ID   NM111_MAGO7             Reviewed;        1029 AA.
AC   A4RJH4; G4MW74;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; ORFNames=MGG_01824;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EHA55034.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CM001232; EHA55034.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_003714841.1; XM_003714793.1.
DR   AlphaFoldDB; A4RJH4; -.
DR   SMR; A4RJH4; -.
DR   STRING; 318829.MGG_01824T0; -.
DR   PRIDE; A4RJH4; -.
DR   GeneID; 2679201; -.
DR   KEGG; mgr:MGG_01824; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   InParanoid; A4RJH4; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000009058; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..1029
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320355"
FT   DOMAIN          307..379
FT                   /note="PDZ 1"
FT   DOMAIN          845..958
FT                   /note="PDZ 2"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..274
FT                   /note="Serine protease"
FT   REGION          997..1029
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        122
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        153
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        235
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1029 AA;  113492 MW;  3701A231559C249D CRC64;
     MNGPTSQRAK RKQGSASSLD DRPPKHQRAL NGAKQQSTGD NTPEEDMYDQ GLDDEDLLAQ
     ALLPSVGPDT VEWQATIQKV VSNVVSIRFC QTCSFDTDAA LTSEATGFVV DAERGYILTN
     RHVVGSGPFW GYCIFDNHEE VDAYPVYRDP VHDFGILKFD PKAIKYMPVA ALPLRPDLAK
     VGVEIRVVGN DAGEKLSILS GVISRLDRNA PEYGEGYSDF NTCYYQASAA ASGGSSGSPV
     VNIDGFAVAL QAGGRADGAS TDYFLPLDRP LRALQCLQQG KPITRGDIQC QFLLKPFDEC
     RRLGLAPEWE AQMRKAFPKE TNLLVAEIIL PEGPSSNKVE EGDVLLKVNE ELITEFIRLD
     DILDSNVGKP VKLLLQRGGE DVEVEVDVGD LHSITPDRFV SVAGGSFHSL SYQQARLYGV
     ACKGVYVCEA TGSFRFETSD NGWILQTIDN KKVPDLETFI QVVKNIPDKA RVVVTYKHLR
     DLHTLNTTII YVDRHWSSKM KLAVRNDDTG LWDFTDLADA LPPVPPVPRK ASFIQLEHTS
     HPAVAELVRS FVHVTCTMPM KLDGFPKNRK WGMGLVIDAE KGLVVISRAI VPYDLCDISI
     TIGESIVVEG KVVFLHPLQN YAIIQYDPKL VDAPVQSAKL SSEEITQGAS TYFIGYNRIG
     RVVHTATTVT EIFAVAIPAN SGAPRYRAVN VDAITVDTNL SGQCGSGVLV APDGTVQALW
     LTYLGERSPS THRDEEYHLG LATPTLLPVV KQIQQGIVPK LRMLSVEFRS IQMAQARIMG
     VSEEWIQQVS LANTSHHQLF MVTKRTFERD QDENSGALLE GDILLTLNDK LITRISELDI
     MYSHEFLGAV IVRETKELKL KLPTVAADDV ETDHAVSFCG AIFHRPHQAV RQQISKLYSE
     VYVSARTRGS PSYQYGLAPT NFITHVNGKR TPDLKTFLAA VTAIPDNTYF RLKAVTFDSV
     PWVVTMKKNE HYFPTVEWIK DSSEDCGWRR VTYEGGKAME GEPSEGVPAV EEEAGGAVDD
     DVPMAAVEK