ID   NM111_LODEL             Reviewed;         979 AA.
AC   A5DVI0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; ORFNames=LELG_01366;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; CH981525; EDK43188.1; -; Genomic_DNA.
DR   RefSeq; XP_001526538.1; XM_001526488.1.
DR   AlphaFoldDB; A5DVI0; -.
DR   SMR; A5DVI0; -.
DR   STRING; 379508.A5DVI0; -.
DR   MEROPS; S01.434; -.
DR   EnsemblFungi; EDK43188; EDK43188; LELG_01366.
DR   GeneID; 5234307; -.
DR   KEGG; lel:LELG_01366; -.
DR   VEuPathDB; FungiDB:LELG_01366; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   InParanoid; A5DVI0; -.
DR   OMA; CVFDNHE; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..979
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320354"
FT   DOMAIN          277..362
FT                   /note="PDZ 1"
FT   DOMAIN          871..943
FT                   /note="PDZ 2"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..260
FT                   /note="Serine protease"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        108
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        139
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        222
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   979 AA;  109304 MW;  8753B9F5BCB69A8A CRC64;
     MKRNGESHLN GEAKKSRTEQ NQEQQDYQDE YYSSSDEELL PSSQTSPVFD IAHSNSDKWQ
     STIRKVVNSV VSIQFSHVAA FDTETALVSE ATGFVVDAER GLILTNRHVV GPGPFTGYVV
     FDNHESVDVK PIYRDPVHDF GFLQFDTKDV KYLKLTQLDL DPSLAKIGTE IRVVGNDNGE
     KLSILAGIIS RIDRNAPDYG ALTYNDFNTE YIQAAASATG GSSGSPVVNE DGKCVALQAG
     GSTEASTDFF LPVSRPKRAL QCIQKGLPIT RGDIQVEWQL KPFDECARLG FTAEAEAEAR
     KMFPDKIGML VAELVLPEGP ADGLIKEGDT LISIQGEYIS TFVRVDEILD ENVGKELEFV
     FQRSGREIKQ MIKIGNLHAI TPDRFVHVAG ASFNNLSYQV ARCYCLPVRG LYVCDGSGSF
     EFSNQDTLGF IVETVDDKPV ANLDEFVEVM KQLPDCSRVP VVYRHVSDMH AEYVQTIYID
     RHWYTSFKLA VRNDTTGLWD FTTLQKEALP PAALVPQNAK YVDIPFSDPS RAECSKLVRS
     FVQVRTLCPS GVDSHPFKKD IGYGVVVDST NGYVLVSRRY VPHYMCDIFV VFAESIDVAG
     EVVFLHPHLN YAIIKYDPKL VLADVQSPKF SETPLKRGDD LFFIGYNYNL RVVTDDVKVS
     SISSLNVTAN SIAPRYRGTN LECILLDSKL THECNTGVLV DNDGTLRAFW LSYLGESNEL
     SFKMGLDVTD VLSILKSLQA NHIPKSLRML DAEFASLTVL QGRTRGVPQT WIKRFEDEAQ
     DLIKFLSVDR VSAPTFEAKP SPLKVGDIVL SVNGKLVKNM RDFASMYDET SLTFNIIRQK
     QEMTLEVPTI DTTSMETSHV VSWSGALLQK PHYGVRQLMT KIPSEVYIVD KSSCGPAHQY
     GIVPISFITH VNDQETKDLD SFIQVVKLIP DKTYVKLRLV SFDNIPAAIS LKTDYHYFPT
     TTLKRDAVSG KWNTEKINE