ID   NM111_NEOFI             Reviewed;        1028 AA.
AC   A1DP85;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Pro-apoptotic serine protease nma111;
DE            EC=3.4.21.-;
GN   Name=nma111; ORFNames=NFIA_059600;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW16606.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DS027698; EAW16606.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001258503.1; XM_001258502.1.
DR   AlphaFoldDB; A1DP85; -.
DR   SMR; A1DP85; -.
DR   STRING; 36630.CADNFIAP00004332; -.
DR   EnsemblFungi; EAW16606; EAW16606; NFIA_059600.
DR   GeneID; 4585019; -.
DR   KEGG; nfi:NFIA_059600; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF17820; PDZ_6; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..1028
FT                   /note="Pro-apoptotic serine protease nma111"
FT                   /id="PRO_0000320356"
FT   DOMAIN          305..377
FT                   /note="PDZ 1"
FT   DOMAIN          876..957
FT                   /note="PDZ 2"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          82..266
FT                   /note="Serine protease"
FT   REGION          989..1028
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        120
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        151
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        233
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1028 AA;  113659 MW;  8827203FFF2D4E59 CRC64;
     MDLNGETSTK RKRSSVAAPA ERPAKHLKPE SSTLTPGDAT PANGTVYDVE DEEDTGRVMP
     IGPAQADSPE WQATIEKVVK SVVSIHFCQT CSFDTDLSMS SQATGFVVDA ERGYILTNRH
     VVCAGPFWGY CIFDNHEECD VRPVYRDPVH DFGILKFDPK AIRYMELTEL KLRPEAARVG
     CEIRVVGNDA GEKLSILSGV ISRLDRNAPE YGDGYCDFNT NYIQAAAAAS GGSSGSPVVN
     IDGHAIALQA GGRADGAATD YFLPLDRPLR ALECIRRGEP VARGTIQTQW ILKPFDECRR
     LGLTPEWEAA VRKASPHETS MLVAEIILPE GPADGKLEEG DVLLQVNGEL LTQFIRLDDI
     LDSSVGKTVR LLVQRGGQNV EVECEVGDLH AITPDRFVTV AGGTFHNLSY QQARLYAIAA
     RGVYVCEAAG SFKLENTLSG WIIDAVDKRP TRNLDEFTEV MKTIPDRARV VISYRHIRDL
     HTRGTSIVYI DRHWHPKMRM AIRNDETGLW DFSDLADPVP AETPVPRKAD FIQLDGVSQP
     AVADIVRSFV RVSCTMPLKL DGYPQAKKTG FGLVIDAEKG LVVVSRAIVP YNLCDINITV
     ADSIIVAAKV IFLHPLQNYT IIQYDPSLVQ APVQSAKLST EYIKQGQETI FVGFNQNFRI
     VVAKTAVTDI TTVSIPANAS APRYRAINLD AITVDTGLSG QCTNGVLIGE DGVVQALWLN
     YLGERTPSSH KDVEYHLGFA TPALLPVTSK IQQGIIPKLR ILNMESYVVQ MSQARIMGVS
     EEWIQKVAQA NPSRHQLFMV RKVDCPPPQF TDNADSLQEG DIILTLDGQL ITRVSELDKM
     YEKEVLDALI VRNGQEMHLK LPTVPTEDLE TDRAVVFCGA VLQKPHHAVR QQISKLHSEV
     YVSARSRGSP AYQYGLAPTN FITAVNGVPT PNLDSFVREV SKIPDNTYFR LRAVTFDNVP
     WVVTMKKNDH YFPMSEYVKD PSQPLGWRTV SHDRDRHKDG ITPDAANLNP DAMDEVYEEV
     SDVEPEVD