NM111_NEUCR
ID NM111_NEUCR Reviewed; 1026 AA.
AC Q7S9D2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Pro-apoptotic serine protease nma111;
DE EC=3.4.21.-;
GN Name=nma111; ORFNames=NCU05200;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAA32963.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CM002239; EAA32963.2; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_962199.2; XM_957106.3.
DR AlphaFoldDB; Q7S9D2; -.
DR SMR; Q7S9D2; -.
DR STRING; 5141.EFNCRP00000004971; -.
DR EnsemblFungi; EAA32963; EAA32963; NCU05200.
DR GeneID; 3878338; -.
DR KEGG; ncr:NCU05200; -.
DR HOGENOM; CLU_003212_0_0_1; -.
DR InParanoid; Q7S9D2; -.
DR OMA; CVFDNHE; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:EnsemblFungi.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0044255; P:cellular lipid metabolic process; IEA:EnsemblFungi.
DR GO; GO:0034605; P:cellular response to heat; IEA:EnsemblFungi.
DR GO; GO:0051438; P:regulation of ubiquitin-protein transferase activity; IEA:EnsemblFungi.
DR GO; GO:0120174; P:stress-induced homeostatically regulated protein degradation pathway; IEA:EnsemblFungi.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR Pfam; PF12812; PDZ_1; 2.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; SSF50156; 3.
DR SUPFAM; SSF50494; SSF50494; 2.
PE 3: Inferred from homology;
KW Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW Serine protease.
FT CHAIN 1..1026
FT /note="Pro-apoptotic serine protease nma111"
FT /id="PRO_0000320357"
FT DOMAIN 305..377
FT /note="PDZ 1"
FT DOMAIN 883..955
FT /note="PDZ 2"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..272
FT /note="Serine protease"
FT COMPBIAS 14..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 120
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 151
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
FT ACT_SITE 233
FT /note="Charge relay system"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1026 AA; 113311 MW; B44B2E795EDDEA2C CRC64;
MNGTSPVARS KRKEPPQYSS DGRLAKHHRT NGDIDMSSAD ANTPTEDFDG HYEEEPRHVL
PLAPGADTAE WQATIENVVR NVVSIRFCQT CSFDTDPALT SEATGFVVDA ERGYILTNRH
VVGSGPFWGY CIFDNHEEVD AYPVYRDPVH DFGILKFDPK AIKYMPVAAL PLRPDLARVG
IEIRVVGNDA GEKLSILSGV ISRLDRNAPE YGDGYSDFNT CYYQASAAAS GGSSGSPVVN
KDGFAVALQA GGRADGASTD YFLPLDRPLR ALKCLQEGKP ITRGDIQCQF VLKPFDECRR
LGLTPEWEAQ VRKAFPKETN MLVAEIILPE GPSHKKLEEG DVLIKVNGKL LTQFIPLEET
LDSSVGQTVK LMLLRGGEEV EVEIEVGDLH QITPDRFVSV SGGSFHNLSY QQARLYGVAC
KGVYVCEAGG SFRFDNNENG WIIQSIDQKE TPDLDTFIEV MKGIPDKARV VITYKHLRDM
HTLHTTVIYV DRHWAKKMKL AVRNDKTGLW DFSNLSDALP AVAPVPRKAS FIQLENTSHP
AVADLVKSFV HVSVTMPVKL DGFPKNRKWG MGLVIDAEKG LVIISRAIVP YDLCDITITI
ADSIVVEGKV VFLHPLQNYA VIQYDPKLVD APVRSAKLSS EMISQGASTY FIGYNRIGRI
VHTATTVTEM FAVTIPANSG APRYRAVNVD AITVDTNLSG QCGSGVLVAQ DGTVQALWLT
YLGERNPSSH RDEEYHLGLA TPTLLPVISQ LQQGITPKLR LLSCEFRAIQ MSQARIMGVS
EEWIQKVSLV NTAHHQLFLV TKRTYERNEP AGDHLKEGDI LLTLNNQLIT KISELDVMYS
HDYLDAVIVR NTKELHIKLP TVAADDAETD HAISFCGAIL HRPHLAVRQQ ISKLFSEVYV
SARTRGSPAY QYGLAPTNFV THVNGKRTPD LKSFLDAVVG IPDNTYFRLK CMTFDSVPWV
VTMKKNEHYF PTTELIKDPS EPLTGWRRIT YEGGKKIEGE GHEGVGVAVL GEDQGEGGEG
DVDGCC
