FT                   /note="PDZ 1"
FT   DOMAIN          882..963
FT                   /note="PDZ 2"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..273
FT                   /note="Serine protease"
FT   REGION          1004..1034
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        127
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        158
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        240
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1034 AA;  114094 MW;  BD64484841859AA2 CRC64;
     MELNGSPQKP KRKHSGDPHS LPSAKHLRPD SAAPSSPRIS GDQTSGDLAV YGYRNVDSAD
     AAAMQMKLPA VQTDSAEWQE TIETVVKSVV SIHFCQTASF DTDLSMSSQA TGFVVDAKRG
     YILTNRHVVC AGPFWGYCIF DNHEECDVTP IYRDPVHDFG ILKFDPKAIK YMPLTELKLQ
     PESARVGVEI RVVGNDAGEK LSILSGVISR LDRNAPEYGE GYSDFNTNYI QAAAAASGGS
     SGSPVVNIDG HVIALQAGGR ADGAATDYFL PLDRPLRALQ CIQKGELVSR GTIQTQWIIK
     PFDECRRLGL SPEWEAEVRR VAPKETGMLV AEIVLPEGPG DGKLQEGDVL IKANGELLTQ
     FVRLDDILDS SVGGDVHLLV QRGGEDLEVT CKVQDLHAIT PSRYVTVAGA TFHDLSYQQA
     RLYAIACKGV YVCEAAGSFK LESTFSGWII DSVDKRPTRN LDEFIEVLKT IPDRARIVLS
     YRHIRDLHTR GTSIVHIDRH WHPHMRLAQR NDQTGLWDFT DLADPIPAEP PVPRKADFIQ
     LDGVSHPAAA DIVRSFVRVS CTMPVKLDGF PQARKTGFGL VVDAEKGLVV ISRAIVPFDL
     CDINITVADS IIVSAKVVFL HPLQNYTIIQ YDPSLVQAPV KTARLSPEYI KQGAETLFVG
     FNQNFRIVVA KTAVTDITTV AIPPNAAAPR YRAINLDAIT VDTGLSSQCT SGVLLGEDGV
     IQALWLNYLG ERTQSSHKDV EYHLGLATPS LIPVISQIQS GVIPRLRILD METYVIQMSQ
     ARVMGVSEEW IEKVAKANAA RHELFMVRKV DCASPLSADV RPLEEGDIIL TLNDKLITRV
     SEFDMMYDQE TLDALIVRNG EEMKIKIKTV PTEDLETDRA LIFCGAVLQK PHHAVRQQIS
     KLHSEVYVSA RSRGSPAYQY GLSPTNFITA VNGVKTPDLD SFIREVSNIP NNTYFRLRAV
     TFDNVPWVVT MKKNDHYFPM SEYIKEPSAP LGWRTVNYDR GKERRGTGDI ANLNADAMDE
     GRDEGVSDVE PDIE