ID   NM111_PICGU             Reviewed;         991 AA.
AC   A5DAL3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Pro-apoptotic serine protease NMA111;
DE            EC=3.4.21.-;
GN   Name=NMA111; ORFNames=PGUG_00318;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK36220.2; -; Genomic_DNA.
DR   RefSeq; XP_001486941.1; XM_001486891.1.
DR   AlphaFoldDB; A5DAL3; -.
DR   SMR; A5DAL3; -.
DR   STRING; 4929.XP_001486941.1; -.
DR   PRIDE; A5DAL3; -.
DR   EnsemblFungi; EDK36220; EDK36220; PGUG_00318.
DR   GeneID; 5128985; -.
DR   KEGG; pgu:PGUG_00318; -.
DR   VEuPathDB; FungiDB:PGUG_00318; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   InParanoid; A5DAL3; -.
DR   OMA; CVFDNHE; -.
DR   OrthoDB; 93889at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF17820; PDZ_6; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 3.
DR   SUPFAM; SSF50494; SSF50494; 2.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Hydrolase; Nucleus; Protease; Reference proteome; Repeat;
KW   Serine protease.
FT   CHAIN           1..991
FT                   /note="Pro-apoptotic serine protease NMA111"
FT                   /id="PRO_0000320359"
FT   DOMAIN          296..374
FT                   /note="PDZ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          885..957
FT                   /note="PDZ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..269
FT                   /note="Serine protease"
FT   ACT_SITE        117
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        148
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        231
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   991 AA;  110484 MW;  FC071426E7BE021F CRC64;
     MTVGKRKLSN GTVNEAKRLD DHVPVVAPST NPDFENANGE DNEDIDDYSS EGEMSPQLEN
     YFPQTTSWQK TITKVVKSVV SIQFSHVSNF DTESSAVSEA TGFVVDSERG YILTNRHVVG
     PGPFCGYVVF DNHEEAVVRP IYRDPIHDFG FLQFDPKDIR YMKIEQLDLR PDLAQVGTEI
     RVVGNDAGEK LSILAGFISR LDRNAPDYGT LSYNDFNTEY IQAAASASGG SSGSPVVNKE
     GYAVALQAGG STEASTDFFL PVYRPLRALQ CIQQGQTITR GDIQVEWQLK PFDECRRLGL
     TPEAEAAARS QFPDKIGLLV AELVLPEGPA DGKLKEGDTL ISINGTPIAS FISVDEILDE
     QVGQSLKFVI QRNGHEVSFD IVVGDLHSIT PSRYVDIAGA SFNDLSYQVA RCFCIPVRGV
     FINDGSGSFE LSPFEKNGWL LEYVDDKPTP NLDAFVEVMK SIPDRKKVSI SYRHVSDFHT
     ENITVIYVER HWQSTFRMAV RNDSTGIWDF TDIQDKPLPA EEPVPQNAKY IDIPFDDPEK
     SGCSQLTRSF VQVRTIAPVP VDSYPYRREI GYGVVVDAAN GYVLVSRRFV PHDMCDIFVI
     FAESVELPGK VVFLHPNQNY AIVKYDPKLM LADVKTPKFS DKPLKRGERA FFVGYNYNLR
     VVTDDVKVSS VSSINVPVAS LSPRYRGTNL ECILLDSKLS QECDSGVLAD YDGTLRAFWI
     TYLGETNCDQ TNDRVYRMGL DVTDVMSVIK SLHENKVPAG LRILDAEFAS MTIFQGRLRG
     VPQEWISKFE EVCEDEMKFL AVDRVSAPAL GQVATPLKTG DIVMSVNGSI VKTMRDLGIM
     YNQDSLDFVV IRQKKELHLN VPTIDTSTLN TSHVVFWCGS ILQAPHHGVR QLIEKIPSEI
     YVTKKNSGGP ANQYGIATNS FITHVNDTET KTLESFVSVV KGIPDNTYIK LRLVSFDSIP
     VAISVKTNYH YFPTFELKKV NGEWEETEHK V