ID   NM111_DEBHA             Reviewed;         987 AA.
AC   Q6BKM0; B5RUK4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; OrderedLocusNames=DEHA2F20768g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; CR382138; CAR66382.1; -; Genomic_DNA.
DR   RefSeq; XP_002770862.1; XM_002770816.1.
DR   AlphaFoldDB; Q6BKM0; -.
DR   SMR; Q6BKM0; -.
DR   STRING; 4959.XP_002770862.1; -.
DR   EnsemblFungi; CAR66382; CAR66382; DEHA2F20768g.
DR   GeneID; 8999024; -.
DR   KEGG; dha:DEHA2F20768g; -.
DR   VEuPathDB; FungiDB:DEHA2F20768g; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   InParanoid; Q6BKM0; -.
DR   OMA; CVFDNHE; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF17820; PDZ_6; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 3.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..987
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320352"
FT   DOMAIN          279..364
FT                   /note="PDZ 1"
FT   DOMAIN          878..950
FT                   /note="PDZ 2"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..262
FT                   /note="Serine protease"
FT   COMPBIAS        11..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        110
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        141
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        224
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   987 AA;  110741 MW;  4269B20729DA6C35 CRC64;
     MPDIPTKRRL SNGSVIDNTN KRQMQSSFVP EVEQESDGYL SEDSSDQPIF DMAVAANSNQ
     WQETITKVVK SVVSIQFTHV SNFDTESSIV SEATGFVVDA KRGLILTNRH VVGPGPFCGY
     VVFDNHEEAV VKPIYRDPVH DFGFLQFDAK SIKYMDVTQL ELKPDLAKVG TEIRVVGNDA
     GEKLSILAGF ISRLDRNAPD YGALTYNDFN TEYIQAAASA SGGSSGSPVV NEDGHAVAIQ
     AGGSSEASTD FFLPVYRPLR ALRCIQESQP ITRGDIQVEW SLKPFDECRR LGLTSEAERI
     ARERFPDKIG LLVAELVLPE GPADELIKEG DTLISINDEP ISTFIKVDEI LDESVGKELK
     VVIQRGGEEI TQTIKIGDLH SITPDRYVDV AGASFNQMSY QVARCYCIPV KGVYINDASG
     SFEFSTFEKT GWLLETVDDK QTPDLDTFIE VMKQIPDRQK VTITYRHVSD LHTESIQVIY
     IERHWQSTFR LAVRNDKSGL WDFTDIQDKP LPPLKLEPQN AKYINIPFEN EEKQGCASLV
     KSFVQVRTVA PVPMDSYPYR KEIGYGVVVD ATNGYVLVSR RFVPHDMCDI FVIFAESVDI
     PGKVVFLHPN QNYAIIKYDP KLVLADVQAP KFSDKPLKRG EKSFFVGYNY NLRLVTEDVK
     VSGISSLNVP AASLSPRYRG TNLECVLLDS KLCQECDSGV LADEDGTLRS FWLSYLGESN
     CDQTTDRMYR MGLDVTDVLD VINKLKDNEI PVDLRILDAE FSSITILQGR TRGVPQKWIN
     EFEKVCHDEL KFLSVERVAA AKLNQTPNPL KIGDILLSVN GSIVKTMRDL KIMYNKPSLD
     FKIIRSKKEM DITVPTVETT SLNTSHVVFW CGAILQAPHH GVRQLMEKIP SEVYVTRKNS
     GGPAHQYGIV TNSFITHVND KETKNLESFM DAITDIADNT YIKLRLVSFD NVPVAISVKT
     NYHYFPTAEL KKNKETGEWK EIEHKEK